A5115595805- Chronic Lymphocytic Leukemia Research
- Lymphoma Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Nausea and vomiting management
- Diet and metabolism studies
- Gastrointestinal Tumor Research and Treatment
- Pathogenesis and Treatment of Hiccups
- Anesthesia and Pain Management
- Cardiac, Anesthesia and Surgical Outcomes
- Anesthesia and Neurotoxicity Research
- Electrocatalysts for Energy Conversion
- Advancements in Battery Materials
- Immunodeficiency and Autoimmune Disorders
- Enhanced Recovery After Surgery
- Barrier Structure and Function Studies
- Cancer Treatment and Pharmacology
- Lung Cancer Research Studies
- Inflammatory Biomarkers in Disease Prognosis
- Salivary Gland Disorders and Functions
- Spinal Hematomas and Complications
- Cancer, Stress, Anesthesia, and Immune Response
- Breast Cancer Treatment Studies
- Pregnancy-related medical research
- COVID-19 and healthcare impacts
- Hip and Femur Fractures
Tianjin Medical University Cancer Institute and Hospital
2014-2025
Beijing Institute of Technology
2024-2025
South China University of Technology
2024-2025
Guangzhou Medical University
2024-2025
Guangzhou First People's Hospital
2024-2025
Jinan University
2025
Shanghai University
2024-2025
Tianjin University of Technology and Education
2024
Peking Union Medical College Hospital
2022-2024
Qingdao University
2024
No therapeutics have yet been proven effective for the treatment of severe illness caused by SARS-CoV-2.We conducted a randomized, controlled, open-label trial involving hospitalized adult patients with confirmed SARS-CoV-2 infection, which causes respiratory Covid-19, and an oxygen saturation (Sao2) 94% or less while they were breathing ambient air ratio partial pressure (Pao2) to fraction inspired (Fio2) than 300 mm Hg. Patients randomly assigned in 1:1 receive either lopinavir-ritonavir...
Nervous system toxicity (NST) is a frequent and serious adverse event (AE) associated with blinatumomab, the first bispecific antibody drug targeting CD19 CD3. Real-world data are needed to better understand incidence characteristics of NST in clinical practice. Data were obtained from FDA Adverse Event Reporting System (FAERS). The reporting odds ratio (ROR), proportional (PRR), Bayesian confidence interval progressive neural network (BCPNN), multi-item gamma Poisson shrinker (MGPS)...
We report the long-term findings and final analysis of a pivotal multicenter trial ibrutinib monotherapy in previously treated patients with Waldenström macroglobulinemia (WM).Sixty-three symptomatic median prior therapies two (range, one to nine therapies), whom 40% were refractory their previous therapy, received at 420 mg/d. Dose reduction was permitted for toxicity.The follow-up 59 months, overall major response rates 90.5% 79.4%, respectively. At best response, serum immunoglobulin M...
Summary Ibrutinib is associated with response rate of 90% and median progression‐free survival (PFS) in excess 5 years Waldenström macroglobulinaemia (WM) patients. CXCR4 mutations are detected 30–40% patients WM associate lower rates shorter PFS to ibrutinib therapy. Both frameshift ( FS ) nonsense NS have been described. The impact these on outcomes not evaluated We studied consecutive a diagnosis WM, therapy, for the presence differences between groups. Of 180 patients, 68 (38%) had...
BCL2 is overexpressed and confers prosurvival signaling in malignant lymphoplasmacytic cells Waldenström macroglobulinemia (WM). Venetoclax a potent antagonist triggers vitro apoptosis of WM cells. The activity venetoclax remains to be clarified.We performed multicenter, prospective phase II study patients with previously treated (NCT02677324). was dose-escalated from 200 mg maximum dose 800 daily for up 2 years.Thirty-two were evaluable, including 16 exposed Bruton tyrosine kinase...
Copper( i ) halides with different polyhedron units were obtained via solvent volatilization, showing consecutive structural evolution and photoluminescence tuning.
Abstract Proteasome inhibition is a standard of care for the primary treatment patients with Waldenström macroglobulinemia (WM). We present long-term follow-up prospective, phase II clinical trial that evaluated combination ixazomib, dexamethasone, and rituximab (IDR) in 26 treatment-naive WM. IDR was administered as 6 monthly induction cycles followed by every-2-month maintenance cycles. The MYD88 L265P mutation detected all patients, CXCR4 mutations were 15 (58%). median time to response...
Tissue-engineered ear cartilage scaffold based on three-dimensional (3D) bioprinting technology presents a new strategy for reconstruction in individuals with microtia. Natural hydrogel is promising material due to its excellent biocompatibility and low immunogenicity. However, insufficient mechanical property required one of the major issues pending be solved. In this study, gelatin methacryloyl (GelMA) reinforced bacterial nanocellulose (BNC) was developed enhance biomechanical properties...
Graphene nanoscrolls (GNSs) are unique structures with interlayer coupling modes distinct from those in graphene and carbon nanotubes, exhibiting potential physical properties yet to be explored. Here we investigated the low-frequency Raman GNSs formed 1 3 layer (1–3LG). The results of spectroscopy show that both shear (C) breathing (LB) have appeared monolayer (1L-GNSs), although these never exist flat 1LG. Remarkably, 2L- 3L-GNSs exhibited multiple linked other numbers, revealing emergence...
Nanozymes, exemplified by metal nanoparticles, have shown promise in the fields of biological diagnostics and therapeutics. However, their practical application is often hindered aggregation or deactivation complex systems. Here, we develop a DNA-engineered nanozyme coating to preserve peroxidase-like catalytic activity platinum nanoparticles environments. We employed thiol-modified single-stranded DNA coat through metal–sulfur interaction. found that negatively charged prevents high-salt...
Patterned assembly of multivalent antibody complexes using DNA nanostructure templates holds the potential for advancing studies cellular signaling and smart theranostic applications. However, evaluating heterogeneity in protein conjugation efficiency at distinct sites on remains challenging. Here, we utilize atomic force microscopy to measure coupling antibodies various positions two-dimensional rectangular origami frameworks single-molecule level, generating spatial maps binding...
Abstract Concurrent Bruton tyrosine kinase and BCL2 inhibition has not yet been investigated in Waldenström macroglobulinemia (WM). We performed an investigator-initiated trial of ibrutinib venetoclax symptomatic treatment-naïve patients with MYD88-mutated WM. Patients received 420 mg once daily (cycle 1), followed by a ramp-up to 400 2). The combination was then administered for 22 additional 4-week cycles. attainment very good partial response (VGPR) the primary end point. Forty-five were...
Abstract It is still a challenge to construct single‐atom level reduction and oxidation sites in single‐component photocatalyst by manipulating coordination configuration for photocatalytic water splitting. Herein, the atomically dispersed asymmetric of six‐coordinated Co‐S 2 O 4 (two exposed S atoms, two OH groups, Co─O─Zn bonds) suspending on ZnIn nanosheets verified combining experimental analysis with theoretical calculation, applied into The site immobilized Vs acts as guide electrons...
To objectively evaluate the road traffic safety levels across different provinces in China, this study investigated spatiotemporal heterogeneity characteristics of macro factors influencing accidents. Panel data from 31 China 2009 to 2021 were collected, and after preprocessing, accident selected as dependent variables. Population size, economic level, motorization highway mileage, unemployment rate, passenger volume explanatory Based on non-stationarity testing data, three models, namely,...