A5085249149- Anesthesia and Neurotoxicity Research
- Malaria Research and Control
- Intensive Care Unit Cognitive Disorders
- Mosquito-borne diseases and control
- Anesthesia and Sedative Agents
- Invertebrate Immune Response Mechanisms
- Inflammasome and immune disorders
- Traumatic Brain Injury and Neurovascular Disturbances
- Traditional Chinese Medicine Analysis
- Prostate Cancer Treatment and Research
- Respiratory viral infections research
- Vector-borne infectious diseases
- Histone Deacetylase Inhibitors Research
- Peptidase Inhibition and Analysis
- Pediatric Hepatobiliary Diseases and Treatments
- Cytokine Signaling Pathways and Interactions
- Macrophage Migration Inhibitory Factor
- Complement system in diseases
- Dermatology and Skin Diseases
- Ubiquitin and proteasome pathways
- Nuclear Receptors and Signaling
- Cancer Mechanisms and Therapy
- Diabetes Treatment and Management
- Animal Virus Infections Studies
- Viral gastroenteritis research and epidemiology
Affiliated Hospital of Southwest Medical University
2020-2025
Center for Excellence in Brain Science and Intelligence Technology
2025
Shanghai Institutes for Biological Sciences
2025
China Medical University
2010-2024
Kanazawa Medical University
2023
First Affiliated Hospital of Anhui Medical University
2023
Anhui Medical University
2023
Inner Mongolia University for Nationalities
2022
Inner Mongolia People's Hospital
2021
West China Medical Center of Sichuan University
2021
TMEM16A Ca2+-activated Cl- channels are expressed in pancreatic acinar cells and participate inflammation-associated diseases. Whether contributes to the pathogenesis of acute pancreatitis (AP) remains unknown. Here, we found that increased expression tissue was correlated with interleukin-6 (IL-6) level serum a cerulein-induced AP mouse model. IL-6 treatment promoted AR42J via receptor (IL-6R)/signal transducers activators transcription 3 (STAT3) signaling pathway. In addition,...
Recently somatic mutations of KCNJ5, ATP1A1, ATP2B3, and CACNA1D have been identified in patients with aldosterone-producing adenoma (APA). The present study sequenced the DNA tissues blood samples from Chinese APA for gene mutations.Among 114 patients, 86 (75.4%) were KCNJ5 mutations, including 3 previously reported (G151R, L168R, T158A) 2 other unreported mutations. One patient presented both a point mutation (E147) an insertion mutation, whereas another had 36-base duplication,...
Atopic dermatitis (AD), a chronic inflammatory skin disease, is characterized by intense itching and recurrent eczematous lesions. Sulforaphane known to attenuate oxidative stress, tissue or cell damage in cerebral ischemia, brain inflammation intracerebral hemorrhage. In the present study, 2,4‑dinitrochlorobenzene (DNCB)‑induced AD mouse model was developed, ear thickness, score, eosinophil count, mast infiltration, serum IgE levels were measured DNCB‑induced sulforaphane‑treated groups...
Abstract Atopic dermatitis (AD) is a chronic inflammatory cutaneous disorder with few treatment options. Dynamin‐related protein 1 (Drp1)‐dependent mitochondrial fission contributes to the activation of NLRP3 inflammasome, and inhibiting Drp1 has been become an attractive therapeutic strategy for diseases. This study aimed investigate effects inhibitor mdivi‐1 on experimental AD. We firstly detected primary human keratinocytes in cocktail‐induced AD‐related inflammation vitro. Results showed...
Abstract Acute lung injury (ALI) is featured with a robust inflammatory response. Angiopoietin‐like protein 2 (ANGPTL2), pro‐inflammatory protein, complicated various disorders. However, the role of ANGPTL2 in ALI remains to be further explored. The mice and MH‐S cells were administrated lipopolysaccharide (LPS) evoke vivo vitro. mechanism ANGPTL was investigated by haematoxylin–eosin, measurement wet/dry ratio, cell count, terminal deoxynucleotidyl transferase deoxyuridine triphosphate...
Background It is well-known that ultraviolet B (UVB) causes cataracts by inducing pyroptosis and the production of reactive oxygen species (ROS) in human lens epithelial cells (HLECs). The transcription factor E2F1 (E2F1) serves as a positive regulator disrupted pathways involved histone modification cell cycle regulation. However, its function UVB-treated HLECs remains unknown. Purpose: This study aims to investigate HLECs, with particular focus on interaction NLRP3 impact oxidative stress...
Recombinant adeno-associated viruses (AAVs) have been widely used for gene delivery and therapy. However, certain AAV serotypes exhibited distinct transduction patterns among different mouse strains or between mice non-human primates (NHPs). These variations prompted us to investigate the tropism of 21 capsid variants using barcoded libraries tissues in C57BL/6 BALB/c mice, as well crab-eating macaques. Our study unveiled that tropisms varied significantly species, particularly such AAV4,...
The effect of sevoflurane on the nervous system is controversial. As an adjuvant anesthetic, dexmedetomidine has a protective role in various nerve-injury diseases. We investigated injury to developing brain induced by anesthesia, and if autophagy mitochondrial damage are involved neuroprotective effects dexmedetomidine.Pregnant rats gestational day 20 were exposed 3% for 4 hours. Saline injected intraperitoneally 15 minutes before exposure or control gas. Bilateral hippocampi harvested...
