A5075020405- CAR-T cell therapy research
- MicroRNA in disease regulation
- Lymphoma Diagnosis and Treatment
- Total Knee Arthroplasty Outcomes
- Blood transfusion and management
- Cancer-related molecular mechanisms research
- Inflammatory mediators and NSAID effects
- Immune Cell Function and Interaction
- Neurological Disease Mechanisms and Treatments
- Cytokine Signaling Pathways and Interactions
- Rheumatoid Arthritis Research and Therapies
- Shoulder Injury and Treatment
- Connective Tissue Growth Factor Research
- Myasthenia Gravis and Thymoma
- TGF-β signaling in diseases
- Sarcoma Diagnosis and Treatment
- Peripheral Neuropathies and Disorders
- Circular RNAs in diseases
- Osteoarthritis Treatment and Mechanisms
- Venous Thromboembolism Diagnosis and Management
- Endometrial and Cervical Cancer Treatments
- Tendon Structure and Treatment
- Phytochemistry and Biological Activities
- CNS Lymphoma Diagnosis and Treatment
- Cancer Mechanisms and Therapy
Tianjin Medical University Cancer Institute and Hospital
2025
Zhejiang Chinese Medical University
2025
Shandong First Medical University
2022
Air Force Medical University
2017-2018
Nervous system toxicity (NST) is a frequent and serious adverse event (AE) associated with blinatumomab, the first bispecific antibody drug targeting CD19 CD3. Real-world data are needed to better understand incidence characteristics of NST in clinical practice. Data were obtained from FDA Adverse Event Reporting System (FAERS). The reporting odds ratio (ROR), proportional (PRR), Bayesian confidence interval progressive neural network (BCPNN), multi-item gamma Poisson shrinker (MGPS)...
Long non-coding RNAs (lncRNAs) may act as oncogenes in small-cell lung cancer (SCLC). Exosomes containing lncRNAs released from cancer-associated fibroblasts (CAF) accelerate tumorigenesis and confer chemoresistance. This study aimed to explore the action mechanism of CAF-derived lncRNA maternally expressed gene 3 (MEG3) on cisplatin (DDP) chemoresistance cell processes SCLC.Quantitative real-time PCR was conducted determine expression levels MEG3, miR-15a-5p, CCNE1. Cell viability...
Diffuse large B-cell lymphoma (DLBCL) is a biologically and clinically heterogeneous malignancy. Advances in transcriptomic genetic profiling have significantly enhanced our understanding of the disease's intrinsic pathogenesis, uncovering numerous potential therapeutic targets. However, impact tumor-infiltrating Regulatory T cells (Tregs) on prognosis DLBCL remains controversial. Here, we developed Treg-associated gene signature by integrating single-cell bulk transcriptome data to predict...
ABSTRACT Little is known about the survival benefit of relmacabtagene autoleucel (relma‐cel) in current therapeutic landscape relapsed/refractory (r/r) follicular lymphoma (FL). The study compared outcomes Chinese FL patients administered relma‐cel RELIANCE (NCT04089215) and usual care a retrospective, observational, large‐scale real‐world (RWS). An indirect treatment comparison was carried out for 27 from 53 RWS China. Additionally, direct made with SCHOLAR‐5 study, which assessed available...
Osteoarthritis (OA) has a high prevalence in female patients and sex may be key factor affecting the progression of OA. The aim present study was to identify genetic signatures synovial membranes with OA elucidate potential associated molecular mechanisms. gene expression profiles GSE55457 GSE55584 datasets were obtained from Gene Expression Omnibus database. Data two normal individuals (GSM1337306 GSM1337310) affected by (GSM1337327 GSM1337330) dataset GSE55457, those three (GSM1339628,...
The beneficial effects of icariin in the management many diseases, such as chronic renal failure and heart failure, are well known. Icariin has also been shown to ameliorate osteoarthritis (OA) symptoms; however, underlying mechanisms remain unclear. In this study, a bioinformatics analysis was performed investigate KEGG pathways icariin-targeted genes involved OA. Our study suggests that plays role OA by regulating inflammatory cytokine production, insulin resistance, cell survival through...
The aim of the current study was to identify gene signatures during early proliferation stage wound repair and effect TGF‑β on fibroblasts reveal their potential mechanisms. expression profiles GSE79621 GSE27165 were obtained from GEO database. Differentially expressed genes (DEGs) identified using Morpheus co‑expressed DEGs selected Venn Diagram. Gene ontology (GO) function Kyoto Encyclopedia Genes Genomes (KEGG) pathway enrichment analysis performed Database for Annotation, Visualization...