A5100401472- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Cancer Mechanisms and Therapy
- Chromatin Remodeling and Cancer
- RNA Research and Splicing
- Genetic Mapping and Diversity in Plants and Animals
- Genetics and Plant Breeding
- Wheat and Barley Genetics and Pathology
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Peptidase Inhibition and Analysis
- Thyroid Cancer Diagnosis and Treatment
- Cancer-related gene regulation
- Plant Molecular Biology Research
- Plant Pathogens and Fungal Diseases
- Photosynthetic Processes and Mechanisms
- interferon and immune responses
- Venous Thromboembolism Diagnosis and Management
- Intensive Care Unit Cognitive Disorders
- Lung Cancer Treatments and Mutations
- Genomics and Phylogenetic Studies
- Anesthesia and Sedative Agents
- Cancer, Hypoxia, and Metabolism
- Anesthesia and Neurotoxicity Research
- Phagocytosis and Immune Regulation
- Ion channel regulation and function
Dalian Municipal Central Hospital
2023-2025
Dalian University of Technology
2023-2025
Southwest Hospital
2020-2025
Army Medical University
2020-2025
Anhui Medical University
2012-2025
He Eye Hospital
2023-2025
Hubei University of Education
2025
Hubei Normal University
2025
China University of Geosciences (Beijing)
2024
Eye & ENT Hospital of Fudan University
2024
N6-methyladenosine (m6A) is an important epitranscriptomic mark with high abundance in the brain. Recently, it has been found to be involved regulation of memory formation and mammalian cortical neurogenesis. However, while now established that m6A methylation occurs a spatially restricted manner, its functions specific brain regions still await elucidation. We identify widespread dynamic RNA developing mouse cerebellum further uncover distinct features continuous temporal-specific across...
The inflammatory response of macrophages has been reported to play a critical role in atherosclerosis. state is modified by epigenetic reprogramming. m6A RNA methylation an modification RNAs. However, little known about the potential roles and underlying mechanisms macrophage inflammation. Herein, we showed that expression "writer" Mettl14 was increased coronary heart disease LPS-stimulated THP-1 cells. Knockdown promoted M2 polarization macrophages, inhibited foam cell formation decreased...
Skeletal muscle stem cells (also known as satellite [SCs]) are essential for regeneration and the regenerative activities of SCs intrinsically governed by gene regulatory mechanisms, but post-transcriptional regulation in remains largely unknown. N(6)-methyladenosine (m6A) modification RNAs is most pervasive highly conserved RNA eukaryotic cells; it exerts powerful impact on almost all aspects mRNA processing that mainly endowed its binding with m6A reader proteins. In this study, we...
Chloroplasts and mitochondria contain their own genomes transcriptional translational systems. Establishing these genetic systems is essential for plant growth development. Here we characterized a mutant form of Val-tRNA synthetase (OsValRS2) from Oryza sativa that targeted to both chloroplasts mitochondria. A single base change in OsValRS2 caused virescent albino phenotypes seedlings white panicles at heading. We therefore named this panicle 1 (wp1). Chlorophyll autofluorescence...
Abstract Background Rhizomatousness is a key component of perenniality many grasses that contribute to competitiveness and invasiveness noxious grass weeds, but can potentially be used develop perennial cereal crops for sustainable farmers in hilly areas tropical Asia. Oryza longistaminata , wild rice with strong rhizomes, has been as the model species genetic molecular dissection rhizome development breeding efforts transfer rhizome-related traits into annual species. In this study, an...
Accumulating evidence has highlighted the potential role of RNA binding proteins (RBPs) in biological behaviors glioblastoma cells. Herein, expression and function FXR1 were investigated human glioma cells.Quantitative real-time PCR conducted to evaluate MIR17HG miR-346, miRNA-425-5p tissues Western blot used explore FXR1, TAL1 DEC1 Stable knockdown cells established Further, RIP pull-down assays investigate correlation between MIR17HG. Cell Counting Kit-8, transwell assays, flow cytometry...
Abstract Background Sarcopenia causes several adverse events in elderly people. Muscle fibre atrophy and interstitial fibrosis are the main histopathological changes sarcopenia account for decreased muscle function. Tribbles homologue 3 (TRB3) was previously reported to exhibit age‐related expression play a vital role cell proliferation, differentiation, fibrosis. We aimed investigate how TRB3 affects sarcopenia. Methods Wild‐type knockout C57/BL6J mice were randomly divided into young old...
