A5077291122- Histone Deacetylase Inhibitors Research
- Ubiquitin and proteasome pathways
- RNA Research and Splicing
- RNA modifications and cancer
- Genomics and Chromatin Dynamics
- Cancer, Lipids, and Metabolism
- Peptidase Inhibition and Analysis
- Protein Degradation and Inhibitors
- RNA and protein synthesis mechanisms
- Oral and gingival health research
- Caveolin-1 and cellular processes
- Engineering Applied Research
- Prostate Cancer Treatment and Research
- Cancer-related Molecular Pathways
- Glioma Diagnosis and Treatment
- 3D Shape Modeling and Analysis
- Advanced Breast Cancer Therapies
- Textile materials and evaluations
- Traumatic Brain Injury and Neurovascular Disturbances
- Sulfur Compounds in Biology
- Breast Cancer Treatment Studies
- Pharmacological Effects of Natural Compounds
- Heme Oxygenase-1 and Carbon Monoxide
- Folate and B Vitamins Research
- Cancer, Hypoxia, and Metabolism
China Medical University
2020-2023
Tianjin Medical University
2014-2021
Tianjin First Center Hospital
2014-2021
Growing number of long noncoding RNAs (lncRNAs) are emerging as new modulators in cancer origination and progression. A lncRNA, ADAM metallopeptidase with thrombospondin type 1 motif, 9 (ADAMTS9) antisense RNA 2 (ADAMTS9-AS2), unknown function, is the transcript tumor suppressor ADAMTS9. In present study, we investigated expression pattern functional role ADAMTS9-AS2 glioma by using real-time PCR gain-/loss-of-function studies. The results showed that was significantly downregulated tissues...
Stroke is currently the leading cause of functional impairments worldwide. Folate supplementation inversely associated with risk ischemic stroke. Methylenetetrahydrofolate reductase (MTHFR) an important enzyme involved in folate metabolism. The aim this study to examine whether genetic variants MTHFR gene are stroke and fasting total serum homocysteine (tHcy) level. We genotyped nine tag SNPs a case-control study, including 543 cases 655 healthy controls China. found that subjects rs1801133...
Abstract Hepatocellular carcinoma (HCC) is a common solid tumor with high rate of recurrence and mortality. Anti-angiogenesis drugs have been used for the therapy HCC. However, anti-angiogenic drug resistance commonly occurs during HCC treatment. Thus, identification novel VEGFA regulator would be better understanding progression resistance. Ubiquitin specific protease 22 (USP22) as deubiquitinating enzyme, participates in variety biological processes numerous tumors. While molecular...
Abstract The histone acetyltransferase MOF (KAT8) is mainly involved in the acetylation of H4 at lysine 16 (H4K16) and some non‐histone proteins. expression level significantly reduced many cancers, however biological function its underlying mechanism are still elusive hepatocellular carcinoma (HCC). Estrogen receptor α (ERα) has been considered as a tumor suppressor HCC. Here, we demonstrated that HCC samples, positively correlated with ERα. interacts ERα, participates ERα K266, K268, K299,...
Abstract Androgen receptor (AR) signaling is considered to be crucial for the pathogenesis of hepatocellular carcinoma (HCC) with obvious sexual dimorphism. Pre‐mRNA processing factor 6 (PRPF6) was identified as a coactivator AR. However, molecular mechanism underlying modulation function PRPF6 on AR‐mediated transcriptional activity in HCC needs further clarified. In this study, we analyzed data from The Cancer Genome Atlas show that highly expressed HCC. . Our indicated interacts AR/AR...
USP14 deubiquitinates ERα to maintain its stability in ECEndometrial cancer (EC) is one of the common gynecological malignancies which incidence has been rising for decades. It considered that continuously unopposed estrogen exposure main risk factor EC initiation. Thus, exploring modulation estrogen/estrogen receptor α (ERα) signaling pathway would be helpful well understand mechanism development and find potential target therapy. Ubiquitin-specific peptidase 14 (USP14), a member...
To explore the role and mechanisms of octreotide in neurofunctional recovery traumatic brain injury (TBI) model.Rats were subjected to midline incision followed by TBI prefrontal cortex region. After 72 hours, behavioural neurological deficits tests performed, which included memory testing on Morris water maze for 5 days. Octreotide (15 30 mg/kg i.p.) was administered minutes before subjecting TBI, its administration continued three days.In TBI-subjected rats, restored day 4 escape latency...
Background: Vascular Calcification (VC) is recognized as an independent predictor of cardiovascular events. Estrogen replacement was reported protective treatment against vascular calcification in postmenopausal women, while it controversial because its potential carcinogenicity. ERα co-regulators have been putatively considered therapeutic targets for ERα-related cancers. However, the modulation action and biological function are still elusive.Methods: Quantitative real-time PCR, western...
Abstract Aims: Vascular Calcification (VC) is recognized as an independent predictor of cardiovascular events. Estrogen replacement was reported protective treatment against vascular calcification in postmenopausal women, while it controversial because its potential carcinogenicity. ERα co-regulators have been putatively considered therapeutic targets for ERα-related cancers. However, the modulation action and biological function are still elusive. Methods Results: KDM4B (Histone lysine...
Background : Androgen receptor (AR) signaling is considered to be crucial for the pathogenesis of hepatocellular carcinoma (HCC) with obvious sexual dimorphism, although anti-androgen treatment has no significant effect on HCC therapy. splice variants (AR-Vs) possesses a constitutively active function essential progression. The mechanism underlying modulation AR/AR-V7 action in still elusive. Pre-mRNA processing factor 6 (PRPF6) was identified as coactivator AR. However, what molecular PRPF6...
Endocrine therapy is the common therapeutic strategy for estrogen receptor alpha (ERα)-positive breast cancer, but intrinsic endocrine resistance leads a significant challenge. CTCF as transcription factor essential enhancer-promoter looping to be involved in hyperactivation of ERα-associated enhancers, however, molecular mechanism underlying modulation enhancers still elusive. Here, we have identified BAP18 critical enhancer modulator has global recruitment on gene combining with CTCF....