A5103132307- Acute Ischemic Stroke Management
- Cerebrovascular and Carotid Artery Diseases
- Cardiovascular Health and Disease Prevention
- Stroke Rehabilitation and Recovery
- Blood Pressure and Hypertension Studies
- Traumatic Brain Injury and Neurovascular Disturbances
- Peripheral Neuropathies and Disorders
- Intracerebral and Subarachnoid Hemorrhage Research
- Advanced Neuroimaging Techniques and Applications
- Heart Rate Variability and Autonomic Control
- Venous Thromboembolism Diagnosis and Management
- Medical Image Segmentation Techniques
- Autoimmune Neurological Disorders and Treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Sleep and Wakefulness Research
- Intracranial Aneurysms: Treatment and Complications
- Multiple Sclerosis Research Studies
- COVID-19 diagnosis using AI
- AI in cancer detection
- Prenatal Screening and Diagnostics
- Medical Imaging and Analysis
- Ophthalmology and Eye Disorders
- Nutritional Studies and Diet
- Hereditary Neurological Disorders
- Assisted Reproductive Technology and Twin Pregnancy
Shenzhen Second People's Hospital
2016-2025
Shenzhen University
2016-2024
Shenzhen University Health Science Center
2020-2024
China Medical University
2020-2021
Fifth Tianjin Central Hospital
2018-2019
Capital Medical University
2016-2019
Tianjin Medical University
2019
Beijing Chao-Yang Hospital
2019
Binzhou Medical University
2018
Creative Commons
2017
<h3>Importance</h3> Stroke is the leading cause of death in China. However, recent data about up-to-date stroke burden China are limited. <h3>Objective</h3> To investigate urban-rural disparity Chinese adult population, including prevalence, incidence, and mortality rate, disparities between urban rural populations. <h3>Design, Setting, Participants</h3> This cross-sectional study was based on a nationally representative survey that included 676 394 participants aged 40 years older. It...
Background:The pig is an economically important food source, amounting to approximately 40% of all meat consumed worldwide. Pigs also serve as model organism because their similarity humans at the anatomical, physiological and genetic level, making them very useful for studying a variety human diseases. A strain particular interest miniature pig, specifically Wuzhishan (WZSP), it has been extensively inbred. Its high level homozygosity offers increased ease selective breeding specific traits...
The association between oxidized low-density lipoprotein (oxLDL) and the long-term prognosis of stroke is unclear. aim this study to investigate whether oxLDL levels contribute subtypes.All patients with ischemic were recruited from SOS-Stroke (Study Oxidative Stress in Patients With Acute Ischemic Stroke) classified into 5 different subtypes, according TOAST criteria (Trial Org 10172 Stroke Treatment). We measured followed up at 1 year after onset. analyzed clinical outcomes death poor...
In the field of medical imaging, rapid rise convolutional neural networks (CNNs) has presented significant opportunities for conserving healthcare resources. However, with wide spread application CNNs, several challenges have emerged, such as enormous data annotation costs, difficulties in ensuring user privacy and security, weak model interpretability, consumption substantial computational The fundamental challenge lies optimizing seamlessly integrating CNN technology to enhance precision...
Abstract Background Pre-hospital delay in China is a serious issue with unclear relevant reasons, seriously impeding the adoption of appropriate measures. Herein, we analyzed onset-to-door time (ODT) Chinese patients acute ischemic stroke (AIS) and its influencing factors. Methods We prospectively recruited 3,459 AIS from nine representative tertiary general hospitals between January June 2022. Patients were divided into ODT ≤ 3 h > groups. Following single-factor analysis, binary...
Guillain-Barré syndrome (GBS) is a group of immune-mediated peripheral neuropathies that causes acute flaccid paralysis. The global incidence GBS was 0.6-4/100 000, and the in China 0.698/100 000. Although diagnosis treatment has made rapid progress, approximately 20% patients with are still unable to walk alone within 6 months after onset GBS, 40% have sequelae, such as weakened strength, limb pain, numbness, seriously affecting their life work. We aimed retrospectively analyze clinical...
Prehospital delay in acute ischaemic stroke (AIS) remains prevalent China. We aimed to assess the status of onset-to-door time (ODT) AIS and analyse its influencing factors. Data were collected from a prospective multicentre hospital-based registry (China National Cerebrovascular Disease Prevention Control Project Management Special Database) patients with involving 21 hospitals across different economic geographical regions China 2022. The Mann-Whitney U test or t-test was used for...
Intravenous thrombolysis (IVT) with recombinant tissue plasminogen activator (rt-PA) is the preferred treatment for acute ischemic stroke (AIS). Nevertheless, only approximately half of patients undergoing IVT experience positive outcomes. The objective study was to examine clinical characteristics AIS and identify predictors unfavorable outcomes at 3 months after IVT. This retrospective cohort comprised 3805 consecutive diagnosed who received Patients categorized as having a poor outcome...
Objective Age, hypertension, dyslipidemia and diabetes are common cardiovascular risk factors (CVRFs) that contribute to the development of atherosclerosis in system including carotid artery disease. However, impact these on increased intima-media thickness (cIMT) degree severity remains be further clarified. This study aims evaluate relationship between CVRFs cIMT high-risk subjects. Methods Four thousand three hundred ninety-four subjects with one or more were retrospectively reviewed this...
