A5100651062- Cancer Immunotherapy and Biomarkers
- Lung Cancer Research Studies
- Lung Cancer Treatments and Mutations
- Radiomics and Machine Learning in Medical Imaging
- Lung Cancer Diagnosis and Treatment
- Influenza Virus Research Studies
- Gastric Cancer Management and Outcomes
- Venous Thromboembolism Diagnosis and Management
- Brain Metastases and Treatment
- Colorectal Cancer Treatments and Studies
- Respiratory viral infections research
- Ferroptosis and cancer prognosis
- Pancreatic and Hepatic Oncology Research
- Respiratory Support and Mechanisms
- Cancer Cells and Metastasis
- Animal Disease Management and Epidemiology
- Glioma Diagnosis and Treatment
- Connexins and lens biology
- Epigenetics and DNA Methylation
- Immune Response and Inflammation
- Gastrointestinal motility and disorders
- Cancer Genomics and Diagnostics
- T-cell and B-cell Immunology
- Neonatal Respiratory Health Research
- Neuroendocrine Tumor Research Advances
Shandong First Medical University
2014-2025
Sichuan University
2021-2025
State Key Laboratory of Oral Diseases
2025
Shandong Provincial QianFoShan Hospital
2025
Shandong Provincial Hospital
2023-2025
ShanghaiTech University
2024
Tianjin University of Science and Technology
2024
West China Hospital of Sichuan University
2021-2024
Weatherford College
2024
Chinese PLA General Hospital
2014-2023
A novel coronavirus (COVID-19) has raised world concern since it emerged in Wuhan, China December 2019. The infection may result severe pneumonia with clusters of illness onsets. Its impacts on public health make paramount to clarify the clinical features other pneumonias.Nineteen COVID-19 and 15 patients (non-COVID-19) areas outside Hubei were involved this study. Both non-COVID-19 confirmed be infected using throat swabs and/or sputa with/without COVID-2019 by real-time RT-PCR. We analyzed...
Abstract Background Lung cancer is the most commonly diagnosed worldwide. Its survival rate can be significantly improved by early screening. Biomarkers based on radiomics features have been found to provide important physiological information tumors and considered as having potential used in screening of lung cancer. In this study, we aim establish a model develop tool improve discrimination between benign malignant pulmonary nodules. Methods A retrospective study was conducted 875 patients...
The efficacy of current treatment regimens for pancreatic cancer (PC) remains unsatisfactory. In recent years, immune checkpoint blockade (ICB) therapy has shown promising anti-tumor outcomes in many malignancies, including PC. Inexpensive and readily available biomarkers which predict therapeutic responses prognosis are critical need. Systemic immune-inflammation index (SII) neutrophil-lymphocyte ratio (NLR) emerging predictors various tumors. We aim to investigate the prognostic...
Engineered T cells represent an emerging therapeutic modality. However, complex engineering strategies can present a challenge for enriching and expanding at clinical scale. In addition, lack of in vivo cytokine support lead to poor engraftment transferred cells, including regulatory (T
Comparative genomic analyses of Leishmania species have revealed relatively minor heterogeneity amongst recognised housekeeping genes and yet the cause distinct infections pathogenesis in their mammalian hosts. To gain greater information on biochemical variation between species, insights into possible metabolic mechanisms underpinning visceral cutaneous leishmaniasis, we undertaken this study a comparative analysis metabolomes promastigotes L. donovani, major mexicana. The 64 metabolites...
Background: Serum tumor markers carcinoembryonic antigen (CEA), cancer 125 (CA125), cytokeratin 19 fragment (CYFRA21-1) and squamous-cell carcinoma-related (SCC-Ag) are routinely used for monitoring the response to chemotherapy or targeted therapy in advanced-stage non-small cell lung (NSCLC), however their role immunotherapy remains unclear. The aim of this study was investigate whether dynamics these serum could predict prognosis patients with late-stage NSCLC treated by programmed...
Biomolecular condensates segregate nuclei into discrete regions, facilitating the execution of distinct biological functions. Here, it is identified that WW domain containing adaptor with coiled-coil (WAC) localized to nuclear speckles via its and plays a pivotal role in regulating alternative splicing through formation biomolecular C-terminal (CC) domain. WAC acts as scaffold protein facilitates integration RNA-binding motif 12 (RBM12) speckles, where RBM12 potentially interacts...
Background: Diabetic nephropathy (DN) commonly occurs as a microvascular complication in individuals with diabetes mellitus (DM). The progression of renal dysfunction DN patients leads to marked rise the risk cardiovascular disease (CVD). At present, effective treatment and CVD necessitates identification management their factors. Methods: Patients diagnosed from October 2022 2023 were selected for cross-sectional study divided into group (n = 58) DN/CVD 40). Clinical data collected...
