A5034538984- Anesthesia and Pain Management
- Anesthesia and Sedative Agents
- Cardiac, Anesthesia and Surgical Outcomes
- Receptor Mechanisms and Signaling
- Anesthesia and Neurotoxicity Research
- Ion channel regulation and function
- Pain Management and Opioid Use
- Neuroscience and Neuropharmacology Research
- Neuropeptides and Animal Physiology
- Nausea and vomiting management
- Cancer, Stress, Anesthesia, and Immune Response
- Sphingolipid Metabolism and Signaling
- Global Health and Surgery
- Hemodynamic Monitoring and Therapy
- Eicosanoids and Hypertension Pharmacology
- Pain Mechanisms and Treatments
- Protein Kinase Regulation and GTPase Signaling
- Traumatic Brain Injury and Neurovascular Disturbances
- Airway Management and Intubation Techniques
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Opioid Use Disorder Treatment
- Enhanced Recovery After Surgery
- Blood transfusion and management
- Artificial Intelligence in Healthcare and Education
- Dental Anxiety and Anesthesia Techniques
University of Virginia
2015-2024
University of Virginia Health System
2011-2022
University of Virginia Hospital
2001-2021
University of Michigan
2021
Barro Colorado Island
2011-2020
University of Rwanda
2019-2020
Neurological Surgery
1998-2019
Washington State University
2019
Columbia University
2015-2017
Chongqing Electromechanical Holdings (China)
2017
Endothelium-derived relaxing factor (EDRF), identified as nitric oxide (NO), is derived from a guanidino nitrogen of L-arginine via its metabolism by synthase (NOS). Herein, we report the molecular cloning cDNA encoding constitutive calcium-calmodulin (Ca2+/CaM)-regulated (ECNOS). A full-length ECNOS clone was isolated screening bovine aortic endothelial cell library using fragment rat brain NOS (bNOS) cDNA. This has an open reading frame 3615 nucleotides 1205-amino acid protein. Membranes...
Background Intravenous infusion of lidocaine decreases postoperative pain and speeds the return bowel function. The authors therefore tested hypothesis that perioperative facilitates acute rehabilitation protocol in patients undergoing laparoscopic colectomy. Methods Forty scheduled to undergo colectomy were randomly allocated receive intravenous (bolus injection 1.5 mg/kg at induction anesthesia, then a continuous 2 mg.kg.h intraoperatively 1.33 for 24 h postoperatively) or an equal volume...
To characterize the beneficial effects of perioperative systemic lidocaine on length hospital stay, gastrointestinal motility, and inflammatory response after colorectal surgery.Surgery-induced stimulation plays a major role in development several postoperative disorders. Local anesthetics possess anti-inflammatory activity are thought to positively affect patients' outcome surgery. This double-blinded, randomized, placebo-controlled trial aimed evaluate provide insights into underlying...
A wealth of basic science data supports the hypothesis that surgical stress response increases likelihood cancer dissemination and metastasis during after surgery. Anesthetic management patient, therefore, could potentially influence long-term outcome. Preclinical suggest beneficial approaches might include selection induction drugs such as propofol, minimizing use volatile anesthetics, coadministration cyclooxygenase antagonists with systemic opioids. Retrospective clinical trials addition...
Animal studies suggest that regional anesthesia and optimal postoperative analgesia independently reduce cancer metastasis. Retrospective clinical reductions in recurrence of several types patients receiving perioperative neuraxial analgesia. Thus, the authors determined association between epidural undergoing colorectal surgery.After obtaining approval institutional review board, reviewed records 669 surgery January 2000 March 2007. Follow-up ended November 2008. The authors' primary...
In Brief BACKGROUND: Patients undergoing complex spine surgery frequently experience severe pain in the postoperative period. The combined opiate receptor agonist/N-methyl-D-aspartate antagonist methadone may be an optimal drug for these patients given probable involvement of N-methyl-D-aspartate systems mechanism opioid tolerance and hyperalgesia. METHODS: Twenty-nine multilevel thoracolumbar with instrumentation fusion were enrolled this prospective study randomized to receive either (0.2...
