A5001135284- Lymphoma Diagnosis and Treatment
- Chronic Lymphocytic Leukemia Research
- CAR-T cell therapy research
- Acute Lymphoblastic Leukemia research
- Viral-associated cancers and disorders
- Immune Cell Function and Interaction
- PI3K/AKT/mTOR signaling in cancer
- Cancer Immunotherapy and Biomarkers
- CNS Lymphoma Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- T-cell and Retrovirus Studies
- Cutaneous lymphoproliferative disorders research
- Nanoplatforms for cancer theranostics
- Ovarian cancer diagnosis and treatment
- Monoclonal and Polyclonal Antibodies Research
- Cancer Mechanisms and Therapy
- Cancer-related gene regulation
- Multiple and Secondary Primary Cancers
- RNA modifications and cancer
- Gastrointestinal Tumor Research and Treatment
- Cancer Genomics and Diagnostics
- Epigenetics and DNA Methylation
- Galectins and Cancer Biology
- Ferroptosis and cancer prognosis
- Adenosine and Purinergic Signaling
Tianjin Medical University Cancer Institute and Hospital
2016-2025
University of California, San Francisco
2025
Changshu No.1 People's Hospital
2024
National Clinical Research
2018-2024
Institute of Hematology & Blood Diseases Hospital
2022-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2022-2024
Soochow University
2024
Emory University
2019
Tianjin Medical University
2010-2018
Nervous system toxicity (NST) is a frequent and serious adverse event (AE) associated with blinatumomab, the first bispecific antibody drug targeting CD19 CD3. Real-world data are needed to better understand incidence characteristics of NST in clinical practice. Data were obtained from FDA Adverse Event Reporting System (FAERS). The reporting odds ratio (ROR), proportional (PRR), Bayesian confidence interval progressive neural network (BCPNN), multi-item gamma Poisson shrinker (MGPS)...
Abstract Background Triple-negative breast cancer (TNBC) is a highly aggressive malignant disease with high rate of recurrence and metastasis, few effective treatment options poor prognosis. Here, we designed constructed combined photothermal immunotherapy strategy based on cell membrane-coated biomimetic black phosphorus quantum dots (BBPQDs) for tumor-targeted therapy anti-PD-L1 mediated immunotherapy. Results BBPQDs have good conversion efficiency can efficiently target tumor cells...
Background Targeting the PD-1/PD-L1/L2 (programmed cell death protein 1/programmed ligand 1/ligand 2) pathway combined with other immunosuppressive signalings, such as CD73/A2aR (A2a adenosine receptor) signaling, has emerged a promising strategy for cancer treatment. The genetic characteristics of these immune checkpoints need to be further investigated in diffuse large B-cell lymphoma (DLBCL). Methods We performed whole-exome sequencing/targeted deep sequencing investigate and CD73/A2aR....
// Ling Dong 1, * , Huijuan Lv Wei Li 1 Zheng Song Lanfang Shiyong Zhou Lihua Qiu Zhengzi Qian Xianming Liu Lixia Feng Bin Meng 2 Kai Fu 3 Xi Wang 4 Qiang Pan-Hammarström 5 Ping 6 Xianhuo Huilai Zhang Department of Lymphoma, Sino-US Center for Lymphoma and Leukemia, Tianjin Medical University Cancer Institute Hospital, National Clinical Research Cancer, Key Laboratory Prevention Therapy, Tianjin, China Pathology, Pathology Microbiology Internal Medicine, Nebraska Center, Omaha, NE, USA...
Purpose: Although anti-programmed cell death protein 1 antibody (aPD1) immunotherapy and chemotherapy has made much progress in the treatment of melanoma, efficacy still needs to be further improved. Methods: Cancer been greatly enhanced by use nanotechnology. membrane (CCM)-camouflaged nanoparticles have shown promising potential tumor therapy due their excellent homologous-targeting ability, long blood circulation immune escape. This work presents a biocompatible acidic environmental...
Abstract Purpose: To investigate the efficacy and safety of novel orally active PI3Kδ inhibitor in relapsed and/or refractory patients with follicular lymphoma (FL) who had received at least two prior systemic treatments. Patients Methods: Histologically confirmed FL disease progression after receiving second-line or greater therapy were enrolled. Linperlisib was administered 80 mg every day, a 28-day cycle until intolerable toxicity occurred. The primary outcome for study objective response...
