A5100652083- Cancer Mechanisms and Therapy
- Neurological Disease Mechanisms and Treatments
- Hepatocellular Carcinoma Treatment and Prognosis
- Pancreatic function and diabetes
- Xenotransplantation and immune response
- Neurological Disorders and Treatments
- Cerebrovascular and Carotid Artery Diseases
- Cholinesterase and Neurodegenerative Diseases
- Nanoplatforms for cancer theranostics
- Cancer therapeutics and mechanisms
- Computational Drug Discovery Methods
- Diabetes and associated disorders
- Synthesis and bioactivity of alkaloids
- Dementia and Cognitive Impairment Research
- Nanoparticle-Based Drug Delivery
- Alzheimer's disease research and treatments
- Renal cell carcinoma treatment
- Sports injuries and prevention
- N-Heterocyclic Carbenes in Organic and Inorganic Chemistry
- Ginkgo biloba and Cashew Applications
- Effects and risks of endocrine disrupting chemicals
- Vascular Malformations Diagnosis and Treatment
- RNA Interference and Gene Delivery
- Polyomavirus and related diseases
- Tea Polyphenols and Effects
Tea Research Institute
2025
Zhejiang University
2017-2025
National Clinical Research Center for Digestive Diseases
2024-2025
Capital Medical University
2024-2025
Second Military Medical University
2025
Eastern Hepatobiliary Surgery Hospital
2025
Shenyang Pharmaceutical University
2020-2024
Jinzhou Medical University
2024
General Hospital of Shenyang Military Region
2022-2024
Southern Medical University
2024
Brain metastases (BrMs) are the leading cause of death in patients with solid cancers. BrMs exhibit a highly immunosuppressive milieu and poor response to immunotherapies; however, underlying mechanism remains largely unclear. Here, we show that upregulation HSP47 tumor cells drives metastatic colonization outgrowth brain by creating an microenvironment. HSP47-mediated collagen deposition niche promotes microglial polarization M2 phenotype via α2β1 integrin/nuclear factor κB pathway, which...
Combination therapy using distinct mode-of-action drugs has sparked a rapidly growing interest because this paradigm holds promise for improving the therapeutic efficacy of anticancer therapy. However, current drug combination refers to administering individual together, which is far from perfect regimen cancer patients. The aim work was demonstrate that synergistic delivery two chemotherapeutic in single nanoparticle reservoir could be achieved through rational chemical ligation followed by...
ZLDI-8 is an A disintegrin and metalloproteinase domain 17 (ADAM17) inhibitor that suppresses the shedding of Notch1 to intracellular (NICD). In previous studies, we found was able sensitize HCC sorafenib, but mechanism action remains unclear. The sensitizing effects were tested both in vitro vivo. EMT-related factors, sorafenib sensitivity-related proteins ECM-related gene expression assessed using immunohistochemistry, RTPCR Western blotting. Knockdown assays conducted determine...
To validate the safety and effectiveness of transarterial chemoembolization (TACE) combination with lenvatinib sintilimab in treating hepatocellular carcinoma (HCC) patients inferior vena cava (IVC) and/or right atrium (RA) tumor thrombosis (TT).This study retrospectively analyzed HCC IVC RA TT treated TACE combined plus sintilimab. Overall survival (OS), progression-free (PFS), objective response rate (ORR), disease control (DCR) were calculated to evaluate anti-tumor efficacy....
Hepatocellular carcinoma (HCC) is one of the leading causes cancer deaths worldwide. Significantly activated uridine nucleotide and fatty acid metabolism in HCC cells promote malignant proliferation immune evasion. Herein, it demonstrated that tripartite motif 65 (TRIM65) E3 ubiquitin-protein ligase, O-GlcNAcylated via O-GlcNAcylation transferase, highly expressed facilitated metabolic remodeling to accumulation products related uracil palmitic acid, driving progression HCC. Mechanistically,...
