A5005095734- Sugarcane Cultivation and Processing
- Natural Products and Biological Research
- Digital Marketing and Social Media
- Consumer Behavior in Brand Consumption and Identification
- Genetics and Neurodevelopmental Disorders
- Mental Health Research Topics
- Bipolar Disorder and Treatment
- Impact of Technology on Adolescents
- Biofuel production and bioconversion
- Genetic Associations and Epidemiology
- Schizophrenia research and treatment
- Health, Environment, Cognitive Aging
- Sleep and related disorders
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Media, Gender, and Advertising
- Plant Gene Expression Analysis
- Bioinformatics and Genomic Networks
- Technology Adoption and User Behaviour
- Media Influence and Health
- Lymphoma Diagnosis and Treatment
- Psychosomatic Disorders and Their Treatments
- Functional Brain Connectivity Studies
- Cytokine Signaling Pathways and Interactions
- Psoriasis: Treatment and Pathogenesis
- Genomics and Rare Diseases
Guangdong Pharmaceutical University
2025
Wuhan Textile University
2022-2024
Fujian Agriculture and Forestry University
2020-2024
China University of Geosciences
2020-2022
Affiliated Hospital of Southwest Medical University
2017-2021
Sartorius (United States)
2019
First Affiliated Hospital of Sichuan Medical University
2018
Janssen (United States)
2015-2017
Springhouse
2015-2017
Sichuan University
2014-2015
Recent advances in genetics have spurred rapid progress towards the systematic identification of genes involved complex diseases. Still, detailed understanding molecular and physiological mechanisms through which these affect disease phenotypes remains a major challenge. Here, we identify asthma module, i.e. local neighborhood interactome whose perturbation is associated with asthma, validate it for functional pathophysiological relevance, using both computational experimental approaches. We...
Abstract Background APETALA2/ETHYLENE RESPONSIVE FACTOR (AP2/ERF) transcription factors play essential roles in plant growth, development, metabolism, and responses to biotic abiotic stresses. However, few studies concerning AP2/ERF genes sugarcane which are the most critical sugar energy crops worldwide. Results A total of 218 were identified Saccharum spontaneum genome. Phylogenetic analysis showed that these could be divided into four groups, including 43 AP2s, 160 ERFs...
Although genome-wide association studies (GWAS) have identified over 100 genetic loci associated with rheumatoid arthritis (RA), our ability to translate these results into disease understanding and novel therapeutics is limited. Most RA GWAS reside outside of protein-coding regions likely affect distal transcriptional enhancers. Furthermore, do not identify the cell types where causal gene functions. Thus, mapping regulatory roles hits relevant will lead better pathogenesis. We combine...
Drought is the main abiotic stress that constrains sugarcane growth and production. To understand molecular mechanisms govern drought stress, we performed a comprehensive comparative analysis of physiological changes transcriptome dynamics related to highly drought-resistant (ROC22, cultivated genotype) weakly (Badila, wild sugarcane, in time-course experiment (0 h, 4 8 16 h 32 h). Physiological examination reviewed ROC22, which shows superior tolerance relative Badila, has high performance...
Several small studies suggest that the presence of human leukocyte antigen (HLA)-Cw6 (C*06:02) allele may be a predictor improved response to ustekinumab. This study was designed assess association HLA-C*06:02 with ustekinumab in large cohorts patients from phase 3 moderate-to-severe psoriasis. In this retrospective study, both HLA-C*06:02-positive and -negative demonstrated good responses (86% vs. 76%, respectively, achieved at least 75% improvement baseline Psoriasis Area Severity Index...
Indigo naturalis is a Traditional Chinese Medicine (TCM) ingredient long-recognized as therapy for several inflammatory conditions, including psoriasis. However, its mechanism unknown due to lack of knowledge about the responsible chemical entity. We took different approach this challenge by investigating molecular profile treatment and impacted pathways. A randomized, double-blind, placebo-controlled clinical study was conducted using topical monotherapy treat moderate plaque psoriasis in...
Abstract Background Internet gaming disorder (IGD) is a type of behavioural addictions. One the key features addiction excessive exposure to addictive objectives (e.g. drugs) reduces sensitivity brain reward system daily rewards money). This thought be mediated via signals expressed as dopaminergic prediction error (RPE). Emerging evidence highlights blunted RPE in drug However, no study has examined whether IGD also involves alterations that are observed other types Methods To fill this...
A genetic diversity analysis and identification of plant germplasms varieties are important necessary for breeding. Deoxyribonucleotide (DNA) fingerprints based on genomic molecular markers play an role in accurate germplasm identification. In this study, Specific-Locus Amplified Fragment Sequencing (SLAF-seq) was conducted a sugarcane population with 103 cultivated wild accessions. total, 105,325 single nucleotide polymorphisms (SNPs) were called successfully to analyze components...
