A5100444834- Anesthesia and Neurotoxicity Research
- Intensive Care Unit Cognitive Disorders
- Anesthesia and Sedative Agents
- Neuroscience and Neuropharmacology Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Stress Responses and Cortisol
- Neurological Disease Mechanisms and Treatments
- EEG and Brain-Computer Interfaces
- Adenosine and Purinergic Signaling
- Ion channel regulation and function
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiac Ischemia and Reperfusion
- Neural and Behavioral Psychology Studies
- Traumatic Brain Injury and Neurovascular Disturbances
- Cancer, Stress, Anesthesia, and Immune Response
- ECG Monitoring and Analysis
- Ocular Oncology and Treatments
- Nerve injury and regeneration
- Neural dynamics and brain function
- Renal function and acid-base balance
- Mesenchymal stem cell research
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Neuroscience of respiration and sleep
- Digital Transformation in Industry
- Connexins and lens biology
Second Affiliated Hospital of Xi'an Jiaotong University
2019-2024
University of Duisburg-Essen
2024
China Medical University
2007-2023
First Affiliated Hospital of Hebei Medical University
2023
Hebei Medical University
2023
Sheng Jing Hospital
2021
Hebei North University
2019
Jinan University
2011
Chongqing Medical University
2010
The Graduate University for Advanced Studies, SOKENDAI
2007
N- methyl-d-aspartate (NMDA) receptors are important components of pain processing. Ketamine and Mg2+ block NMDA might therefore be useful analgesics, combinations ketamine provide more effective analgesia. We investigated their interactions at receptors. Xenopus oocytes, expressing NR1/NR2A or NR1/NR2B glutamate receptors, were studied. The effects Mg2+, racemic its isomers, the combination S(+)-ketamine on signaling determined. alone inhibited noncompetitively (half-maximal inhibitory...
ATP represents a major gliotransmitter that serves as signaling molecule for the cross talk between glial and neuronal cells. has been shown to be released by astrocytes in response number of stimuli under nonischemic conditions. In this study, using luciferin-luciferase assay, we found mouse primary culture also exhibit massive release ischemic stress mimicked oxygen-glucose deprivation (OGD). Using biosensor technique, local concentration at surface single was increase around 4 muM. The...
The effect of sevoflurane on the nervous system is controversial. As an adjuvant anesthetic, dexmedetomidine has a protective role in various nerve-injury diseases. We investigated injury to developing brain induced by anesthesia, and if autophagy mitochondrial damage are involved neuroprotective effects dexmedetomidine.Pregnant rats gestational day 20 were exposed 3% for 4 hours. Saline injected intraperitoneally 15 minutes before exposure or control gas. Bilateral hippocampi harvested...
As one of the most popular anesthetics, sevoflurane is widely used in pediatric anesthesia. Unfortunately, an increasing number studies have demonstrated that has potential neurotoxic effects on developing brain and cognition, even adolescence. Connexin 43 (Cx43) been documented to contribute cognitive dysfunction. The present study hypothesized Cx43 may participate sevoflurane-induced neuroinjury investigated underlying mechanisms young Sprague Dawley (SD) rats. Seven-day-old SD rats (P7)...
The neurotoxic effects of sevoflurane anesthesia on the immature nervous system have aroused public concern, but specific and mechanism remain poorly understood. Pyroptosis caused by activation NLRP3 inflammasome is pivotal for cell survival acts as a key player in cognitive impairment. This study was carried out to determine critical role high-mobility group box 1 (HMGB1) sevoflurane-induced On gestational day 20 (G20), 3% administered 4 h pregnant rats. hippocampus cerebral cortex...
Numerous studies have demonstrated that general anesthetics might damage the nervous system, thus, effect of on developing brain has attracted much attention. Dexmedetomidine (Dex) exhibits a certain neuroprotective effect, but mechanism is obscure. In our study, pregnant rats gestational day 20 (G20) were exposed to 3% sevoflurane for 2 h or 4 h, and neuronal apoptosis in hippocampal CA1 region offspring was detected by quantification TUNEL positive cells cleaved-caspase3 (cl-caspase3)....
Background: Considerable evidences support the finding that anesthesia reagent isoflurane increases neuronal cell death in young rats. Recent studies have shown dexmedetomidine can reduce isoflurane-induced injury, but mechanism remains unclear. We investigated whether cause neurotoxicity to central nervous system by regulating N-methyl-D-aspartate receptor (NMDAR) and excitatory amino acid transporter1 (EAAT1) Furthermore, we examined if could decrease neurotoxicity. Methods: Neonatal rats...
