A5085563301- Multiple Myeloma Research and Treatments
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Ubiquitin and proteasome pathways
- Signaling Pathways in Disease
- Platelet Disorders and Treatments
- Autophagy in Disease and Therapy
- Genomics and Phylogenetic Studies
- Cancer Genomics and Diagnostics
- Tissue Engineering and Regenerative Medicine
- Peptidase Inhibition and Analysis
- Bone health and treatments
- Wound Healing and Treatments
- Dermatologic Treatments and Research
- Chromosomal and Genetic Variations
- RNA modifications and cancer
- Histone Deacetylase Inhibitors Research
- Phytochemical compounds biological activities
- Mechanisms of cancer metastasis
- Microtubule and mitosis dynamics
- NF-κB Signaling Pathways
- Cancer-related gene regulation
- Protein Degradation and Inhibitors
- Cancer-related molecular mechanisms research
- Toxin Mechanisms and Immunotoxins
- Cytokine Signaling Pathways and Interactions
Xiangya Hospital Central South University
2019-2025
Central South University
2018-2025
Ministry of Education of the People's Republic of China
2023
National Health and Family Planning Commission
2018-2022
Ministry of Health
2020
Sun Yat-sen University
2017-2018
Sun Yat-sen University Cancer Center
2017-2018
State Key Laboratory of Oncology in South China
2018
NEK2 is associated with drug resistance in multiple cancers. Our previous studies indicated that high confers inferior survival myeloma (MM); thus, a better understanding of the mechanisms by which induces MM required. In this study, we discovered enhances cell autophagy, and combination autophagy inhibitor chloroquine (CQ) chemotherapeutic bortezomib (BTZ) significantly prevents NEK2-induced cells. Interestingly, was found to bind stabilize Beclin-1 protein but did not affect its mRNA...
Protein O-GlcNAcylation is a post-translational modification coupled to cellular metabolic plasticity. Aberrant has been observed in many cancers including endometrial cancer (EC), common malignancy women. However, clinical characterization of dysregulated homeostasis EC and interrogating its molecular mechanism remain incomplete. Here we report that level positively correlated with histologic grade Chinese cohort containing 219 tumors, validated The Cancer Genome Atlas dataset. Increasing...
Summary The serine synthesis pathway (SSP) is active in multiple cancers. Previous study has shown that bortezomib (BTZ) resistance associated with an increase the SSP myeloma (MM) cells; however, underlying mechanisms of SSP‐induced BTZ remain unclear. In this study, we found phosphoglycerate dehydrogenase (PHGDH), first rate‐limiting enzyme SSP, was significantly elevated CD138 + cells derived from patients relapsed MM. Moreover, high PHGDH conferred inferior survival We also...
Abstract Thrombocytopenia is a major complication in subset of patients with multiple myeloma (MM). However, little known about its development and significance during MM. Here, we show thrombocytopenia linked to poor prognosis In addition, identify serine, which released from MM cells into the bone marrow microenvironment, as key metabolic factor that suppresses megakaryopoiesis thrombopoiesis. The impact excessive serine on mainly mediated through suppression megakaryocyte (MK)...
Abstract Nasopharyngeal carcinoma (NPC) has the highest rate of metastasis among head and neck cancers, distant is major reason for treatment failure. We have previously shown that high cyclooxygenase‐2 (COX‐2) expression associated with a poor prognosis patients NPC inhibits chemotherapy‐induced senescence in cells. In this study, we found COX‐2 was upregulated cancer‐associated fibroblasts (CAFs) derived from by RNA‐Seq. Furthermore, elevated CAF detected survival using...
Multiple myeloma (MM) is a plasma cell malignancy characterized by clonal proliferation in the bone marrow (BM). Previously, it was reported that G‑protein‑coupled receptor 4 (LGR4) contributed to early hematopoiesis and associated with poor prognosis patients MM. However, mechanism of homing migration, which critical for MM progression, remains unclear. In present study, counting, cycle BrdU assays were performed evaluate proliferation. Transwell assay Xenograft mouse models migration...
