A5065562998- Catalytic C–H Functionalization Methods
- Nanoparticle-Based Drug Delivery
- RNA Interference and Gene Delivery
- Advanced Polymer Synthesis and Characterization
- Block Copolymer Self-Assembly
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Synthesis and Catalytic Reactions
- Nanoplatforms for cancer theranostics
- Advanced biosensing and bioanalysis techniques
- Catalytic Cross-Coupling Reactions
- Axial and Atropisomeric Chirality Synthesis
- Machine Learning in Materials Science
- Molecular spectroscopy and chirality
- Catalytic Alkyne Reactions
- Cyclopropane Reaction Mechanisms
- Surfactants and Colloidal Systems
- Sulfur-Based Synthesis Techniques
- Multicomponent Synthesis of Heterocycles
- Advanced Drug Delivery Systems
- Phenothiazines and Benzothiazines Synthesis and Activities
- Chemical Reactions and Isotopes
- Asymmetric Hydrogenation and Catalysis
- biodegradable polymer synthesis and properties
- Marine Toxins and Detection Methods
Zhejiang University
2014-2025
Hangzhou First People's Hospital
2025
Westlake University
2025
Donghua University
2024
Anhui Normal University
2010-2023
Nankai University
2015-2022
Collaborative Innovation Center of Chemical Science and Engineering Tianjin
2015-2022
Wuhu Institute of Technology
2019-2021
Shenzhen University
2019
Indiana University School of Medicine
2018
Abstract The therapeutic index for chemotherapeutic drugs is determined in part by systemic toxicity, so strategies dose intensification to improve efficacy must also address tolerability. In addressing this issue, we have investigated a novel combinatorial strategy of reconstructing drug molecule and using sequential drug-induced nanoassembly fabricate supramolecular nanomedicines (SNM). Using cabazitaxel as target agent, established that individual synthetic prodrugs tethered with...
The availability of precisely modulated chemical modifications dramatically affects the physicochemical properties pristine drugs and should facilitate amphiphilic self‐assembly prodrugs into supramolecular nanoprodrugs (SNPs). However, rationally designing such to achieve favorable clinical outcomes still remains a challenge. Here, library through site‐specific attachment variety lipophilic moieties antitumor agent SN‐38 (7‐ethyl‐10‐hydroxycamptothecin) is constructed. Taking advantage role...
Direct construction of N–C axial chirality via Pd-catalyzed atroposelective C–H olefination N-arylindoles is reported. The crucial role chiral amino acid as a cocatalyst in the regio- and stereocontrol has been disclosed. In this reaction, wide range arylindoles functional alkenes could be well tolerated. Moreover, practicality synthetic value process were demonstrated by divers simple transformations products.
Drug-loaded nanoparticles (NPs) are of particular interest for efficient cancer therapy due to their improved drug delivery and therapeutic index in various types cancer. However, the encapsulation many chemotherapeutics into NPs is often hampered by unfavorable physicochemical properties. Here, we employed a reform strategy construct small library SN-38 (7-ethyl-10-hydroxycamptothecin)-derived prodrugs, which phenolate group was modified with variety hydrophobic moieties. This...
Flavonoids are natural polyphenolic compounds produced by many aquatic plants and released in their environments. In this study, the effects of several flavonoids on cyanobacterial Microcystis aeruginosa, especially relation to cell growth, photosynthetic activity, morphology, membrane integrity, were investigated. Significant growth inhibition was observed when cyanobacteria exposed three flavonoids, namely, 5,4'-dihydroxyflavone (DHF), apigenin, luteolin. Luteolin reduced effective quantum...
Combination therapy using distinct mode-of-action drugs has sparked a rapidly growing interest because this paradigm holds promise for improving the therapeutic efficacy of anticancer therapy. However, current drug combination refers to administering individual together, which is far from perfect regimen cancer patients. The aim work was demonstrate that synergistic delivery two chemotherapeutic in single nanoparticle reservoir could be achieved through rational chemical ligation followed by...
Synthesis of ingenious nanoassemblies is pursued in materials science. Herein, the situ synthesis self-assembled blends AB/BAB block copolymers poly(ethylene glycol)-block-polystyrene/polystyrene-block-poly(ethylene glycol)-block-polystyrene (PEG-b-PS/PS-b-PEG-b-PS) via two-macro-RAFT agent comediated dispersion polymerization reported. The strategy combines advantages polymer blending and polymerization-induced self-assembly. Following this strategy, various PEG-b-PS/PS-b-PEG-b-PS such as...
