A5066273890- Multiple Myeloma Research and Treatments
- RNA modifications and cancer
- Histone Deacetylase Inhibitors Research
- Cancer-related gene regulation
- Platelet Disorders and Treatments
- RNA Interference and Gene Delivery
- RNA Research and Splicing
- Peptidase Inhibition and Analysis
- T-cell and Retrovirus Studies
- Epigenetics and DNA Methylation
- Lymphoma Diagnosis and Treatment
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- Cancer therapeutics and mechanisms
- Autophagy in Disease and Therapy
- CAR-T cell therapy research
- Curcumin's Biomedical Applications
- MicroRNA in disease regulation
- Retinoids in leukemia and cellular processes
- Protein Degradation and Inhibitors
- Chronic Lymphocytic Leukemia Research
- Advanced biosensing and bioanalysis techniques
- Near-Field Optical Microscopy
- Lipid Membrane Structure and Behavior
- Cellular transport and secretion
Central South University
2019-2024
Tianjin Medical University Cancer Institute and Hospital
2016-2022
Tangshan Gongren Hospital
2022
Xiangya Hospital Central South University
2022
National Health and Family Planning Commission
2022
Chinese People's Armed Police Force Medical College Affiliated Hospital
2006
Abstract Metabolites in the tumor microenvironment are a critical factor for progression. However, lack of knowledge about metabolic profile bone marrow (BM) multiple myeloma (MM) limits our understanding MM Here, we show that glycine concentration BM is elevated due to collagen degradation mediated by cell-secreted matrix metallopeptidase 13 (MMP13), while level linked cells utilize channel protein solute carrier family 6 member 9 (SLC6A9) absorb extrinsic subsequently involved synthesis...
Abstract Thrombocytopenia is a major complication in subset of patients with multiple myeloma (MM). However, little known about its development and significance during MM. Here, we show thrombocytopenia linked to poor prognosis In addition, identify serine, which released from MM cells into the bone marrow microenvironment, as key metabolic factor that suppresses megakaryopoiesis thrombopoiesis. The impact excessive serine on mainly mediated through suppression megakaryocyte (MK)...
Abstract It has been previously shown that (never in mitosis gene A)‐related kinase 2 ( NEK2 ) is upregulated multiple myeloma (MM) and contributes to drug resistance. However, the mechanisms behind this upregulation remain poorly understood. In study, it found amplification of hypermethylation distal CpG islands its promoter correlate strongly with increased expression. Patients have a poor rate survival often exhibit TP53 deletion, which an independent prognostic factor MM. This...
Epigenetic modifications contribute to lymphomagenesis. Here, we performed an expression clustering analysis and identified two epigenetic-related clusters (EC1 EC2). EC1 presented abundant TP53, MYD88, HIST1H1D, HIST1H1C, KMT2D EZH2 mutations inferior prognosis. Pathways involved in the regulation of DNA methylation/demethylation, histone methyltransferase activity, protein activity were significantly enriched EC1. However, EC2 was frequently accompanied by B2M, CD70 MEF2B mutations, which...
// Ye Liu 1 , Zhaoyang Wang Di Huang Chao Wu Huihui Li Xin Zhang 2 Bin Meng 3 Zongjin 4 Tianhui Zhu Shuang Yang Wei Sun Laboratory of Molecular Genetics in School Medicine, Nankai University, Tianjin, China Department Histology and Embryology Pathology, Tianjin Medical University Cancer Institute Hospital, Stem cells Correspondence to: Sun, email: sunweibio@nankai.edu.cn Yang, yangshuang@nankai.edu.cn Keywords: LMO2, actin filament, basal-type breast cancer, metastasis, cofilin1 Received:...
Mechanistic target of rapamycin (mTOR) complex 1 is a central integrator nutrient and growth factor inputs that controls cell in eukaryotes. The second generation mTOR kinase inhibitors (TORKi), directly targeting the catalytic site, are more effective than its analogs cancer treatment, particularly inducing apoptosis. However, mechanism underlying cytotoxic effect TORKi remains elusive. Herein, we demonstrate TORKi-induced apoptosis predominantly dependent on loss 1-mediated 4EBP...
To explore the effect of dysregulation epigenetic regulator EZH1 and EZH2 on proliferation in MCL underlying mechanisms.In this study, we elucidated role overexpression by immunohistochemistry correlated them to clinical outcome 41 patients. Quantitative real-time PCR Western blot were applied confirm level well-characterized cell lines which compared those naïve B cells. Then manipulated expression cells using CRISPR/Cas9 system directly investigate their functional roles MCL. We also...
Epigenetics serve a key role in peripheral T cell lymphoma (PTCL). The purpose of the present study was to investigate clinical significance enhancer zeste homolog 2 (EZH2) and histone deacetylase 1 (HDAC1/2) expression PTCL. A total 82 patients were enrolled study, including 43 with PTCL not otherwise specified (PTCL-NOS), 10 angioimmunoblastic T-cell (AITL), 14 natural killer/T-cell (NK/TCL) 15 anaplastic large (ALCL). EZH2 HDAC1/2 detected by immunohistochemistry any correlations between...
Abstract Proteoforms are proteins derived from highly related genes or post translational modifications (PTMs) of the same protein. They share extremely similar primary structures but have varying functions. Unfortunately, protein de novo sequencing including specific PTM/mutation detection is still challenging. Herein, a nanopore‐based technique reported to resolve amino acid order amyloid‐β (Aβ 1‐42 ) with site specificity. Subnanopores sputtered in 5 nm‐thick inorganic membranes sensing...
The role of N6-methyladenosine (m6A) modification in tumor microenvironment has rarely been explored follicular lymphoma (FL). To examine the m6A biological behavior, especially immune landscape FL, we utilized Gene Expression Omnibus database to determine expression signatures m6A-regulators by unsupervised clustering, and then condense into a risk score, which was validated an external cohort from Tianjin Medical University Cancer Institute Hospital. Finally, 16 351 FL patients were...
The molecular heterogeneity of clear cell renal carcinoma (ccRCC) leads to a high mortality the disease, which seriously threatens life patients. Therefore, this study explored functional significance and mechanism microRNA-155-5p nuclear receptor subfamily 3 group C member 2 (NR3C2) in regulation ccRCC.Expression levels NR3C2 mRNA ccRCC cells were analyzed by qRT-PCR, protein expression human was measured Western blot. Biological functions determined through series vitro experiments....
This paper reports a handy technical scheme to decorate atomic force microscopy (AFM) tips toward tip-enhanced Raman spectroscopy (TERS) applications. The major attraction of these homemade lies in that silver decoration can be confined at the apex commercial by means an AFM-controlled electrochemical reaction. reduction Ag+ occurs highly sealed environment secure metal coating efficiency. Key factors include nitrate solution provide Ag+, ambient relative humidity and temperature cell,...
Abstract Thrombocytopenia is a major complication in subset of patients with multiple myeloma (MM). However, little known about its development and significance during MM. Here, we show that thrombocytopenia linked to poor prognosis the MM patients. In addition, identify serine, which released from cells into bone marrow microenvironment (BMME), serves as key metabolic factor suppresses megakaryopoiesis thrombopoiesis eventually causes thrombocytopenia. The impact excessive serine on mainly...