A5086364138- Microtubule and mitosis dynamics
- Genomics and Chromatin Dynamics
- Chromosomal and Genetic Variations
- Ubiquitin and proteasome pathways
- Glycosylation and Glycoproteins Research
- DNA Repair Mechanisms
- Protein Degradation and Inhibitors
- Photosynthetic Processes and Mechanisms
- Carbohydrate Chemistry and Synthesis
- RNA Research and Splicing
- Pluripotent Stem Cells Research
- Genomics and Phylogenetic Studies
- RNA modifications and cancer
- CRISPR and Genetic Engineering
- Epigenetics and DNA Methylation
- Pancreatic function and diabetes
- COVID-19 Clinical Research Studies
- RNA regulation and disease
- Chromatin Remodeling and Cancer
- Galectins and Cancer Biology
- Nuclear Structure and Function
- Developmental Biology and Gene Regulation
- Genetics and Neurodevelopmental Disorders
- Birth, Development, and Health
- Cancer Genomics and Diagnostics
Xiangya Hospital Central South University
2019-2025
Central South University
2017-2025
Yunnan University
2025
Peking University
2025
Peking University Sixth Hospital
2025
Shanxi Agricultural University
2024
National Clinical Research
2020-2024
Precision for Medicine (United States)
2024
Dartmouth College
2023
Laboratoire de Génétique Médicale
2020-2023
Protein O-GlcNAcylation is a post-translational modification coupled to cellular metabolic plasticity. Aberrant has been observed in many cancers including endometrial cancer (EC), common malignancy women. However, clinical characterization of dysregulated homeostasis EC and interrogating its molecular mechanism remain incomplete. Here we report that level positively correlated with histologic grade Chinese cohort containing 219 tumors, validated The Cancer Genome Atlas dataset. Increasing...
Genome-wide association studies (GWASs) have identified numerous susceptibility loci for Parkinson's disease (PD), but its genetic architecture remains underexplored in populations of non-European ancestry. To identify variants associated with PD the Chinese population, we performed a GWAS using whole-genome sequencing (WGS) 1,972 cases and 2,478 controls, replication study total 8209 9454 controls. We one new risk variant rs61204179 (P
Metazoans start embryogenesis with a relatively naïve genome. The transcriptionally inert, late-replicating heterochromatic regions, including the constitutive heterochromatin on repetitive sequences near centromeres and telomeres, need to be re-established during development. To explore events initiating formation examine their temporal control, sequence specificity, immediate regulatory consequence, we established live imaging approach that enabled visualization of steps in emergence...
Drought stress is the primary abiotic factor affecting wheat growth, development, and yield formation. The application of plant growth-promoting rhizobacteria (PGPR) represents an environmentally sustainable approach to mitigate impacts drought on wheat. This study conducted field experiments using two winter varieties, drought-sensitive variety Jimai 22 drought-resistant Chang 6878, aiming investigate effects Streptomyces pactum Act12 inoculation photosynthetic characteristics,...
The Drosophila midblastula transition (MBT), a major event in embryogenesis, remodels and slows the cell cycle. In pre-MBT cycles, all genomic regions replicate simultaneously rapid S phases that alternate with mitosis, skipping gap phases. At MBT, down-regulation of Cdc25 phosphatase resulting inhibitory phosphorylation mitotic kinase Cdk1 create G2 pause interphase 14. However, an earlier change 14 is prolongation phase. While signals modifying phase are unknown, onset late...
Abstract Chromosome segregation in mitosis is orchestrated by the dynamic interactions between kinetochore and spindle microtubules. The microtubule depolymerase mitotic centromere-associated kinesin (MCAK) a key regulator for an accurate kinetochore-microtubule attachment. However, regulatory mechanism underlying precise MCAK activity control during remains elusive. Here, we describe novel pathway involving Aurora B-PLK1 axis regulation of mitosis. B phosphorylates PLK1 on Thr210 to...
Using Hg2+-induced umpolung reaction and aggregation induced emission (AIE), we have rationally developed a water-soluble fluorescent probe 2,2′-(((4-(4,5-bis(4-methoxyphenyl)-1-phenyl-1H-imidazol-2-yl)phenyl)methylene)bis(sulfanediyl))diethanol (MPIPBS) for Hg2+ detection. MPIPBS was found to high selectivity sensitivity toward The mechanism of response verified by 1H NMR titration, HPLC, HRMS spectroscopy. detection limit examined be 1.45 nM, which is lower than most reported probes Hg2+....
Abstract Transposable elements (TEs) through evolutionary exaptation have become an integral part of the human genome, offering ample regulatory sequences and shaping chromatin 3D architecture. While functional impacts TE-derived on early embryogenesis been recognized, their roles in malignancy are only starting to emerge. Here we show that many TEs, especially pluripotency-related endogenous retrovirus H (HERVH), abnormally activated colorectal cancer (CRC) samples. Transcriptional...
Abstract Background There is a lack of large multicenter Parkinson's disease (PD) cohort studies and limited data on the natural history PD in China. Objectives The objective this study was to launch Chinese Disease Registry (CPDR) report its protocol, cross‐sectional baseline data, prospects for comprehensive observational, longitudinal, study. Methods CPDR recruited patients from 19 clinical sites across China between January 2018 December 2020. Clinical were collected prospectively using...
Constitutive heterochromatin, a fundamental feature of eukaryotic nucleus essential for transposon silencing and genome stability, is rebuilt on various types repetitive DNA in the zygotic during early embryogenesis. However, molecular program underlying this process remains poorly understood. Here, we show that histone H3 lysine 14 acetylation (H3K14ac) engaged reinstallation constitutive heterochromatin
Novel near-infrared nanoprobe for detecting GGT in HepG2 cells and imaging liver tumour tissue, satisfying the need clinical measure of level.
O-GlcNAcylation is a dynamic post-translational modification that diversifies the proteome. Its dysregulation associated with neurological disorders impair cognitive function, and yet identification of phenotype-relevant candidate substrates in brain-region specific manner remains unfeasible. By combining an O-GlcNAc binding activity derived from Clostridium perfringens OGA (CpOGA) TurboID proximity labeling Drosophila, we developed profiling tool translates into biotin conjugation for...
Auditory neuropathy spectrum disorder (ANSD) is an auditory dysfunction characterized by impaired speech comprehension. Its etiology complex and can be broadly categorized into genetic non-genetic factors. TMEM43 mutation identified as a causative factor in ANSD. While some studies have been conducted using animal models, its pathogenic mechanisms humans remain unclear. predominantly expressed cochlear glia-like support cells (GLSs) plays vital role gap junction intercellular communication....
Abstract Background In recent years, the number and types of new psychoactive substances have increased. Methcathinone is one most commonly abused substances. Studies shown that methcathinone can cause emotional excitement, paranoid irritability, even lead to violent incidents, posing a threat safety individuals society. Aims & Objectives The purpose this study assess phenotype characteristics risk factors impulsivity aggression among users, further explore role environmental genetic in...
Externally deposited eggs begin development with an immense cytoplasm and a single overwhelmed nucleus. Rapid mitotic cycles restore normality as the ratio of nuclei to (N/C) increases. A threshold N/C has been widely proposed activate zygotic genome transcription onset morphogenesis at mid-blastula transition (MBT). To test whether is required for these events, we blocked increase by down-regulating cyclin/Cdk1 arrest early cell in Drosophila. Embryos that were arrested two prior normal MBT...