A5100458769- Nutrition and Health in Aging
- Adipose Tissue and Metabolism
- Body Composition Measurement Techniques
- Diet and metabolism studies
- Asthma and respiratory diseases
- Frailty in Older Adults
- Pediatric health and respiratory diseases
- Hip and Femur Fractures
- Gut microbiota and health
- Nitric Oxide and Endothelin Effects
- Muscle metabolism and nutrition
- Adipokines, Inflammation, and Metabolic Diseases
- Thyroid Cancer Diagnosis and Treatment
- Genital Health and Disease
- Fibroblast Growth Factor Research
- Anorectal Disease Treatments and Outcomes
- Cardiovascular Health and Risk Factors
- Head and Neck Anomalies
- Nutritional Studies and Diet
- Body Contouring and Surgery
- Periodontal Regeneration and Treatments
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Child Nutrition and Water Access
- Muscle Physiology and Disorders
- Hernia repair and management
Wuhan University
2025
Renmin Hospital of Wuhan University
2025
Chengdu Medical College
2025
Chengdu University
2023-2025
Hebei University of Science and Technology
2024
First Affiliated Hospital of Chengdu Medical College
2023
Zhongshan Hospital
2023
Fudan University
2023
Peking Union Medical College Hospital
2023
Chinese Academy of Medical Sciences & Peking Union Medical College
2023
Recent advances in genetics have spurred rapid progress towards the systematic identification of genes involved complex diseases. Still, detailed understanding molecular and physiological mechanisms through which these affect disease phenotypes remains a major challenge. Here, we identify asthma module, i.e. local neighborhood interactome whose perturbation is associated with asthma, validate it for functional pathophysiological relevance, using both computational experimental approaches. We...
Benralizumab, a humanized, afucosylated, monoclonal antibody that targets interleukin-5 receptor α, depletes eosinophils and basophils by enhanced antibody-dependent cell-mediated cytotoxicity. It demonstrated efficacy for patients with moderate to severe asthma and, in Phase IIa trial, chronic obstructive pulmonary disease (COPD) eosinophilic inflammation. We investigated effects of benralizumab 100 mg every 8 weeks (first three doses 4 weeks) subcutaneous on blood inflammatory markers...
Background: Telomere shortening and dysfunction may cause metabolic disorders, tissue damage age-dependent pathologies. However, little is known about the association of telomere-associated protein Rap1 with mitochondrial energy metabolism cardiac aging. Methods: Echocardiography was performed to detect structure function in Rap1+/+ Rap1-/- mice at different ages (3 months, 12 months 20 months). length, DNA damage, senescence cardiomyocyte size were analyzed using real-time PCR, Western...
As the world experiences a demographic shift towards aging populations, there will be significant surge in number of sarcopenia patients, along with an unprecedented expansion associated economic burden. The multitudinous risk factors for have been reported, but evidence air pollution remains rare.This cross-sectional study employed multi-stage random sampling to select 1592 participants over 40 years age from Hubei Province. Daily mean concentrations pollutants were collected...
Background: Although the importance of gender as a key determinant in health and illness has been recognized for long time, systematic studies differences medicine are still lacking. We hypothesized that interscapular brown adipocyte tissue (BAT), is not only contributing to energy expenditure, but also regulates diet-induced thermogenesis, may be an ideal target studying obesity development response high fat diet (HFD). Methods: therefore performed differential proteome analysis BAT from...
Fall is a major cause of mortality and significant burden on the healthcare system economic system. Weak grip strength signifies impaired function. Older people with weak are at higher risk death. China has largest ageing population in world today. This study aims to analyze factors contributing fall among Chinese.This analyzed data from 2011 baseline 2015 follow-up survey Health Retirement Longitudinal Study (CHARLS). To identify strength, we used stepwise multivariable logistic regression...
Abstract Background and Hypothesis The multifactorial pathogenesis of schizophrenia (SZ) hinders the diagnosis treatment this disorder. Niacin skin flushing response (NSFR) has been identified as an endophenotype for SZ, but proportion blunted NSFR (BNR) varied between studies. This study aims to clarify relationship SZ through a meta-analysis. Study Design PubMed, Embase, Web Science, Cochrane, Scopus databases were searched articles published until May 2024, 32 studies eligible. Using...
Asymmetric dimethylarginine (ADMA) is an endogenous inhibitor of nitric oxide (NO) synthase (NOS), and endothelial dysfunction related to the elevation ADMA level in hypertension. Besides NO-mediated pathway, endothelium-derived hyperpolarizing factor (EDHF)-mediated pathway involved dysfunction. The aims present study were evaluate changes endothelium-dependent dilatation arteries hypertension role NO- EDHF-mediated vasodilatation. great omental isolated from essential hypertensive...
Abstract Background Cancer cachexia is prevalent in digestive tract cancer patients and has significant impacts on prognosis; it vital to identify individuals who are at risk of allow for appropriate evaluation treatment. This study evaluated whether with a had adverse survival could be identified before abdominal surgery. Methods large‐scale cohort involved underwent surgery between January 2015 December 2020 treat cancer. Participants were allocated the development cohort, validation or...
This study aimed to develop a simplified diagnostic tool for assessing sarcopenia and myosteatosis in gastrointestinal cancer patients, focusing on the creatinine cystatin C ratio (CCR) as an evaluation marker.955 patients were split into training (n = 671) validation 284) cohorts. Using logistic regression, risk factors identified. The predictive capacity of developed model was examined. association between CCR muscle imaging parameters, along with its impact clinical outcomes, analyzed.No...
Background: Proper understanding of molecular mechanisms underlying gender dimorphism in obesity for better nutritional recommendation is still early stages. As white adipose tissues (WAT) most important tissue metabolism, comparative proteomic analysis all three WAT deposits at the same time to yield immensely protein markers was primary goal this study. Methods: We performed differential expression profiles different viz. subcutaneous, inguinal, and abdominal fat both genders lean obese...
Background: Although it has been believed for a long time that gender differences in physiology and metabolism were not relevant beyond the reproductive system, new research indicated sexual dimorphism may be more prevalent than previously believed. Therefore, goal of this study was to develop global view changes gender-dependent protein abundance two different types skeletal muscles (soleus gastrocnemius) lean high fat diet (HFD)-induced obese rats. Methods: To examine differential...
Background: The ultimate goal of intestinal failure (IF) management is to maintain optimal nutritional status, improve the quality life (QoL), and promote adaptation. Enteral nutrition support safe effective in patients with IF plays a central role IF. purpose this study was evaluate effect home enteral on body composition (BC), QoL other clinical outcomes malnourished failure. Methods: This prospective observational included 166 presented Jinling Hospital from January 2016 October 2018. All...