Abstract Introduction Behçet's disease (BD) is a chronic, systemic inflammatory condition characterized by recurrent immune dysregulation. Materials & Methods This study conducted comprehensive analysis of cell subsets, metabolic markers, and their interplay in BD patients. Using multiparametric flow cytometry, we identified elevated Th1 cells, senescent CD8+ T abnormal B activation as hallmarks the chronic state BD. Results Despite immunotherapy, innate persisted, with increased mature...
Targeting immune checkpoints represents an immense breakthrough in cancer therapeutics. The prognostic value of hemoglobin (Hb) has been investigated many malignancies including non-small cell lung (NSCLC). However, the impact pretreatment Hb count for checkpoint inhibitors (ICIs) advanced NSCLC patients remains unclear.A total 310 late-stage who received ICI therapies between January 2015 and March 2019 were prospectively enrolled. We used a propensity score-matched cohort analysis this...
Immune checkpoint inhibitors (ICIs) represent a great breakthrough in the treatment of advanced non-small cell lung cancer (aNSCLC). However, whether immunotherapy beyond progression (IBP) is effective for aNSCLC has yet to be established. Therefore, retrospective clinical study was conducted investigate efficacy IBP patients with under real-world conditions.A total 125 Chinese who experienced progressive disease (PD) after receiving monotherapy or combination therapy (combined chemotherapy...
Advanced non-small cell lung cancer (NSCLC) patients with poor performance status (PS) are likely to receive programmed death 1 (PD-1) inhibitors, despite limited evidence. The aim of the present study was report clinical outcomes and potential prognostic biomarkers in advanced NSCLC PS receiving PD-1 inhibitors.We conducted a retrospective enrolling 101 from our hospital. Data 2-4 inhibitors were retrieved medical records. Patients stratified based on dichotomized baseline...
Hospitalized cancer patients are at high risk of venous thromboembolism (VTE). However, no predictive model has been specifically developed for this population. Machine learning (ML) is advantageous development. This study was aimed developing models using three different ML algorithms and logistic regression VTE among hospitalized comparing their performance.A retrospective case-control conducted on Hunan Cancer Hospital, China, between October 1, 2021, February 30, 2022. Patients diagnosed...
Endometriosis is a puzzling and debilitating disease that affects millions of women around the world. Ovary most common organ site involved by endometriosis. Despite various hypotheses about its cell origin, uncertainty remains. On basis our clinicopathologic observations, we hypothesize fallopian tube may contribute histogenesis ovarian To examine if hypothesis, tubal origin endometriosis, has scientific supporting evidence, identified set novel genes, which are either highly expressed in...
The aim of this study was to find the most useful marker endometriosis-related infertility and evaluate predictive diagnostic values systemic inflammatory response markers (preoperative white blood-cell subtypes, neutrophil:lymphocyte ratio [NLR], platelet:lymphocyte [PLR], monocyte:lymphocyte [MLR]) CA125 levels in endometriosis patients.This comprised 662 women who had undergone laparoscopic surgery been pathologically confirmed as having 83 patients with benign ovarian tumors. Related...
Immune checkpoint inhibitors (ICIs) have become standard treatments for lung cancer patients. inhibitor-related pneumonitis (CIP) was the leading cause of death among ICIs-related adverse events (irAEs). Recurrent episodes CIP without rechallenge ICIs were reported in several cases and maybe a unique feature CIP. Knowledge gaps remain regarding rate risk factors associated to CIP's recurrence.Data from 1,102 patients receiving treatment between January 2016 2021 retrospectively collected...
Background: Rechallenge of immunotherapy beyond progression (RIBP) has been demonstrably effective in a variety cancers. Our study aims to investigate the efficacy RIBP small-cell lung cancer (SCLC) patients under real-world conditions. Methods: SCLC who experienced progressive disease after receiving programmed cell death-1 (PD-1)/programmed death ligand-1 (PD-L1) inhibitors combined with chemotherapy from January 2017 October 2021 were enrolled. The population was divided into two groups:...
Importance Despite the recommendations of lung cancer screening guidelines and evidence supporting effectiveness population-based screening, a common barrier to effective is that participation rates low-dose computed tomography (LDCT) among individuals with highest risk are not large. There limited data from clinical practice regarding whether opportunistic LDCT associated reduced lung-cancer mortality. Objective To evaluate improved prognosis adults in mainland China. Design, Setting,...