A5000398995- Cardiovascular Function and Risk Factors
- Autophagy in Disease and Therapy
- Cancer-related molecular mechanisms research
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Atherosclerosis and Cardiovascular Diseases
- Phagocytosis and Immune Regulation
- Endoplasmic Reticulum Stress and Disease
- Adipokines, Inflammation, and Metabolic Diseases
- Extracellular vesicles in disease
- Metabolism, Diabetes, and Cancer
- MicroRNA in disease regulation
- Osteoarthritis Treatment and Mechanisms
- Diet, Metabolism, and Disease
- Muscle Physiology and Disorders
- Ferroptosis and cancer prognosis
- Adipose Tissue and Metabolism
- Plant Stress Responses and Tolerance
- Cancer Immunotherapy and Biomarkers
- interferon and immune responses
- Inflammatory mediators and NSAID effects
- Ubiquitin and proteasome pathways
- Parathyroid Disorders and Treatments
- Antiplatelet Therapy and Cardiovascular Diseases
- Immune cells in cancer
- Advanced Glycation End Products research
Qilu Hospital of Shandong University
2014-2025
Shanghai Jiao Tong University
2014-2024
Renji Hospital
2014-2024
Guangdong Medical College
2024
Wannan Medical College
2024
Shaoguan University
2024
China Medical University
2015-2023
The Seventh Affiliated Hospital of Sun Yat-sen University
2021-2023
Shandong University
2009-2023
Chinese Academy of Medical Sciences & Peking Union Medical College
1998-2023
Human hepatocellular carcinoma (HCC) is one of the most common cancers worldwide. In this work, we report on a comprehensive characterization gene expression profiles hepatitis B virus-positive HCC through generation large set 5′-read expressed sequence tag (EST) clusters (11,065 in total) from and noncancerous liver samples, which then were applied to cDNA microarray system containing 12,393 genes/ESTs comparison with public database. The commercial microarray, contains 1,176 known genes...
Background/Aims: Adipocyte-derived exosomes (ADEs) stimulate the activation of macrophages and contribute to development insulin resistance. Sonic Hedgehog (Shh) is an exosome-carrying protein stimulates secrete inflammatory cytokines. However, impact ADEs carrying Shh on pro-inflammatory consequently, adipocyte resistance unclear. Methods: 3T3-L1 adipocytes were cultured with high glucose imitate pathogeny isolated from conditioned media via differential ultracentrifugation. We explored...
Trimetazidine, as an anti-ischemic and antioxidant agent, has been demonstrated to have many cardioprotective effects. However, whether early administration of trimetazidine effect on diabetic cardiomyopathy the mechanisms underlying not yet elucidated. We established a type 2 DCM rat model by high-fat diet low-dose streptozotocin. Rats were separated into different groups: control, diabetes, diabetes + (n = 6, each). Cardiac autophagy, cardiac functions, cardiomyocyte apoptosis monitored....
Three hundred cDNAs containing putatively entire open reading frames (ORFs) for previously undefined genes were obtained from CD34+ hematopoietic stem/progenitor cells (HSPCs), based on EST cataloging, clone sequencing, in silico cloning, and rapid amplification of cDNA ends (RACE). The sizes ranged 360 to 3496 bp their ORFs coded peptides 58–752 amino acids. Public database search indicated that 225 exhibited sequence similarities identified across a variety species. Homology analysis led...
Ovarian maturation in crustaceans is temporally orchestrated by two processes: oogenesis and vitellogenesis. The peptide hormone vitellogenesis-inhibiting (VIH), far the most potent negative regulator of crustacean reproduction known, critically modulates ovarian suppressing vitellogenin (VTG) synthesis. In this study, cDNA encoding VIH was cloned from eyestalk Pacific white shrimp, Litopenaeus vannamei, a highly significant commercial culture species. Phylogenetic analysis suggests that L....
Abstract Background Sarcopenia causes several adverse events in elderly people. Muscle fibre atrophy and interstitial fibrosis are the main histopathological changes sarcopenia account for decreased muscle function. Tribbles homologue 3 (TRB3) was previously reported to exhibit age‐related expression play a vital role cell proliferation, differentiation, fibrosis. We aimed investigate how TRB3 affects sarcopenia. Methods Wild‐type knockout C57/BL6J mice were randomly divided into young old...
Abstract To exploit a new collagen resource from the body wall of tropical sea cucumber, pepsin‐solubilized Stichopus monotuberculatus (PSC‐Sm) was isolated and characterized with UV‐vis spectra, sodium dodecyl sulfate‐polyacrylamide gel electrophoresis (SDS‐PAGE), amino acid composition, enzyme‐digested peptide maps, Fourier transform infrared spectroscopy (FTIR), maximum transition temperature ( T m ), solubilities. The absorbance PSC‐Sm exhibited at 218 nm in spectra. triple helical...