Previous studies have inferred a strong genetic component for insomnia. However, the etiology of insomnia is still unclear. The aim current study was to explore potential biological pathways, gene networks, and brain regions associated with insomnia.Using pathways (gene sets) from Reactome, we carried out two-stage set enrichment analysis strategy. From large genome-wide association (GWASs) symptoms (32,155 cases/26,973 controls), significant sets were tested replication in other GWASs...
Public health emergencies can trigger individual death anxiety. Most previous studies focus on the negative effects of anxiety via Western materialistic view, neglecting both positive aspects within Chinese cultural background and upon environmental consumption. By implementing unique for concepts justice interests, this study explores influence altruistic consumption during COVID-19 crisis by analyzing personal life reviews other sources. The results show that (1) under guidance correct...
Next-generation sequencing (NGS) technologies have become much more efficient, allowing whole human genomes to be sequenced faster and cheaper than ever before. However, processing the raw sequence reads associated with NGS requires care sophistication in order draw compelling inferences about phenotypic consequences of variation genomes. It has been shown that different approaches variant calling from data can lead conclusions. Ensuring appropriate accuracy quality come at a computational...
As consumers become skeptical of green products, brands may need to put trust-building on their business agenda. The study aims use the rhetorical theory Aristotle examine influence a brand story perceived sincerity and trust. explores whether customer value (CPV) mediates effect between three means persuasion used by sincerity, for cognition (NFC) plays moderating role. A model is proposed tested through independent experiments in which participants were exposed stories asked complete...
Background Genome‐wide association studies ( GWASs ) are used to identify genetic variants for with bipolar disorder BD risk; however, each GWAS can only reveal a small fraction of this association. This study systematically analyzed multiple data sets provide further insights into potential causal processes by integrating the results Psychiatric Genomics Consortium Phase I PGC ‐I) core human pathways and functional networks. Methods The i‐Gsea4GwasV2 program was analyze from ‐I (the came...
Abstract Online customer reviews play a vital role in evaluating product or service performance and serve as an important reference for other customers' purchase decisions. This study explores the influence of online on sustainable clothing intention through text mining survey‐based methodologies. The results showed that focused four dimensions: material ecology, fashion, functionality, price reasonableness. have positive impact consumers' intentions, perceived diagnosticity mediates...
Digital human narrative transportation has proven to be an effective green brand marketing strategy. However, there is still a lack of in-depth research on the relationship between role different digital scenarios in consumer perceptions and behaviors. This examined impact eco-product purchase intention through four studies. Study 1 found that anime-like (vs. human-like) narratives led more positive emotional arousal higher use encephalography (EEG) experiments. Studies 2–4 effect intentions...
An individual patient's response to a particular drug is influenced by multiple factors, which may include genetic predisposition. Pharmacogenetic studies attempt discover and estimate the contributions of variants variability in treatment. The task identifying contribution often complicated phenotypes that are based on imprecise or subjective clinical observations. Because success pharmacogenetic study depends analysis heritable phenotype, it important identify with significant component...
The death/suicide implicit association test (IAT) may be more resilient to accurately assess suicide risk than self-reports. We examined the IAT in 130 patients with depression and 125 healthy controls, along self-reported suicidal ideation. could differentiate attempts from without controls. measures were significantly correlated explicit ideation clinical symptoms patients. Moreover, IAT-symptom correlations significant female but not male showed promise as a valid tool estimate particularly useful
Working memory deficit is the core neurocognitive disorder in schizophrenia patients. To identify factors underlying working patients and to explore implication of possible genes using genome-wide association study (GWAS) schizophrenia, computerized delay-matching-to-sample (DMS) whole genome genotyping data were obtained from 100 first-episode, treatment-naïve with 140 healthy controls Mental Health Centre West China Hospital, Sichuan University. A composite score, total correct numbers...
Both elevated intolerance of uncertainty (IU) and maladaptive metacognitive beliefs (MBs) were associated with depression. However, the relationship between MBs IU in clinical depression is unclear. The current study aimed to investigate putative impairment major depressive disorder (MDD) explore these two factors symptoms. Metacognition Questionnaire-30 Items (MCQ-30), Intolerance Uncertainty Scale-Short Form (IUS-12) rating scales administered 53 patients MDD 56 healthy controls (HCs)....
Virtual reality (VR) technology has become increasingly prevalent in marketing and consumer education [1][2].Customer is effective enhancing brand awareness changing intentions.However, most current forms of green educational activities are mainly popular as science education.The creation scenes relatively single.The breadth depth content insufficient, the immersion interaction effects traditional for consumers insufficient.VR significant advantages with regard to physical scenarios...