A5100320379- Synthesis and biological activity
- Click Chemistry and Applications
- Synthesis and Biological Evaluation
- Cancer therapeutics and mechanisms
- Microtubule and mitosis dynamics
- Synthesis of Organic Compounds
- Cancer-related Molecular Pathways
- Carbohydrate Chemistry and Synthesis
- Quinazolinone synthesis and applications
- Bioactive natural compounds
- Synthesis and Characterization of Heterocyclic Compounds
- Cancer Mechanisms and Therapy
- Multicomponent Synthesis of Heterocycles
- Bioactive Compounds and Antitumor Agents
- Drug Transport and Resistance Mechanisms
- Biological and pharmacological studies of plants
- Ubiquitin and proteasome pathways
- Metal complexes synthesis and properties
- Gout, Hyperuricemia, Uric Acid
- Microwave-Assisted Synthesis and Applications
- Cell death mechanisms and regulation
- Quantum Information and Cryptography
- Quantum optics and atomic interactions
- Chemical Synthesis and Reactions
- Organoselenium and organotellurium chemistry
Tsinghua University
2007-2025
Shenyang Pharmaceutical University
2015-2024
Guiyang Medical University
2019
Shandong University of Science and Technology
2014
Jinan University
2008-2012
China Medical University
2010-2011
First Hospital of China Medical University
2010-2011
Sichuan Research Center of New Materials
2007
ZLDI-8 is an A disintegrin and metalloproteinase domain 17 (ADAM17) inhibitor that suppresses the shedding of Notch1 to intracellular (NICD). In previous studies, we found was able sensitize HCC sorafenib, but mechanism action remains unclear. The sensitizing effects were tested both in vitro vivo. EMT-related factors, sorafenib sensitivity-related proteins ECM-related gene expression assessed using immunohistochemistry, RTPCR Western blotting. Knockdown assays conducted determine...
The development of suitable chiral ligands and catalysts is a key factor in asymmetric organic synthesis. In this paper, we describe the design, synthesis evaluation new kind adjustable axially cyclic biphenyl derived from biphenyldiols, four representative examples were performed well including enantioselective alkynylation benzo[e][1,2,3]oxathiazine 2,2-dioxide under catalysis (R)-cyclic [1,1'-biphenyl]-2,2'-diol/ZnMe2, palladium-catalyzed decarboxylative cycloaddition...
Quantum entanglement, the essential resource for quantum information processing, has rich dynamics under different environments. Probing entanglement typically requires exquisite control of complicated system-environment coupling in real experimental systems. Here, by a simple effective solid-state spin bath diamond sample, we observe dynamics, including conventional asymptotic decay as well sudden death, term coined phenomenon complete disappearance after short finite time interval....
An efficient selective demethylation and debenzylation method for aryl methyl/benzyl ethers using magnesium iodide under solvent-free conditions has been developed applied to the synthesis of natural flavone biphenyl glycosides. A variety functional groups including glycoside were tolerated reaction conditions. Experimental results indicated that removal an O-benzyl group was easier than O-methyl group, regardless wherever they meta or para carbonyl. Thus can be achieved substrates bearing...
Abstract A series of 3-(3′-hydroxy-4′-methoxyphenyl)selenyl-5,6,7-trimethoxy-1 H -indoles and 3-(3′-hydroxy-4′-methoxyphenyl)thio-5,6,7-trimethoxy-1 were obtained as a new class combretastatin A-4 (CA-4) analogues via convenient ultrasound (US)-assisted two-step process involving 3-selenenylation/sulfenylation followed by O -deallylation. With the assistance US irradiation, both reaction rates yields selenenylation, sulfenylation -deallylation could be significantly improved. comparison...
A series of 3,6-diaryl-[1,2,4]triazolo[4,3-b]pyridazines were designed as a class vinylogous CA-4 analogues. The easily isomerized (Z,E)-butadiene linker was replaced by rigid [1,2,4]triazolo[4,3-b]pyridazine scaffold. Twenty-one target compounds synthesized and exhibited moderate to potent antiproliferative activity. compound 4q with 3-amino-4-methoxyphenyl moiety the B-ring, comparable (IC50 = 0.009–0.012 μM), displayed highly active activity against SGC-7901, A549, HT-1080 cell lines IC50...
A series of N,4-diaryl-1,3-thiazole-2-amines containing three aromatic rings with an amino linker were designed and synthesized as tubulin inhibitors evaluated for their antiproliferative activity in human cancer cell lines. Most the target compounds displayed moderate activity, N-(2,4-dimethoxyphenyl)-4-(4-methoxyphenyl)-1,3-thiazol-2-amine (10s) was determined to be most potent compound. Tubulin polymerization immunostaining experiments revealed that 10s potently inhibited disrupted...
A series of 2-phenyl-5-methyl-2<italic>H</italic>-1,2,3-triazole-4-carboxylic acids/carbohydrazides as analogues febuxostat were synthesized and evaluated for their <italic>in vitro</italic> xanthine oxidase (XO) inhibitory activity.
The first total synthesis of bulbophylol-B (1) has been achieved with the longest linear sequence 12 steps and an overall yield 17.9% via a new practical approach to construct dihydrodibenz[b,f]oxepin skeleton employing Wittig, selective reduction, intramolecular Ullmann reactions as key steps.
Breast cancer is the leading cause of death in women worldwide, and novel chemotherapeutic drugs with high activity no drug resistance for treating breast are needed urgently. In this study, we investigated antitumor effect 2-methoxy-5((3,4,5-trimethosyphenyl)seleninyl) phenol (SQ0814061), which has a strong inhibition cell growth MCF-7 MDA-MB-231 cells. We demonstrated that SQ0814061 (SQ) time-dependently induced cycle arrest at G2/M phase subsequently progressed into apoptosis, associated...
Abstract A series of 5-aryl-4-(4-arylpiperazine-1-carbonyl)-2 H -1,2,3-triazol derivatives were designed as potential microtubule targeting agents. The regioselective alkylation -1,2,3-triazole was predicted by computations and confirmed an unambiguous synthetic route. antiproliferative activity the synthesized compounds tested in vitro using three human cancer cell lines some exhibited significant activity, which suggested reasonability introduction 1,2,3-triazole fragment. Among them,...