The use of lung-protective ventilation (LPV) strategies may minimize iatrogenic lung injury in surgical patients. However, the identification an ideal LPV strategy, particularly during one-lung (OLV), remains elusive. This study examines role ventilator management OLV and its impact on clinical outcomes.Data were retrospectively collected from hospital electronic medical record Society Thoracic Surgery database for subjects undergoing thoracic surgery with between 2012 2014. Mean tidal...
OBJECTIVE Perception of perioperative pain is influenced by various psychological factors. The aim this study was to determine the impact catastrophizing, anxiety, and depression on in-hospital opioid consumption, scores, quality recovery in adults who underwent spine surgery. METHODS Patients undergoing surgery were enrolled study, preoperatively completed questionnaires included verbal rating scale (VRS), Pain Catastrophizing Scale (PCS), Hospital Anxiety Depression (HADS), Oswestry...
Most anesthesiologists will experience at least one perioperative catastrophe over the course of their careers. Very little, however, is known about emotional impact these events and effects on both immediate long-term ability to provide care. In this study, we examined incidence catastrophes outcomes American anesthesiologists.We sent a self-administered postal survey 1200 randomly selected members Society Anesthesiologists. Participants were an advance letter, up 2 copies survey, reminder...
Chronic opioid use is a significant public health concern. Surgery risk factor for developing chronic use. Patients undergoing major spine surgery frequently are prescribed opioids preoperatively and may be at postoperatively. The aim of this study was to investigate the incidence perioperative factors associated with after surgery.The records patients who underwent elective University Virginia between March 2011 February 2016 were retrospectively reviewed. primary outcome through 12 months...
Background Protective ventilation may improve outcomes after major surgery. However, in the context of one-lung ventilation, such a strategy is incompletely defined. The authors hypothesized that putative protective regimen would be independently associated with decreased odds pulmonary complications thoracic Methods merged Society Thoracic Surgeons Database and Multicenter Perioperative Outcomes Group intraoperative data for lung resection procedures using across five institutions from 2012...
Background There is insufficient prospective evidence regarding the relationship between surgical experience and prolonged opioid use pain. The authors investigated association of patient characteristics, procedure, perioperative anesthetic course with postoperative consumption pain 3 months postsurgery. hypothesized that characteristics intraoperative factors predict Methods Eleven U.S. one European institution enrolled patients scheduled for spine, open thoracic, knee, hip, or abdominal...
Ketamine is increasingly used in pain therapy but may impair brain functions. Mood and cognitive capacities were compared after equianalgesic small-dose S(+)-, R(-)-, racemic ketamine healthy volunteers.Twenty-four subjects received intravenous 0.5 mg/kg racemic, 0.25 1.0 R(-)-ketamine a prospective, randomized, double-blind, crossover study. Hemodynamic variables, mood, assessed for 60 min.Transient increases blood pressure, heart rate, catecholamines similar administration of all drugs. At...
N- methyl-d-aspartate (NMDA) receptors are important components of pain processing. Ketamine and Mg2+ block NMDA might therefore be useful analgesics, combinations ketamine provide more effective analgesia. We investigated their interactions at receptors. Xenopus oocytes, expressing NR1/NR2A or NR1/NR2B glutamate receptors, were studied. The effects Mg2+, racemic its isomers, the combination S(+)-ketamine on signaling determined. alone inhibited noncompetitively (half-maximal inhibitory...
Although ketamine's primary site of action appears to be the phencyclidine receptor on N-methyl-D-aspartate (NMDA) complex, additional activity opiate and quisqualate receptors is suggested. Some phencyclidines have been shown interact with muscarinic receptors, but this has not determined for ketamine. We studied interaction between ketamine m1 receptor, most prominent subtype in cortex hippocampus. Receptors were expressed recombinantly Xenopus oocytes, intracellular Ca2+ release response...
Background Local anesthetics (LAs) have been shown to inhibit human polymorphonuclear neutrophil (hPMN) functions in vitro, but mechanisms are poorly understood. In this study the authors determined how LAs affect superoxide anion production of hPMNs primed with platelet-activating factor (PAF). The studied which pharmacologic properties important for action and assessed LA site within PAF signaling pathway. Methods Metabolic activity and/or activated were measured using cytochrome-c assay....