Cardiac fibrosis is a leading cause of cardiac dysfunction in patients with diabetes. However, the underlying mechanisms remain unclear. This study aimed to investigate role long non-coding RNA (LncRNA) Airn pathogenesis diabetic cardiomyopathy (DCM) and its mechanism.Diabetes mellitus (DM) was induced mice by streptozotocin injection. An intramyocardial adeno-associated virus (AAV) used manipulate expression. The functional significance DCM were investigated both vitro vivo.Diabetic hearts...
Rationale: Glioma is the most common primary malignant tumor of human central nervous system, and its rich vascular characteristics make anti-angiogenic therapy become a therapeutic hotspot.However, existence glioma VM makes ineffective.SUMOylation post-translational modification that affects cell tumorigenicity by regulating expression activity substrate proteins.Methods: The binding IGF2BP2 SUMO1 were identified using Ni 2+ -NTA agarose bead pull-down assays, CO-IP western blot; in vitro...
Abstract There are wide genomic and phenotypic differences between Asian European pig breeds, yet the current reference genome is Duroc genome. A high‐quality lacking for genetic analysis of agricultural traits in pigs. Here, using a hybrid approach, (MSCAAS v1) Meishan breed assembled with contig N50 size 48.05 Mb. MSCAAS v1 outperforms as breeds. Genomic comparison reveals 49,103 structural variations (SVs) Duroc, 4.02% which Asian‐specific SVs (AP‐SVs). Notably, 30‐Mb hotspot AP‐SVs on...
Abstract Abnormal energy metabolism, including enhanced aerobic glycolysis and lipid synthesis, is a well‐established feature of glioblastoma (GBM) cells. Thus, targeting the cellular glycolipid metabolism can be feasible therapeutic strategy for GBM. This study aimed to evaluate roles MSI2, SNORD12B, ZBTB4 in regulating proliferation GBM MSI2 SNORD12B expression was significantly upregulated low tissues Knockdown or overexpression inhibited cell proliferation. may improve by increasing its...
The blood-tumor barrier (BTB) contributes to poor therapeutic efficacy by limiting drug uptake; therefore, elevating BTB permeability is essential for glioma treatment. Here, we prepared astrocyte microvascular endothelial cells (ECs) and ECs (GECs) as in vitro blood-brain (BBB) models. Upregulation of METTL3 IGF2BP3 GECs increased the stability CPEB2 mRNA through its m6A methylation. bound SRSF5 stability, which promoted ETS1 exon inclusion. P51-ETS1 expression ZO-1, occludin, claudin-5...
Whether there is an association between SWI/SNF genomic alterations in tumors and response to immune checkpoint inhibitors (ICI) remains unclear because prior studies have focused on either individual gene or a predefined set of genes. Herein, using mutational clinical data from 832 ICI-treated patients who underwent whole-exome sequencing, including sequencing all 31 genes the complex, we found that complex were associated with significantly improved overall survival (OS) melanoma,...
Dexmedetomidine plays a pivotal role in mitigating postoperative delirium and cognitive dysfunction while enhancing the overall quality of life among surgical patients. Nevertheless, influence dexmedetomidine on such complications various anaesthesia techniques remains inadequately explored. As such, present study, meta-analysis was conducted to comprehensively evaluate its effects dysfunction.
Retinitis pigmentosa (RP) is a type of inherited retinal degeneration (IRD) that typically leads to vision loss in individuals working age. Currently, over 100 genes and loci, as well 1000 individual variants, have been identified relation RP. The aim this study was investigate the genetic distribution characteristics Chinese patients with RP, describe analyze features high-frequency variant from RPGR gene. A total 69 diagnosed RP 36 families were included study. Blood samples collected, DNA...
Abstract Due to robustness and efficiency, naive Bayes (NB) remains among the top ten data mining algorithms. However, required conditional independence assumption more or less limits its classification performance. Of numerous approaches improving NB, structure extension instance weighting have both achieved remarkable improvements. To make full use of their complementary consensus advantages, this article proposes a hybrid modeling approach combining with weighting. We call resulting model...
The FW2.2-like (FWL) genes encode cysteine-rich proteins with a placenta-specific 8 domain. They play roles in cell division and organ size control, response to rhizobium infection, metal ion homeostasis plants. Here, we target eight rice FWL using the CRISPR/Cas9 system delivered by Agrobacterium-mediated transformation. We successfully generate transgenic T0 lines for 15 of 16 targets. targeted mutations are detected all targets average mutation rate is found be 81.6%. Transfer DNA (T-DNA)...
The ALDH18A1-MYCN positive feedback loop points to a promising therapeutic target in MYCN -amplified neuroblastoma.