A5101970975- Hepatocellular Carcinoma Treatment and Prognosis
- Health Systems, Economic Evaluations, Quality of Life
- CAR-T cell therapy research
- Liver Disease Diagnosis and Treatment
- Cancer Immunotherapy and Biomarkers
- Gastric Cancer Management and Outcomes
- Pharmaceutical Economics and Policy
- Lipoproteins and Cardiovascular Health
- Cancer, Lipids, and Metabolism
- Helicobacter pylori-related gastroenterology studies
- Medication Adherence and Compliance
- Inflammatory Myopathies and Dermatomyositis
- Cancer Mechanisms and Therapy
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Lung Cancer Research Studies
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Cancer, Hypoxia, and Metabolism
- Hepatitis B Virus Studies
- Pancreatic and Hepatic Oncology Research
- RNA modifications and cancer
- Renal cell carcinoma treatment
- MicroRNA in disease regulation
- Diabetes Management and Research
- Sarcoidosis and Beryllium Toxicity Research
- Lymphoma Diagnosis and Treatment
Sun Yat-sen University
2018-2025
Zhengzhou University
2022-2025
Tianjin Medical University Cancer Institute and Hospital
2020-2025
The First Affiliated Hospital, Sun Yat-sen University
2024-2025
Zhongshan Hospital
2024-2025
Fudan University
2024-2025
Changzhou Third People's Hospital
2025
Theranostics (New Zealand)
2025
Bioanalytica (Switzerland)
2025
First Affiliated Hospital of Zhengzhou University
2024
Nervous system toxicity (NST) is a frequent and serious adverse event (AE) associated with blinatumomab, the first bispecific antibody drug targeting CD19 CD3. Real-world data are needed to better understand incidence characteristics of NST in clinical practice. Data were obtained from FDA Adverse Event Reporting System (FAERS). The reporting odds ratio (ROR), proportional (PRR), Bayesian confidence interval progressive neural network (BCPNN), multi-item gamma Poisson shrinker (MGPS)...
Background Genetic polymorphisms of pri-miR-34b/c and pre-miR-196a2 have been reported to be associated with the susceptibility cancers. However, effect these their interactions hepatitis B virus (HBV) mutations on development hepatocellular carcinoma (HCC) remains largely unknown. We hypothesized that might interact HBV play a role in hepatocarcinogenesis. Methods Pri-miR-34b/c rs4938723 (T>C) rs11614913 were genotyped 3,325 subjects including 1,021 HBV-HCC patients using quantitative PCR....
Disaster is a serious public health issue. Health professionals and community residents are main players in disaster responses but their knowledge levels of medicine not readily available. This study aimed to evaluate training needs among potential responders presented necessity popularize education.A self-reporting questionnaire survey on level was conducted Shanghai, China, 2012. A total randomly selected 547 professionals, 456 medical students, 1,526 local provided intact information. The...
Esophageal squamous cell carcinoma (ESCC) is one of the most common aggressive malignancies worldwide, particularly in northern China. The absence specific early symptoms and biomarkers leads to late-stage diagnosis, while diagnosis risk stratification are crucial for improving overall prognosis. We performed UPLC-MS/MS on 450 ESCC patients 588 controls consisting a discovery group two validation groups identify detection Bioinformatics clinical statistical methods were used profiling...
Dermatomyositis (DM) is an autoimmune disease with a high rate of disability and mortality especially in DM concurrent interstitial lung (DM-ILD). Little known about inflammatory signature heterogeneous endotypes DM. We aimed to illustrate the systemic define ILD-associated endotype. Olink proteomic analysis was performed on serum samples obtained from patients (n = 32), ILD 16), healthy controls 19). Transcriptomic data skin utilized assess immune infiltration investigate correlation...
Synchronous regulation of the photoluminescence and physicochemical characteristics multicolor carbon dots (CDs) can fully realize their application potential in multicomponent imaging. Herein, by utilizing an acid-regulated synthetic strategy, green-emissive orange-emissive CDs that target lipid droplets (LDs) mitochondria (Mito) have been developed for fluorescence visualization LD-Mito interactions. The finding different molecular fluorophores reveals precursor undergoes reaction pathways...
Diffuse large B-cell lymphoma (DLBCL) is a biologically and clinically heterogeneous malignancy. Advances in transcriptomic genetic profiling have significantly enhanced our understanding of the disease's intrinsic pathogenesis, uncovering numerous potential therapeutic targets. However, impact tumor-infiltrating Regulatory T cells (Tregs) on prognosis DLBCL remains controversial. Here, we developed Treg-associated gene signature by integrating single-cell bulk transcriptome data to predict...
Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most prevalent chronic worldwide. However, there a lack of cost-effective and accurate biomarkers to assess degree hepatic steatosis. Estimated small dense low-density lipoprotein cholesterol (EsdLDL-C), calculated value derived from triglyceride (TG) (LDL-C) levels, has emerged as potential indicator. This study aimed explore relationship between EsdLDL-C severity single-center retrospective estimated directly measured...
Periostin (POSTN) expression in cancer cells and circulation has been related to poor prognosis of colorectal carcinoma (CRC). However, the role POSTN expressed intra-tumoral stroma on CRC progression remains largely unknown. This study enrolled 1098 patients who received surgical treatment Shanghai Guangzhou, Mainland China. In cohort, immunohistochemistry score stromal increased consecutively from adjacent mucosa, primary tissues, metastatic tissues (P < 0.001), while medium- high-stromal...
Currently, a significant proportion of cancer patients do not benefit from programmed cell death-1 (PD-1)-targeted therapy. Overcoming drug resistance remains challenge. In this study, single-cell RNA sequencing and bulk data samples collected before after anti-PD-1 therapy were analyzed. Cell-cell interaction analyses performed to determine the differences between pretreatment responders nonresponders relative in changes posttreatment status ultimately investigate specific mechanisms...
Abstract: Hepatoid adenocarcinoma of the lung (HAL) is extremely rare and standardized treatment strategy for HAL has not been established. Patients with unresectable have a shorter survival time ranges from 1 to 36 months. Here, we reported 65-year-old female patient alpha-fetoprotein-producing harboring KRAS -G12V no other targetable driver mutations. The was treated multiple lines chemotherapies followed by PD-1 inhibitor, sintilimab, due positive staining PD-L1, achieved an overall 52...
Gastric cardia adenocarcinoma (GCA) is classified as Siewert type II at the esophagogastric junction in Western countries. The majority of GCA patients do not exhibit early warning symptoms, leading to over 90% diagnoses an advanced stage, resulting a grim prognosis, with less than 20% 5-year survival rate.
Indoleamine 2,3‐dioxygenase 1 ( IDO 1) is a tryptophan‐metabolizing enzyme that widely distributed in normal or malignant tissues and contributes to immunologic tolerance immune escape. However, hepatocellular carcinoma HCC ), the characteristics mechanism of expression have not been well defined. In this study, tumor cells (T‐ was frequently detected (109/112) by immunohistochemistry formalin‐fixed paraffin‐embedded specimens from patients, patterns were mostly focal (102/109). Expression...
Abstract Few single nucleotide polymorphisms (SNPs) associated with the risk of renal cell carcinoma (RCC) have been identified, yet genetic predisposition contributes significantly to this malignancy. We previously showed that follistatin-like 1 (FSTL1) was down-regulated in clear RCC (ccRCC), particular metastatic ccRCC. In present study, we systemically investigated associations 6 SNPs within FSTL1-coding genomic region and postoperative prognosis. Age- gender-matched case-control study...
Aim Insulin-like growth factor-1 receptor (IGF-1R) is one of the main members tyrosine protein kinase family. This binds insulin-like (IGF-1) with a high affinity. IGF-1 member family proteins involved in mediating and development. However, correlations IGF-1R to prognosis tumor-infiltrating lymphocytes different cancers remain unclear. Method research comprehensively analyzed expression pattern influence on clinical significance prediction among 33 types malignancies using The Cancer Genome...
MicroRNA-218 (miR-218) can function as a tumour suppressor and inactivate cancer-promoting inflammation. However, role of miR-218 on hepatocellular carcinoma (HCC) remains unclear. To determine the contribution genetic predisposition its interaction with hepatitis B virus (HBV) mutations to HCC risk. rs11134527 located at putative promoter region pre-miR-218 was genotyped in 1012 healthy controls, 302 surface antigen (HBsAg) seroclearance subjects 2011 chronic HBV infection (1021 HCC) using...
Purpose Quantitative dynamic contrast-enhanced ultrasonography (CEUS) reflects tumor blood perfusion. There are very few studies on the relationship between intrahepatic recurrence of hepatocellular carcinoma (HCC) and We investigated correlation CEUS parameters with after radiofrequency ablation (RFA).Methods This retrospective study enrolled 125 native HCC patients who underwent RFA September 2017 January 2019 curative intent. Pre-ablation quantitative was performed. were extracted from...