A5075256683- Parkinson's Disease Mechanisms and Treatments
- Neurological disorders and treatments
- Estrogen and related hormone effects
- Mitochondrial Function and Pathology
- RNA regulation and disease
- Monoclonal and Polyclonal Antibodies Research
- MicroRNA in disease regulation
- Nuclear Receptors and Signaling
- Alzheimer's disease research and treatments
- Prostate Cancer Treatment and Research
- Cancer-related molecular mechanisms research
- Esophageal Cancer Research and Treatment
- Virus-based gene therapy research
- Genetic Neurodegenerative Diseases
- Hepatitis C virus research
- Neurological diseases and metabolism
- Cancer-related Molecular Pathways
- Lung Cancer Diagnosis and Treatment
- Lung Cancer Research Studies
- Hepatitis B Virus Studies
- RNA modifications and cancer
- Influenza Virus Research Studies
- Gastric Cancer Management and Outcomes
- Mycobacterium research and diagnosis
- Ubiquitin and proteasome pathways
Second Xiangya Hospital of Central South University
2016-2025
Central South University
2016-2025
Chengdu University of Traditional Chinese Medicine
2023-2024
Peking University People's Hospital
2024
Peking University
2024
China Medical University
2009-2023
Chinese People's Liberation Army
2021-2023
Chinese PLA General Hospital
2021-2023
Shangqiu First People's Hospital
2019-2022
Fudan University
2017-2021
Abstract Essential tremor is one of the most common movement disorders. Despite its high prevalence and heritability, genetic aetiology essential remains elusive. Up to now, only a few genes/loci have been identified, but these genes not replicated in other families or cohorts. Here we report study cohort 197 Chinese pedigrees clinically diagnosed with tremor. Using comprehensive strategy combining linkage analysis, whole-exome sequencing, long-read whole-genome repeat-primed polymerase...
At autopsy, the time that has elapsed since of death is routinely documented and noted as postmortem interval (PMI). The PMI human tissue samples a parameter often reported in research studies comparable preferred when comparing different populations, i.e., disease versus control patients. In theory, short may alleviate non-experimental protein denaturation, enzyme activity, other chemical changes such pH, which could affect nucleic acid integrity. Previous have compared en masse by looking...
Mitochondria are the organelles responsible for energy metabolism and have a direct impact on neuronal function survival. Mitochondrial abnormalities been well characterized in Alzheimer Disease (AD). It is believed that mitochondrial fragmentation, due to impaired fission fusion balance, likely causes dysfunction underlies many aspects of neurodegenerative changes AD. proteins play major role maintaining health these important organelles. Mitofusion 2 (Mfn2) one such protein regulates which...
Genome-wide association studies (GWASs) have identified numerous susceptibility loci for Parkinson's disease (PD), but its genetic architecture remains underexplored in populations of non-European ancestry. To identify variants associated with PD the Chinese population, we performed a GWAS using whole-genome sequencing (WGS) 1,972 cases and 2,478 controls, replication study total 8209 9454 controls. We one new risk variant rs61204179 (P
Abstract The female predominance for developing Alzheimer disease (AD) suggests the involvement of gender specific factor(s) such as a reduced estrogen-estrogen receptor signaling in pathogenesis AD. potential role ERα AD has been explored by several groups with mixed results. We revisited this issue expression and distribution brain using antibody. Interestingly, we found that co-localized neurofibrillary pathology further demonstrated interacts tau protein vivo . Immunoprecipitaion...
Mediator of DNA damage checkpoint protein 1 (MDC1) is essential for response. However, the role MDC1 in modulating gene transcription independently and underlying mechanisms have not been fully defined. Androgen receptor (AR) central signaling pathway prostate cancer (PCa) its target genes are involved both promotion suppression PCa. Here, we functionally identified as a co-activator AR. We demonstrate that facilitates association between AR histone acetyltransferase GCN5, thereby increasing...
Abstract Background Common and rare variants of guanosine triphosphate cyclohydrolase 1 ( GCH1 ) gene may play important roles in Parkinson’s disease (PD). However, there is a lack comprehensive analysis genotypes, especially non-coding regions. The aim this study was to explore the genetic characteristics , including common coding regions, large population PD patients Chinese mainland, as well phenotypic variant carriers. Methods In first cohort case-control study, we performed whole-exome...
