A5093676388- Microfluidic and Bio-sensing Technologies
- Microbial Inactivation Methods
- Cancer Genomics and Diagnostics
- Cutaneous Melanoma Detection and Management
- Veterinary Oncology Research
- Ocular Oncology and Treatments
- Polyomavirus and related diseases
University of Duisburg-Essen
2024
Despite recent advancements in the diagnosis and treatment of uveal melanoma (UM), its metastatic rate remains high is accompanied by a highly dismal prognosis, constituting an unmet need for development novel adjuvant therapeutic strategies. We established vivo chick chorioallantoic membrane (CAM)-based UM xenograft model from UPMD2 UPMM3 cell lines to examine feasibility improvement selection drug candidates. The efficacy calcium electroporation (CaEP) with 5 or 10 mM chloride (Ca)...
Uveal melanoma (UM) represents a rare tumor of the uveal tract and is associated with poor prognosis due to high risk metastasis. Despite advances in treatment UM, mortality rate remains high, dictating an urgent need for novel therapeutic strategies. The current study introduces first vivo analysis potential calcium electroporation (CaEP) compared electrochemotherapy (ECT) bleomycin patient-derived xenograft (PDX) model based on chorioallantoic membrane (CAM) assay. experiments were...
Uveal melanoma (UM) is the most common intraocular tumor in adults, and nearly 50% of patients develop metastatic disease with a high mortality rate. Therefore, development relevant preclinical vivo models that accurately recapitulate cascade crucial. We exploited chick embryo chorioallantoic membrane (CAM) xenograft model to quantify both experimental spontaneous metastasis by qPCR analysis. Our study found transplanted UM cells spread predominantly early liver, reflecting primary site...