Runxiu Zhu
A5112837698- Acute Ischemic Stroke Management
- Neurological Disease Mechanisms and Treatments
- Venous Thromboembolism Diagnosis and Management
- Cerebrovascular and Carotid Artery Diseases
- Antiplatelet Therapy and Cardiovascular Diseases
- Stroke Rehabilitation and Recovery
- Neurological Disorders and Treatments
- DNA Repair Mechanisms
- Multiple Sclerosis Research Studies
- Medicinal Plants and Bioactive Compounds
- MicroRNA in disease regulation
- Bacterial Genetics and Biotechnology
- Cancer-related molecular mechanisms research
- Intracerebral and Subarachnoid Hemorrhage Research
- Autoimmune Neurological Disorders and Treatments
- Cancer therapeutics and mechanisms
- Barrier Structure and Function Studies
- Gout, Hyperuricemia, Uric Acid
- Metabolomics and Mass Spectrometry Studies
- Neurogenesis and neuroplasticity mechanisms
- Sphingolipid Metabolism and Signaling
- Protein Degradation and Inhibitors
- Eating Disorders and Behaviors
- Treatment of Major Depression
- Whipple's Disease and Interleukins
China Academy of Chinese Medical Sciences
2024
Inner Mongolia People's Hospital
2016-2023
Jilin University
2023
First Hospital of Jilin University
2023
Thales (Portugal)
2020-2021
Fourth Affiliated Hospital of Harbin Medical University
2020
Harbin Medical University
2020
Inner Mongolia University
2016
Background and Purpose: Edaravone dexborneol, comprised of 2 active ingredients, edaravone (+)-borneol, has been developed as a novel neuroprotective agent with synergistic effects antioxidant anti-inflammatory in animal models. The present clinical trial aimed at testing the dexborneol versus on 90-day functional outcome patients acute ischemic stroke (AIS). Methods: A multicenter, randomized, double-blind, comparative, phase III was conducted 48 hospitals China between May 2015 December...
Importance Previous studies suggested a benefit of argatroban plus alteplase (recombinant tissue-type plasminogen activator) in patients with acute ischemic stroke (AIS). However, robust evidence trials large sample sizes is lacking. Objective To assess the efficacy for AIS. Design, Setting, and Participants This multicenter, open-label, blinded end point randomized clinical trial including 808 AIS was conducted at 50 hospitals China enrollment from January 18, 2019, through October 30,...
Although platelet-derived growth factor receptor beta (PDGFR-β) mediates the recruitment of vascular pericytes into ischemic lesion to restore blood-brain barrier (BBB) dysfunction, its mechanisms still remain elusive. Compared with control PDGFR-βfloxed/floxed mice (Floxed), postnatally induced systemic PDGFR-β knockout (Esr-KO) not only showed severe brain edema, neurologic functional deficits, decreased expression tight junction (TJ) proteins, abundant endothelial transcytosis, and...
Importance Recombinant human prourokinase (rhPro-UK) is a thrombolytic agent that has shown promising findings in phase 2 clinical trial patients with acute ischemic stroke (AIS). Objective To evaluate the efficacy and safety of rhPro-UK thrombolysis within 4.5 hours symptom onset AIS. Design, Setting, Participants This randomized, alteplase-controlled, open-label, 3 was conducted from May 2018 to 2020 at 35 medical centers China. A total 684 were screened 674 enrolled. Included aged 18 80...
To investigate potential associations between carotid artery stenosis and cognitive impairment among patients with acute ischemic stroke to provide important clinical implications. We measured the degree of recorded Mini-Mental State Examination score (MMSE) at admission in 3116 patients. The association assessed by MMSE was tested using multivariate regression analysis. Other variables interest were also studied. After adjusting for age, gender, education level, marriage, alcohol use,...
Ischemic stroke is a leading cause of morbidity and mortality. Thrombolytic therapy improves disability survival rates; however, to be effective, it must given within 4.5 h onset. Moreover, thrombolytic frequently contraindicated. Therefore, alternative therapeutic options are required. In China, cinepazide maleate injection has been shown improve the cerebral collateral circulation further reduce in patients; very few studies investigating this have conducted date. study aimed confirm...