Nanomedicines have been extensively explored for cancer treatment, and their efficacies arguably proven in various cell-derived xenograft (CDX) mouse models. However, they generally fail to show such therapeutic advantages patients because of the huge pathological differences between human tumors CDX Methods: In this study, we fabricated colloidal ultrastable nanomedicines from polymeric prodrugs compared hepatocellular carcinoma (HCC) clinically relevant patient-derived (PDX) models, which...
The synergistic combination of two or more chemotherapeutics frequently requires packaging in single delivery vehicles for the sequential release each substance a predictable manner. Here, we demonstrate first time that rational engineering prodrug cocktail into polymeric nanoparticles (NPs) can enable controllable Exploiting combretastatin-A4 (CA4, 1) as model antiangiogenesis agent, ester derivatives, 2 and 3, tethered with saturated fatty acids (butanoic heptanoic acid respectively) were...
PEF synthesized by non-metallic catalyst (DBU) exhibited rapid melt crystallization in both non-isothermal and isothermal conditions.
Abstract Development of a sophisticated nanotherapeutic platform to deliver potent agents effectively and safely desired tumor sites remains challenging. Cabazitaxel (CTX) holds particular interest for clinical use because its ability overcome the drug resistance caused by other taxane drugs. However, investigations this agent have been met with only limited success due high toxicity in patients, thus exploration CTX as safe chemotherapeutic tremendous challenge. Here, it is reported that...
tRNA-derived fragments (tRFs), a novel class of small non-coding RNAs cleaved from transfer RNAs, have been implicated in tumor regulation. In this study, the role specific tRF, HCETSR is investigated, which significantly downregulated hepatocellular carcinoma (HCC) and correlates with advanced burden higher HCC mortality. Functional analyses revealed that inhibits malignancy serves as an independent predictor poor prognosis. Mechanistically, SPTBN1/catenin complex axis regulated by...
Herein, we develop the first one‐pot amide synthesis from aldehyde/ketone and amino acids via transaminative amidation reaction method requires no catalyst or promoters, by allowing a concise access to structurally diverse amides lactams with good efficiency. This transformation could also proceed smoothly direct use of ether solvent as formylated reagent in stead formylic acid, thus furnishing an unique formamides. The underlying principles this was rationalized series mechanistic studies,...
The rhodium(III)-catalyzed tunable oxidative cyclization of readily available N-tosylacrylamides and diazo compounds is presented, which offers a novel method for the selective construction fully substituted α-pyrones furans in regiospecific manner by employing acylsulfonamide group as versatile situ removable directing group.
A silver-catalyzed, K 2 S O 8 -mediated protocol to access the regioselective acylarylation of unactivated alkenes was reported.
We here provide the first report on construction of nanoparticles formulating highly potent cytotoxic therapeutics using albumin. Maytansinoid DM1 can be efficiently integrated into albumin nanoparticles, resulting in remarkable alleviation vivo drug toxicity and expanding repertoire technology available for cancer therapy.
An efficient protocol for the synthesis of isoquinolinediones by Rh<sup>III</sup>-catalyzed C–H activation/annulation/decarboxylation <italic>N</italic>-tosylbenzamides with diazo compounds is reported.
Herein, we present the Pd(II)-catalyzed atroposelective C–H acyloxylation strategy for assembly of biaryl aldehyde atropoisomers using readily available amino acids as catalytic auxiliary and chiral pool. This exhibits a broad substrate scope with good yield (≤90%) excellent enantioselectivity (≤99%), furnishing functionalized aldehydes through direct asymmetric oxidation. The application utility this method was demonstrated by concise synthesis kind atropoisomeric amino-phenol...
We herein reprogrammed axial ligands of platinum(<sc>iv</sc>) prodrugs, conferring the constructed prodrug entities with ability to self-assemble in aqueous solution.
Abstract Drug‐loaded nanoparticles (NPs) are of particular interest for efficient cancer therapy due to their improved drug delivery and therapeutic index in various types cancer. However, the encapsulation many chemotherapeutics into NPs is often hampered by unfavorable physicochemical properties. Here, we employed a reform strategy construct small library SN‐38 (7‐ethyl‐10‐hydroxycamptothecin)‐derived prodrugs, which phenolate group was modified with variety hydrophobic moieties. This...
The first Pd(<sc>ii</sc>)-catalyzed atroposelective dual C–H annulative strategy for diverse synthesis of functionalized axially chiral biaryls was developed.