A5038148195- Peanut Plant Research Studies
- Agronomic Practices and Intercropping Systems
- Plant Stress Responses and Tolerance
- Reproductive System and Pregnancy
- Coconut Research and Applications
- Photosynthetic Processes and Mechanisms
- Legume Nitrogen Fixing Symbiosis
- Neuroblastoma Research and Treatments
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Neonatal Respiratory Health Research
- Soybean genetics and cultivation
- RNA modifications and cancer
- Cardiac Imaging and Diagnostics
- Cancer, Hypoxia, and Metabolism
- RNA and protein synthesis mechanisms
- Lipid metabolism and biosynthesis
- Plant Molecular Biology Research
- Immune Response and Inflammation
- Plant Parasitism and Resistance
- Epigenetics and DNA Methylation
- Autophagy in Disease and Therapy
- Nitrogen and Sulfur Effects on Brassica
- Pediatric health and respiratory diseases
- Cancer-related molecular mechanisms research
- Asthma and respiratory diseases
Shandong Academy of Agricultural Sciences
2015-2025
Xuzhou Medical College
2023-2025
Sir Run Run Shaw Hospital
2025
Zhejiang University
2012-2025
Shanxi Agricultural University
2006-2025
Kunming Medical University
2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2009-2024
Ministry of Agriculture and Rural Affairs
2019-2024
Harvard University
2012-2024
Peking Union Medical College Hospital
2005-2024
During several months of 2003, a newly identified illness termed severe acute respiratory syndrome (SARS) spread rapidly through the world1,2,3. A new coronavirus (SARS-CoV) was as SARS pathogen4,5,6,7, which triggered pneumonia and acute, often lethal, lung failure8. Moreover, among infected individuals influenza such Spanish flu9,10 emergence disease viruses11,12 have caused high lethality resulting from failure13. In cell lines, angiotensin-converting enzyme 2 (ACE2) has been potential...
Tracking longitudinal measurements of growth and decline in lung function patients with persistent childhood asthma may reveal links between subsequent chronic airflow obstruction.
A novel coronavirus (COVID-19) has raised world concern since it emerged in Wuhan, China December 2019. The infection may result severe pneumonia with clusters of illness onsets. Its impacts on public health make paramount to clarify the clinical features other pneumonias.Nineteen COVID-19 and 15 patients (non-COVID-19) areas outside Hubei were involved this study. Both non-COVID-19 confirmed be infected using throat swabs and/or sputa with/without COVID-2019 by real-time RT-PCR. We analyzed...
Recent advances in genetics have spurred rapid progress towards the systematic identification of genes involved complex diseases. Still, detailed understanding molecular and physiological mechanisms through which these affect disease phenotypes remains a major challenge. Here, we identify asthma module, i.e. local neighborhood interactome whose perturbation is associated with asthma, validate it for functional pathophysiological relevance, using both computational experimental approaches. We...
Nanotechnology is an important and emerging industry with a projected annual market of around one trillion US dollars by 2011–2015. Concerns about the toxicity nanomaterials in humans, however, have recently been raised. Although studies nanoparticle focused on lung disease molecular link between exposure injury remained unclear. In this report, we show that cationic Starburst polyamidoamine dendrimer (PAMAM), class are being widely developed for clinical applications can induce acute vivo....
Metal oxide nanoparticles (NPs) are among the most highly produced nanomaterials, and have many diverse functions in catalysis, environmental remediation, as sensors, production of personal care products. In this study, toxicity several widely used metal NPs such copper oxide, silica, titanium ferric NPs, were evaluated vitro. We exposed A549, H1650 CNE-2Z cell lines to found CuO be toxic, SiO2 mild while other had little effect on viability. Furthermore, autophagic biomarker LC3-II...
Blocking autophagy reduces the extent of lung damage and decreases mortality in mice infected with H5N1 strain avian influenza.