Relatively little information is available on quantitative risks of therapy-induced second malignant neoplasm (SMN) in patients with non-Hodgkin lymphoma (NHL). A nested case-control study was conducted a cohort 3412 treated for NHL between 1990 and 2006, including 118 SMN 472 controls. Risks leukemia/lung/breast/colorectal bladder cancer were higher compared the general population. risk leukemia restricted to given cumulative dose cyclophosphamide more than 11 250 mg/m(2). However, no...
Epigenetic modifications contribute to lymphomagenesis. Here, we performed an expression clustering analysis and identified two epigenetic-related clusters (EC1 EC2). EC1 presented abundant TP53, MYD88, HIST1H1D, HIST1H1C, KMT2D EZH2 mutations inferior prognosis. Pathways involved in the regulation of DNA methylation/demethylation, histone methyltransferase activity, protein activity were significantly enriched EC1. However, EC2 was frequently accompanied by B2M, CD70 MEF2B mutations, which...
Abstract Bacterial pathogens rely on their ability to sense and respond environmental stressors survive maintain virulence. The stressosome, a 1.8-megadalton nanomachine, serves as critical sensor regulator of the general stress response. It is composed multiple copies three proteins RsbR, RsbS, kinase RsbT which together orchestrate activation downstream adaptation pathways. Using cryo-electron microscopy, we solved atomic structure five Listeria monocytogenes stressosomes, capturing...
Diffuse large B-cell lymphoma (DLBCL) is a biologically and clinically heterogeneous malignancy. Advances in transcriptomic genetic profiling have significantly enhanced our understanding of the disease's intrinsic pathogenesis, uncovering numerous potential therapeutic targets. However, impact tumor-infiltrating Regulatory T cells (Tregs) on prognosis DLBCL remains controversial. Here, we developed Treg-associated gene signature by integrating single-cell bulk transcriptome data to predict...
ABSTRACT Little is known about the survival benefit of relmacabtagene autoleucel (relma‐cel) in current therapeutic landscape relapsed/refractory (r/r) follicular lymphoma (FL). The study compared outcomes Chinese FL patients administered relma‐cel RELIANCE (NCT04089215) and usual care a retrospective, observational, large‐scale real‐world (RWS). An indirect treatment comparison was carried out for 27 from 53 RWS China. Additionally, direct made with SCHOLAR‐5 study, which assessed available...
The current first-line treatment for peripheral T-cell lymphoma (PTCL) has a typically poor prognosis. Developing new regimen is urgently needed. This phase I study evaluated the maximum tolerated dose (MTD), safety, and efficacy of mitoxantrone hydrochloride liposome (Lipo-MIT) plus cyclophosphamide, vincristine, etoposide, prednisone (COEP) in untreated PTCL. Patients with PTCL were enrolled received Lipo-MIT (15, 18, 20 mg/m 2 ) following 3 + dose-escalation design standard doses COEP...
Transient Receptor Potential channels (TRPs), a class of ion channels, were first described two decades ago. Many TRP family members are major participants in nociception and integration heat pain signals. Recent studies have revealed that subfamilies this channel, such as transient receptor potential vanilloid (TRPV) play important roles breast, ovarian, prostate, pancreatic cancers.We performed comprehensive analysis TRPVs 9125 tumor samples 33 cancer types using multi-omics data extracted...
Novel immune checkpoint blockades, including those targeting CD73 and A2aR, are being evaluated in malignancies clinical trials. Here, we investigated the expression of A2aR as well tumor‐infiltrating lymphocytes (TILs), analyzed their correlations with clinicopathological characteristics survival diffuse large B‐cell lymphoma (DLBCL). We found that on tumor cells, rather than total protein gene levels CD73, was associated survival. Patients + /Pax‐5 (median survival, 57.8 months; 95% CI,...
Follicular lymphoma (FL), the most common indolent lymphoma, is a clinically and genetically heterogeneous disease. However, prognostic value of driver gene mutations copy number alterations has not been systematically assessed. Here, we analysed clinical-biological features 415 FL patients to identify variables associated with disease progression within 24 months first-line therapy (POD24). Patients B symptoms, elevated lactate dehydrogenase β2-microglobulin levels, unfavourable baseline...