Many studies have reported that sevoflurane can increase neuronal apoptosis and result in cognitive deficits rodents. Although neurotoxicity may be associated with mitochondrial dysfunction oxidative stress, the exact mechanism remains unclear. In order to evaluate potential treatment therapies, we studied effects of hemin on neonatal rat exposure.Postnatal day (P) seven rats were assigned randomly four groups; (1) group C: non-anesthesia, (2) H: intraperitoneal (50 mg kg-1) days 5 6, (3) S:...
To investigate the mechanism dexmedetomidine in relieving neurotoxicity of a developing brain induced by sevoflurane. Sprague-Dawley rats, 6 days old, were randomly divided into three groups. Rats control group inhaled with air after injection normal saline; rats sevoflurane injected saline and 3% for 2 h consecutive day; intraperitoneal 25 μ g/kg. WB results showed that mBDNF, pTrkB/TrkB, CREB significantly decreased hippocampus group, which are upregulated group. In proBDNF, P75NRT, RhoA...
Exploring the effective therapy for neonatal hypoxic-ischemic brain injury is an important goal. This study was designed to investigate how dexmedetomidine (DEX) contribute hypoxic injury. Developing Sprague-Dawley rat models of hypoxia/reoxygenation (H/R) were constructed simulate DEX treatment. Immunohistochemistry and western blot performed measure neuroglobin (Ngb) protein expression in hippocampal tissues. Hippocampal neuron apoptosis detected by Nissl staining TUNEL assay,...
Cognitive dysfunction following anesthesia with agents such as sevoflurane is a significant clinical problem, particularly in elderly patients. This study aimed to explore the protective effects of phytochemical syringaresinol (SYR) against sevoflurane-induced cognitive deficits aged Sprague-Dawley rats and determine underlying mechanisms involved. We assessed impact SYR on impairment, glial activation, neuronal apoptosis through behavioral tests (Morris water maze), immunofluorescence,...
In clinical experiments, the surface electromyogram (sEMG) recorded from low back muscle exhibit a strong presence of electrocardiogram (ECG). This study applied independent component analysis (ICA) to effectively suppress interference ECG in sEMG muscle. contrast existing ICA denoise techniques, which totally remove artifactual components, high-pass filter was proposed process ECG-dominated components prevent possible loss useful sEMG, and then, project all non-artifactual (including...
As a general anesthesia drug, sevoflurane has been found to be potentially neurotoxic the developing brain. Neuroglobin (Ngb) is novel oxygen-carrying globulin that demonstrated have neuroprotective effects in variety of central nervous system disorders. However, it unclear whether Ngb protective effect on nerve damage caused by sevoflurane. Therefore, this study was designed investigate and related mechanisms neural injury induced Pregnant rats gestational day 20 (G20) were exposed 3.5% for...
Uveal melanoma (UM) represents a rare tumor of the uveal tract and is associated with poor prognosis due to high risk metastasis. Despite advances in treatment UM, mortality rate remains high, dictating an urgent need for novel therapeutic strategies. The current study introduces first vivo analysis potential calcium electroporation (CaEP) compared electrochemotherapy (ECT) bleomycin patient-derived xenograft (PDX) model based on chorioallantoic membrane (CAM) assay. experiments were...
People vary in their responses to stress. The present study aimed investigate whether and how alpha frontal asymmetry (AFA) measured the resting state underlies individual differences psychological acute psychosocial stress (e.g., increases heart rate cortisol) induced by Trier social test. Forty-three healthy male adults were enrolled this study. results showed that AFA score negatively predicted both cortisol responses, is relatively higher right-frontal activity during was related a...
We propose to use real-time single-channel EEG signal quantify user enjoyment level elicited by media content. Selected time-frequency components from frontal were extracted and formed a statistical multivariate model predicting level. Frequency Theta, Alpha Beta bands at different time moments selected. found robust performance during 10-folds cross-validation with 100 repetitions. A high correlation of around 0.8 between predicted actual subjects was achieved. Considering various factors...
Our previous study has revealed that OEA promotes motor function recovery in the chronic stage of ischemic stroke. However, neuroprotective mechanism on after stroke still is unexplored. Therefore, aim this was to explore effects treatment angiogenesis, neurogenesis, and white matter repair peri-infarct region cerebral ischemia.The adult male rats were subjected 2 h middle artery occlusion. The treated with 10 30 mg/kg or vehicle daily starting from day ischemia induction until they...
The purpose of this study was to investigate the effect naringin on lipopolysaccharide (LPS)-induced activation BV2 microglia and inflammatory factor release, mechanism involved. Different concentrations were used pretreat cells for 30 min, after which they stimulated with 100 ng/mL LPS different durations. levels NO, IL-1β TNF-α in cell culture medium determined ELISA Griess method. mRNA expressions RT-PCR. Changes ERK p65/NF-κB signaling pathway proteins assayed Western blotting. After 12...