As one of the most popular anesthetics, sevoflurane is widely used in pediatric anesthesia. Unfortunately, an increasing number studies have demonstrated that has potential neurotoxic effects on developing brain and cognition, even adolescence. Connexin 43 (Cx43) been documented to contribute cognitive dysfunction. The present study hypothesized Cx43 may participate sevoflurane-induced neuroinjury investigated underlying mechanisms young Sprague Dawley (SD) rats. Seven-day-old SD rats (P7)...
Numerous studies have demonstrated that general anesthetics might damage the nervous system, thus, effect of on developing brain has attracted much attention. Dexmedetomidine (Dex) exhibits a certain neuroprotective effect, but mechanism is obscure. In our study, pregnant rats gestational day 20 (G20) were exposed to 3% sevoflurane for 2 h or 4 h, and neuronal apoptosis in hippocampal CA1 region offspring was detected by quantification TUNEL positive cells cleaved-caspase3 (cl-caspase3)....
Many studies have reported that sevoflurane can increase neuronal apoptosis and result in cognitive deficits rodents. Although neurotoxicity may be associated with mitochondrial dysfunction oxidative stress, the exact mechanism remains unclear. In order to evaluate potential treatment therapies, we studied effects of hemin on neonatal rat exposure.Postnatal day (P) seven rats were assigned randomly four groups; (1) group C: non-anesthesia, (2) H: intraperitoneal (50 mg kg-1) days 5 6, (3) S:...
Objective The purpose of this study was to examine the intervention effect radial extracorporeal shock wave combined with ultrashort diathermy on immobilization-induced fibrosis and contracture muscle. Design groups included male rabbits for group (control group). To cause joint contracture, underwent plaster fixation a left knee at full extension. After immobilization 4 wks, all were randomly divided into five groups: model group, natural recovery treatment group. All effects assessed by...
Abstract Hepatocellular carcinoma is a highly fatal disease and threatens human health seriously. Fluid shear stress (FSS), which caused by the leakage of plasma from abnormally permeable tumor blood vessels insufficient lymphatic drainage, has been identified as contributing pathologically to cancer metastasis. Autophagy epithelial–mesenchymal transition (EMT) are both reported be involved in cell migration invasion, but little revealed about interaction between autophagy EMT under...
Nur77 is an orphan nuclear receptor implicated in the regulation of a wide range biological processes, including maintenance systemic blood vessel homeostasis. Although known to be expressed lung, its role regulating pulmonary vascular functions remains entirely unknown. In this study, we found that at high levels and expression markedly upregulated response LPS administration. While vasculature mice lacked appeared function normally under homeostatic conditions, observed dramatic decrease...
Clinically, biliary obstruction is often accompanied by progressive inflammation. Dehydroandrographolide (DA) possesses anti-inflammatory properties. However, the activities of DA in cholestatic liver injury remain unclear.Mice were administered with intraperitoneal injection after bile duct ligation (BDL) on day 1. Then mice subjected to an ileocecal vein lipopolysaccharide (LPS). Liver function markers, histology, pro-inflammatory cytokine levels, NF-κB activation and fibrosis formation...
Ca2+ -activated Cl- channels (Ano1 channels) contribute to the pathogenesis of colorectal cancer. Honokiol is known inhibit cell proliferation and tumour growth in However, molecular target honokiol remains unclear. This study aimed investigate whether inhibited cancer by targeting Ano1 channels.Patch-clamp techniques were performed effect on currents HEK293 cells overexpressing Ano1- or Ano2-containing plasmids human carcinoma SW620 cells. Site-directed mutagenesis was used identify...
Abstract The histone acetyltransferase MOF (KAT8) is mainly involved in the acetylation of H4 at lysine 16 (H4K16) and some non‐histone proteins. expression level significantly reduced many cancers, however biological function its underlying mechanism are still elusive hepatocellular carcinoma (HCC). Estrogen receptor α (ERα) has been considered as a tumor suppressor HCC. Here, we demonstrated that HCC samples, positively correlated with ERα. interacts ERα, participates ERα K266, K268, K299,...
Type 2 diabetes (T2D) is a common disorder characterized by chronic low-grade inflammation. In the present study, expression levels of nuclear receptor subfamily 4 group A member 1 (NR4A1) and correlation with inflammatory cytokine production free fatty acids (FFAs) in patients T2D healthy participants were investigated. NR4A1 peripheral blood mononuclear cells (PBMCs) from (n=30) controls (n=34) analyzed. addition, fasting glucose (FBG), plasma insulin (FIN), FFAs, total cholesterol (TC),...
The relaxin family peptides have been shown to exert several beneficial effects on the heart, including anti-apoptosis, anti-fibrosis, and anti-hypertrophy activity. Understanding their regulation might provide new opportunities for therapeutic interventions, but molecular mechanism(s) coordinating expression in heart remain largely obscured. Previous work demonstrated a role orphan nuclear receptor Nur77 regulating cardiomyocyte apoptosis. We therefore investigated hopes of identifying...