Aims Effective intervention for mild cognitive impairment (MCI) is key preventing dementia. As a neuroprotective agent, butylphthalide has the potential to treat MCI due Alzheimer disease (AD). However, pharmacological mechanism of from brain network perspective not clear. Therefore, we aimed investigate multimodal changes associated with treatment in AD. Methods A total 270 patients AD received either or placebo at ratio 1:1 1 year. was defined as decrease Alzheimer's Disease Assessment...
Background Inverse ratio ventilation theoretically increases oxygenation in obese patients. However, it is unknown whether the use of inverse prolongs safe apnea time during induction anesthesia. The primary objective our study was to compare between surgical patients receiving and conventional Methods This a prospective, randomized controlled trial. Forty who underwent elective operation under general anesthesia with endotracheal intubation were randomly allocated into (CRV) group ( n = 20)...
The efficacy of multitarget neuroprotective drug DL-3-n-butylphthalide (NBP) in improving cognitive function has been confirmed patients with vascular impairment without dementia. However, its symptomatic predementia phase Alzheimer's disease remains uncertain. This study aims to evaluate the and safety NBP mild (MCI) through a clinical randomised controlled trail.
Polymeric micelles are attractive nanocarriers for tumor-targeted delivery of paclitaxel (PTX). High antitumor efficacy and low toxicity require that PTX mainly accumulated in tumors with little drug exposure to normal tissues. However, many PTX-loaded micelle formulations suffer from stability, fast release, lack tumor-targeting capability the circulation. To overcome these challenges, we developed a micellar formulation consists sodium cholate (NaC) monomethoxy poly (ethylene...
Multidrug resistance (MDR) is considered as a primary hindrance for paclitaxel failure in non-small cell lung cancer (NSCLC) patients, which P-glycoprotein (P-gp) overexpressed and the PI3K/Akt signaling pathway dysregulated. Previously, we designed synthesized DHW-221, dual PI3K/mTOR inhibitor, exerts remarkable antitumor potency NSCLC cells, but its effects underlying mechanisms resistant cells remain unknown. Here, reported first time that DHW-221 had favorable antiproliferative activity...
The aim of this study was to estimate the benchmark dose (BMD) for pancreas dysfunction caused by cadmium (Cd) exposure in smelters. Smelter workers who had been exposed Cd more than 1 year and matching nonoccupationally subjects were asked participate study. Urinary (UCd) used as a biomarker exposure, serum insulin amylase biomarkers pancreatic effects. In study, lower smelter subjects. A significant dose-response relationship with UCd displayed. BMDs terms urinary corrected creatinine...
Introduction: ZLDI-8, which has a relatively strong antitumor activity, is an inhibitor of ADAM-17 and acts on the Notch signaling pathway. To further optimize its structure improve series derivatives ZLDI-8 was synthesized. NY-2 most effective derivative based preliminary activity screening in vitro, with no obvious toxicity after administration vivo . Method: The study aimed to determine pharmacokinetics, tissue distribution, hepatotoxicity, nephrotoxicity, compound non-small cell lung...
Abstract Background Tendons are important dense fibrous structures connecting muscle to bone, and tendon stem cells (TDSCs) affect their repair regeneration. The role of TDSC-derived exosomes (TDSC-Exos) is still being unexplored; therefore, this study aimed investigate the protective effect TDSC-Exos on tenocytes. Methods TDSCs tenocytes were all derived from Sprague Dawley (SD) rats. expression positive negative markers detected by flow cytometry, multi-differentiation ability was also...
Neonatal pig islet-like cell clusters (NICC) are an attractive source of insulin-producing tissue for potential transplantation treatment type 1 diabetic patients. However, a considerable loss NICC after their due to apoptosis resulted from islet isolation and instant blood-mediated inflammatory reaction remains be overcome.EGM2 medium depleted with hydrocortisone supplemented 50 mmol/L isobutylmethylxanthine, 10 nicotinamide, glucose was used culture at day 1, the changed every other day....