A genetic locus within the FAM13A gene has been consistently associated with chronic obstructive pulmonary disease (COPD) in genome-wide association studies. However, mechanisms by which contributes to COPD susceptibility are unknown.To determine biologic function of human and murine models discover molecular mechanism influences susceptibility.Fam13a null mice (Fam13a(-/-)) were generated exposed cigarette smoke. The lung inflammatory response airspace size assessed Fam13a(-/-) Fam13a(+/+)...
How cancer cells shift metabolism to aerobic glycolysis is largely unknown. Here, we show that deficiency of α/β-hydrolase domain-containing 5 (Abhd5), an intracellular lipolytic activator also known as comparative gene identification 58 (CGI-58), promotes this metabolic and enhances malignancies colorectal carcinomas (CRCs). Silencing Abhd5 in normal fibroblasts induces malignant transformation. Intestine-specific knockout Apc(Min/+) mice robustly increases tumorigenesis transformation...
Belowground interactions mediated by root exudates are critical for the productivity and efficiency of intercropping systems. Herein, we investigated process microbial community assembly in maize, peanuts, shared rhizosphere soil as well their regulatory mechanisms on under different planting patterns combining metabolomic metagenomic analyses. The results showed that yield intercropped maize increased significantly 21.05% (2020) 52.81% (2021), while peanut decreased 39.51% 32.58% (2021)....
The MYC oncogenic transcription factor is overexpressed in most human cases of T cell acute lymphoblastic leukemia (T-ALL), often downstream mutational NOTCH1 activation. Genetic alterations the PTEN–PI3K–AKT pathway are also common T-ALL. We generated a conditional zebrafish model T-ALL which 4-hydroxytamoxifen (4HT) treatment induces activation and disease, withdrawal 4HT results apoptosis tumor regression. However, we found that loss-of-function mutations pten genes, or expression...
Overnutrition activates a proinflammatory program in macrophages to induce insulin resistance (IR), but its molecular mechanisms remain incompletely understood. Here, we show that saturated fatty acid and lipopolysaccharide, two factors implicated high-fat diet (HFD)-induced IR, suppress macrophage CGI-58 expression. Macrophage-specific knockout (MaKO) mice aggravates HFD-induced glucose intolerance which is associated with augmented systemic/tissue inflammation activation of adipose tissue...
Summary Neurofibromatosis type 1 (NF1) is a common, dominantly inherited genetic disorder that results from mutations in the neurofibromin gene. Affected individuals demonstrate abnormalities neural crest-derived tissues include hyperpigmented skin lesions and benign peripheral nerve sheath tumors. NF1 patients also have predisposition to malignancies including juvenile myelomonocytic leukemia (JMML), optic glioma, glioblastoma, schwannoma, malignant tumors (MPNSTs). In an effort better...
Triglyceride (TG) accumulation in hepatocytes (hepatic steatosis) preludes the development of advanced nonalcoholic fatty liver diseases (NAFLDs) such as steatohepatitis, fibrosis, and cirrhosis. Mutations human Comparative Gene Identification-58 (CGI-58) cause cytosolic TG-rich lipid droplets to accumulate almost all cell types including hepatocytes. However, it is unclear if CGI-58 mutation causes hepatic steatosis locally or via altering metabolism other tissues. To directly address this...
Significance Genome-wide association studies (GWAS) have been very successful in discovering genetic loci associated with complex traits. However, only few applied murine models to investigate how GWAS genes contribute human lung diseases. Motivated by linking Hedgehog interacting protein ( HHIP ) emphysema and impairments function, this study demonstrated that Hhip +/− mice developed spontaneous function impairment over time. Moreover, emphysema, increased oxidative stress lungs, was...
Recurrent, rapidly growing nasal polyps are hallmarks of aspirin-exacerbated respiratory disease (AERD), although the mechanisms polyp growth have not been identified. Fibroblasts intimately involved in tissue remodeling, and fibroblasts is suppressed by prostaglandin E2 (PGE2), which elicits antiproliferative effects mediated through E prostanoid (EP)2 receptor. We now report that cultured from subjects with AERD resist this effect. resisted actions PGE2 a selective EP2 agonist (P < 0.0001...