Epidermal growth factor-like domain-containing protein 7 (EGFL7) is upregulated in human epithelial tumors and so a potential biomarker for malignancy. Indeed, previous studies have shown that high EGFL7 expression promotes infiltration metastasis of gastric carcinoma. The epithelial–mesenchymal transition (EMT) initiates the metastatic cascade endows cancer cells with invasive migratory capacity; however, it not known if by triggering EMT. We found was overexpressed multiple (GC) cell lines...
Background: Colorectal cancer (CRC) is one of the most common aggressive malignancies. LACTB functions as a tumor suppressor, and previous findings have demonstrated that can inhibit epithelial-to-mesenchymal transition (EMT) proliferation breast CRC cells. However, few studies investigated roles in autophagy CRC. The current study aimed to identify EMT associated with elucidate probable molecular mechanisms through which are involved these processes. Materials Methods: Transwell invasion,...
Abstract Background Yellow-feathered chickens (YFCs) have a long history in China. They are well-known for the nutritional and commercial importance attributable to their yellow color phenotype. Currently, there is huge paucity knowledge of genetic determinants responsible phenotypic biochemical properties these iconic chickens. This study aimed uncover structure molecular underpinnings YFCs trademark coloration. Results The whole-genomes 100 from 10 major traditional breeds Huaibei...
The osteogenic environment promotes vascular calcium phosphate deposition and aggregation of unfolded misfolded proteins, resulting in endoplasmic reticulum (ER) stress chronic renal disease (CKD). Controlling ER through genetic intervention is a promising approach for treating calcification. In this study, we demonstrated positive correlation between stress-induced tribble 3 (TRIB3) expression progression calcification human rodent CKD. Increased TRIB3 promoted smooth muscle cell (VSMC) by...
Abstract Background Exercise rehabilitation is demonstrated to improve the prognosis of patients with coronary heart disease (CHD). Statins, as key medicine lower cholesterol in CHD, result skeletal muscle injury and impair exercise training adaptation. Energy metabolism dysfunction identified potential mechanism underlying statin‐induced injury. In this study, we investigated effects metabolic modulator trimetazidine on energy statin‐associated intolerance. Methods High‐fat fed...
Macrophages can polarize to M2 phenotype decrease inflammation and encourage tissue repair. Nonetheless, its role in sepsis-induced acute lung injury effect on endothelial cells (ECs) regeneration remains unknown. The aim of the current study was explore impact macrophages pulmonary ECs proliferation injury.We co-cultured mouse microvascular (MLMVECs) with following LPS challenge. were intratracheally transplanted into mice subjected cecal ligation puncture (CLP). We further performed...
Currently, a significant proportion of cancer patients do not benefit from programmed cell death-1 (PD-1)-targeted therapy. Overcoming drug resistance remains challenge. In this study, single-cell RNA sequencing and bulk data samples collected before after anti-PD-1 therapy were analyzed. Cell-cell interaction analyses performed to determine the differences between pretreatment responders nonresponders relative in changes posttreatment status ultimately investigate specific mechanisms...
This study used integrated omics technologies to investigate the potential novel pathways and enzymes for 1,4-dioxane degradation by a consortium enriched from activated sludge of domestic wastewater treatment plant. An unclassified genus belonging Xanthobacteraceae increased significantly after magnetic nanoparticle-mediated isolation degraders. Species with relatively higher abundance (> 0.3%) were identified present high metabolic activities in biodegradation process through shotgun...
Serum response factor (SRF) regulates pro-carcinogenic genes in various cancers, but its role oral squamous cell carcinoma (OSCC) remains unclear. SRF expression 70 OSCC samples was detected via immunohistochemistry. Abundant expressed tissues closely associated with tumor metastasis. SRF-overexpressing cells were constructed to evaluate how affects tumorigenesis and epithelial-to-mesenchymal transition (EMT) vitro vivo. Overexpressed increased migration invasion growth This promoted EMT,...
Ferroptosis, which is caused by an iron-dependent accumulation of lipid hydroperoxides, a type cell death linked to diabetic kidney disease (DKD). Previous research has shown that fatty acid binding protein 4 (FABP4) involved in the regulation ferroptosis retinopathy. The present study was constructed explore role FABP4 DKD.We first detected expression and proteins related renal biopsies patients with DKD. Then, we used inhibitor small interfering RNA investigate induced high glucose human...
The use of bioaugmented zeolite (bio-zeolite) can be an effective technology for irreversibly removing recalcitrant organic pollutants in aqueous mixtures. Removal 1,4-dioxane by a bio-zeolite (Pseudonocardia dioxanivorans CB1190-bioaugmented ZSM-5) the presence several chlorinated volatile compounds (CVOCs) was superior to removal adsorption using abiotic zeolite. Mixtures containing 1,1-dichloroethene (1,1-DCE) were exception, which completely inhibited system. Specific characteristics...