Sevoflurane is frequently used volatile anesthetic in cancer surgery.It has been suggested that treatment with sevoflurane could suppress migration and invasion of several human cells vitro.However, the effects on colorectal (CRC) remain largely unclear.In this study, CRC HCT116 SW480 were treated by various concentrations sevoflurane.MTT assay Transwell applied to evaluate cell viability, abilities lines, respectively.Real-time quantitative PCR (RT-qPCR) was examine expression level...
Objective: Previous studies suggested that insomnia was associated with an increased risk of cardiocerebral vascular diseases (CVDs) but not clear in different symptoms. We performed a meta-analysis to investigate the association individual symptoms and CVDs. Methods: In this meta-analysis, we systematically searched published articles by using electronic databases including PubMed, Cochrane Library, MedLine, Google Scholar. Studies were enrolled if they indicated symptoms, prospective,...
Thermal ablation is an exciting new minimally invasive treatment that destroys liver tumors without removing them. It uses image guidance to place a needle through the skin into tumor, which highly dependent on surgeons' experience. With development of digital medicine, augmented reality (AR) has become more intuitive and safer way achieve real-time navigation. However, technology still in its infancy due limited accuracy performance. To address these problems, we syncretized holographic AR...
Abstract Whether elevated beat-to-beat blood pressure variability (BPV) has an influence on vascular elasticity is confounded and poorly understood. This study hypothesized that the increased BPV could have adverse effect elasticity, as estimated by total arterial compliance (TAC), independent of (BP) values. Beat-to-beat BP TAC were measured in 81 hypertensive patients (experimental population) 80 normal adults (control population). was assessed standard deviation (SD), average real (ARV),...
Background Whether minor ischemic stroke (MIS) patients can benefit from intravenous thrombolysis (IVT) remains controversial. The association between the efficacy of IVT and baseline National Institute Health Stroke Scale (NIHSS) score is unclear in MIS, while moderate severe known. This study aimed to explore effect with MIS analyze its different NIHSS scores.
The functional assessment of a hemodynamic significant stenosis base on blood pressure variation has been applied for evaluation the myocardial ischemic event. This shows great potential improving accuracy classification severity carotid stenosis. To explore value grading using gradient (PG)-we had reconstructed patient-specific geometries based MRI images-computational fluid dynamics were performed to analyze PG in their stenotic arteries. Doppler ultrasound image data and corresponding 19...
Enolase-phosphatase 1 (ENOPH1), a newly discovered enzyme of the methionine salvage pathway, is emerging as an important molecule regulating stress responses. In this study, we investigated role ENOPH1 in blood brain barrier (BBB) injury under ischemic conditions. Focal cerebral ischemia induced mRNA and protein expression hemispheric microvessels rats. Exposure cultured microvascular endothelial cells (bEND3 cells) to oxygen-glucose deprivation (OGD) also upregulation, which was accompanied...
Ischemic stroke (IS) is one of most common causes disability in adults worldwide. However, there still a lack effective and reliable diagnostic markers therapeutic targets IS. Furthermore, immune cell dysfunction plays an important role the pathogenesis Hence, in-depth research on immune-related progressive IS urgently needed.
The beat-to-beat blood pressure (BP) monitoring parameters, such as average BP, BP variability (BPV), could have an influence on the vascular elasticity. This study hypothesized that elevated BPV evoke reduction of elasticity independent levels. We measured recordings and total arterial compliance (TAC), which was used to assess elasticity, in 80 young healthy adults during cold pressor test (CPT). CPT included 3 phases: baseline phase, stimulus recovery phase. Six parameters were estimate...
Abstract How to avoid the microenvironment limitations in therapeutic process of pressure ulcers is still challenging. The development a functional gel can kill bacteria and scavenge reactive oxygen species (ROS), which urgently required ulcers. Herein, an situ sprayed developed with silver nanoparticles (AgNPs) polydopamine (PDA) NPs (APG) obviate restrictions treating constructed by spraying sodium alginate solution CaCl 2 solution. AgNPs serve as antibacterial agent formed gel,...
Glioblastoma multiforme (GBM) is the most common type of malignant brain tumor, among which IDH1-wild GBM has a poor prognosis. Recent studies have shown that ferroptosis-related genes (FRGs) are correlated with development and progression cancer. In GBM, role FRGs associated IDH1 status as biological indicators therapeutic targets remains to be clarified. Ten (STEAP3, HSPB1, MAP1LC3A, SOCS1, LOX, CAPG, CP, GDF15, CDKN1A, CD44) in were identified key through screening by survival analysis...
This study aims to elucidate the potential links between GLU/GABA GLN metabolic cycle disruptions and onset of depressive insomnia disorders following a stroke. We particularly focus on understanding if these share common underlying pathogenic mechanism.We examined 63 patients with post-stroke insomnia, 62 depression, 18 healthy individuals. The involved assessing using Acute Insomnia Scale (AIS) depression Hamilton Depression Rating Scale. measured serum concentrations GLN, GLU, GABA...