A5080511033- Glycosylation and Glycoproteins Research
- Chromosomal and Genetic Variations
- Wound Healing and Treatments
- Neurobiology and Insect Physiology Research
- Galectins and Cancer Biology
- Epigenetics and DNA Methylation
- Acute Myeloid Leukemia Research
- Genomics and Chromatin Dynamics
- Invertebrate Immune Response Mechanisms
- Retinoids in leukemia and cellular processes
- Protein Degradation and Inhibitors
- Dermatologic Treatments and Research
- Ubiquitin and proteasome pathways
- Tissue Engineering and Regenerative Medicine
Central South University
2007-2024
Xiangya Hospital Central South University
2024
Constitutive heterochromatin, a fundamental feature of eukaryotic nucleus essential for transposon silencing and genome stability, is rebuilt on various types repetitive DNA in the zygotic during early embryogenesis. However, molecular program underlying this process remains poorly understood. Here, we show that histone H3 lysine 14 acetylation (H3K14ac) engaged reinstallation constitutive heterochromatin
O-GlcNAcylation is a dynamic post-translational modification that diversifies the proteome. Its dysregulation associated with neurological disorders impair cognitive function, and yet identification of phenotype-relevant candidate substrates in brain-region specific manner remains unfeasible. By combining an O-GlcNAc binding activity derived from Clostridium perfringens OGA (CpOGA) TurboID proximity labeling Drosophila, we developed profiling tool translates into biotin conjugation for...
Abstract The healing of human skin wounds is susceptible to perturbation caused by excessive mechanical stretching, resulting in enlarged scars, hypertrophic or even keloids predisposed individuals. Keloids are fibro‐proliferative scar tissues that extend beyond the initial wound boundary, consisting actively progressing periphery and quiescent center. stretch‐associated outgrowth enhanced angiogenesis two features keloids. However, which cell population responsible for transducing...