Abstract Increasing evidence indicates that microRNAs (miRNAs) participate in the regulation of chemoresistance a variety cancers including glioma. However, molecular mechanism underlying development glioma is not well understood. The aim present study was to explore role miRNAs chemosensitivity cells and mechanism. By microarray qRT-PCR, we observed significant down-regulation microRNA-302c (miR-302c) temozolomide (TMZ)-resistant human tissues/cells. low expression miR-302c closely...
Purpose This study aimed to analyze the severity of condition and prognosis patients with anti-gamma-aminobutyric-acid type B receptor (anti-GABA R) encephalitis tumors. Methods Patients anti-GABA R admitted one two hospitals from 2020 2022 were enrolled divided into tumor non-tumor groups. The clinical characteristics, severity, treatment options, groups compared analyzed. Results Eighteen included, ten whom had comparison characteristics showed that rates status epilepticus coma...
Ischemic stroke is a major cause of disability and death worldwide. A narrow therapeutic window profoundly constrained the utilization alteplase. To investigate effects safety intravenous recombinant human prourokinase (rhPro-UK) in patients with acute ischemic (AIS) 4.5–6 h time windows. We conducted phase IIa, randomized, open-label multicenter clinical trial. Between 4.5 6 after onset AIS, were randomly administrated to receive rhPro-UK at 50 mg or 35 dose. The primary endpoint was...
Depression can seriously affect the quality of life type 2 diabetes mellitus (T2DM) patients after stroke. However, there were still no objective methods to diagnose T2DM with poststroke depression (PSD). Therefore, we conducted this study deal problem.Gas chromatography-mass spectroscopy (GC-MS)-based metabolomics profiling method was used profile urinary metabolites from 83 nondepressed stroke and 101 PSD. The orthogonal partial least-squares discriminant analysis explore metabolic...
Agomelatine was a novel and melatonergic antidepressant. The present study conducted to find out whether age an important factor for agomelatine in treating depressed type 2 diabetes mellitus (T2DM) patients. In total, 193 T2DM patients were included. There 84 ranged from 27 years old 49 (age phase I) (n = 44 receiving agomelatine, n 40 paroxetine or fluoxetine), 109 50 70 II) 56 53 fluoxetine). Hamilton Depression Rating Scale (HDRS) score, Anxiety (HARS) fasting plasma glucose (FPG),...
RstB/RstA is an uncharacterized Escherichia coli two-component system, the regulatory effects of which on E. cell cycle remain unclear. We found that doubling time and average number replication origins per in ΔrstB mutant were same as wild-type, ΔrstA was 18.2% lower than wild-type cells. The times 34 min, 35 40 min for ΔrstB, strains, respectively. Ectopic expression RstA from plasmid pACYC-rstA partly reversed phenotypes. amount initiator protein DnaA reduced by 40% compared with but...
Previous studies have shown that human immunodeficiency virus (HIV) infection is associated with hypertension; however, the results of these are affected by a variety confounding factors. There no definite evidence to prove causal relationship between two This study aimed investigate HIV and hypertension. A two-sample Mendelian randomization (MR) was conducted using genome-wide association (GWAS) statistics published online. The data were collected mainly from OpenGWAS FinnGen databases....
Objective: To investigate the blood pressure change in patients with acute ischemic stroke (AIS) and hypertension treated cinepazide maleate injection. Methods: This was a subgroup analysis of post-marketing clinical confirmation study injection for stroke: randomized, double-blinded, multicenter, placebo-parallel controlled trial, which conducted China from August 2016 to February 2019. Eligible fulfilled inclusive criteria anterior circulation National Institutes Health Stroke Scale...
Hyperuricemia is closely related to acute ischemic stroke (AIS). In our study, we investigated the pattern of miRNA-155-5p and miRNA-124-5p expressions along with its clinical application in AIS hyperuricemia patients a rat model by RT-qPCR. The was established, found that levels were increased serum, brain kidney tissues compared those normal rats. We proved also elevated AIS, accompanied enrolled from department neurology Inner Mongolia People’s Hospital (IMPH). mainly associated neuronal...