Abstract Background There is a lack of large multicenter Parkinson's disease (PD) cohort studies and limited data on the natural history PD in China. Objectives The objective this study was to launch Chinese Disease Registry (CPDR) report its protocol, cross‐sectional baseline data, prospects for comprehensive observational, longitudinal, study. Methods CPDR recruited patients from 19 clinical sites across China between January 2018 December 2020. Clinical were collected prospectively using...
// Guiling Wang 1 , Yanyan Song Tong Liu Chunyu Qing Zhang Furong Xinze Cai Zhifeng Miao 2 Hongde Xu Huimian Cao Feng Li Department of Cell Biology, Key Laboratory Ministry Public Health, and Medical Education, China University, Shenyang, Surgical Oncology General Surgery, First Hospital Correspondence to: Li, e-mail: fli@mail.cmu.edu.cn Wang, wanggl@mail.cmu.edu.cn Keywords: MORC2, phosphorylation, P21-activated kinase 1(PAK1), gastric cancer Received: November 23, 2014 Accepted: January...
The mechanism of estrogen receptor alpha (ERα)-positive breast cancer-associated bone metastasis is poorly understood. In this article, we report that nuclear p21-activated kinase 4 (nPAK4) a novel repressor ERα-mediated transactivation in 17β-estradiol (E2)-dependent manner and promotes PAK4–ERα axis-mediated by targeting leukemia inhibitory factor (LIFR) ERα-positive cancer. An evaluation clinical cancer samples revealed nPAK4 linked to ERα expression appears be associated with poor...
Depression induces an early onset of Parkinson's disease (PD), aggravates dyskinesia and cognitive impairment, accelerates progression. However, it is very difficult to identify diagnose PD with depression (PDD) in the clinical stage. Few studies have suggested that changes neural networks are associated PDD, while degree centrality (DC) has been documented be effective detecting brain network changes.The objectives this study explore DC between patients PDD without (PDND) find key hubs...
ABSTRACT Background Distinguishing between essential tremor (ET) and tremor‐dominant Parkinson's disease (PD‐TD) can be challenging due to overlapping motor symptoms. This study aims investigate the differences in nonmotor symptoms (NMS) ET PD‐TD patients provide additional evidence for differentiating these two conditions. Methods retrospective included 1656 participants, comprising 558 patients, 584 514 controls. were assessed using Tremor Research Group Essential Rating Assessment Scale...
p21-Activated kinase 1 (Pak1), a serine/threonine kinase, has been implicated in cytoskeletal remodelling, cell motility, apoptosis and transformation. However, the role of Pak1 gastric cancer remains unclear. In this study, we detected expression tissues from 40 patients by western blot. Overexpression was associated with progression, metastasis prognosis cancer. addition, found that knockdown significantly inhibited anchorage-dependent anchorage-independent growth cells, markedly xenograft...
Although previous work has demonstrated that the overexpression of wild‑type or mutant α‑synuclein (α‑syn) can induce cell death via a number different mechanisms, including oxidative stress, dysfunction ubiquitin‑proteasome degradation system, mitochondrial damage and endoplasmic reticulum (ER) research interest primarily focused on neurons. However, there is accumulating evidence suggests astrocytes may be involved in earliest changes, as well progression Parkinson's disease (PD), though...
BPTF associated protein of 18 kDa (BAP18) has been reported as a component MLL1-WDR5 complex. However, BAP18 is an uncharacterized protein. The detailed biological functions and underlying mechanisms have not defined. Androgen receptor (AR), member transcription factor, plays essential role in prostate cancer (PCa) castration-resistant (CRPC) progression. Here, we demonstrate that identified coactivator AR Drosophilar experimental system mammalian cells. facilitates the recruitment MLL1...
Abstract The embryonic developmental toxicity of the ionic liquid (IL) 1‐methyl‐3‐octylimidazolium bromide ([C 8 mim]Br) on goldfish Carassius auratus was evaluated in this study. First, 72 h 50% lethal concentrations (72 h‐LC 50 ) for [C mim]Br embryos at stages cleavage, early gastrula, closure blastopore, and heart beating were determined by preliminary acute tests. After that, fish different (cleavage, beating) exposed to 10.4, 20.8, 41.6, 104 mg/L until their hatching stage. results...