Abstract Nasopharyngeal carcinoma (NPC) is a common malignant tumor in southern China and Southeast Asia, but the molecular mechanism of its pathogenesis poorly understood. Our previous work demonstrated that NEK2 overexpressed multiple cancers. However, how involves NPC development remains to be elucidated. In this study, we firstly identified NEK2, located at +1q32‐q33, late event pathogenesis, stage III‐IV paired sequential recurrent patients with by immunohistochemistry. Furthermore,...
Abstract Despite advances in screening and prevention, cervical cancer (CC) remains an unresolved public health issue poses a significant global challenge, particularly for women low-income regions. Human papillomavirus (HPV) infection, especially with the high-risk strains, is primary driver of carcinogenesis. Emerging evidence indicates that integrating HPV testing existing approaches, such as cytology visual inspection, offers enhanced sensitivity specificity CC screening....
Rho guanine nucleotide exchange factors (RhoGEFs) are proteins that activate GTPases in response to extracellular stimuli and regulate various biologic processes. ARHGEF19, one of RhoGEFs, was reported RhoA the Wnt‐PCP pathway controlling convergent extension Xenopus gastrulation. The goal our study identify role molecular mechanisms ARHGEF19 tumorigenesis non‐small cell lung cancer (NSCLC). expression significantly elevated NSCLC tissues, levels were associated with lymph node status,...
Pneumonia accounts for a significant cause of morbidity and mortality in multiple myeloma (MM) patients. It has been previously shown that intestinal Klebsiella pneumonia (K. pneumonia) enriches MM promotes progression. However, what role the altered gut microbiota plays with remains unknown. Here, we show K. is significantly enriched pneumonia. This links to incidence MM, colonization contributes 5TGM1 mice model. Further targeted metabolomic assays reveal elevated level glutamine, which...
Abstract The healing of human skin wounds is susceptible to perturbation caused by excessive mechanical stretching, resulting in enlarged scars, hypertrophic or even keloids predisposed individuals. Keloids are fibro-proliferative scar tissues that extend beyond the initial wound boundary, consisting actively progressing leading edge and quiescent center. stretch-associated outgrowth enhanced angiogenesis two features keloids. However, which cell population responsible for transducing...
Abstract Human endogenous retroviruses (HERVs) compose approximately 8% of the human genome, co-opted into dynamic regulatory network cellular potency in early embryonic development. In recent studies, resurgent HERVs’ transcriptional activity has been frequently observed many types cancers, suggesting their potential functions occurrence and progression malignancy. However, a web resource dedicated to querying relationship between activation HERVs cancer development is lacking. Here, we...
Abstract The healing of human skin wounds is susceptible to perturbation caused by excessive mechanical stretching, resulting in enlarged scars, hypertrophic or even keloids predisposed individuals. Keloids are fibro‐proliferative scar tissues that extend beyond the initial wound boundary, consisting actively progressing periphery and quiescent center. stretch‐associated outgrowth enhanced angiogenesis two features keloids. However, which cell population responsible for transducing...
Multiple myeloma (MM) is a clonal proliferative malignant tumor of plasma cells in bone marrow. With the aging population China, incidence MM on rise. disease (MBD) one common clinical manifestations MM, and 80%-90% patients are accompanied by osteolytic lesions at time their first visit to clinic. MBD not only increases disability rate patients, but also severely reduces physical function due skeletal bone-related events. Currently available drugs for treating ineffective associated with...
Abstract Thrombocytopenia is a major complication in subset of patients with multiple myeloma (MM). However, little known about its development and significance during MM. Here, we show that thrombocytopenia linked to poor prognosis the MM patients. In addition, identify serine, which released from cells into bone marrow microenvironment (BMME), serves as key metabolic factor suppresses megakaryopoiesis thrombopoiesis eventually causes thrombocytopenia. The impact excessive serine on mainly...