A5047392474- Urinary Bladder and Prostate Research
- Erythrocyte Function and Pathophysiology
- Acute Myeloid Leukemia Research
- Advanced Glycation End Products research
- Toxin Mechanisms and Immunotoxins
- Chromatography in Natural Products
- Retinoids in leukemia and cellular processes
- Cell death mechanisms and regulation
- Pharmacological Effects of Natural Compounds
- Multiple and Secondary Primary Cancers
- Aldose Reductase and Taurine
- Ion channel regulation and function
- Amino Acid Enzymes and Metabolism
- Chronic Lymphocytic Leukemia Research
- Cancer Research and Treatments
- Lymphoma Diagnosis and Treatment
- Bladder and Urothelial Cancer Treatments
- Heat shock proteins research
- Colorectal Cancer Surgical Treatments
- Lipid metabolism and disorders
- Trace Elements in Health
- Hemoglobinopathies and Related Disorders
- Iron Metabolism and Disorders
- Traditional Chinese Medicine Analysis
- Caveolin-1 and cellular processes
He University
2025
He Eye Hospital
2025
Second Affiliated Hospital of Nanjing Medical University
2017-2024
Nanjing Medical University
2006-2021
Northwest University
2016-2017
Chongqing Medical University
2017
The Affiliated Yongchuan Hospital of Chongqing Medical University
2017
Ministry of Education of the People's Republic of China
2017
Northwest A&F University
2016
Yangtze University
2015
Few studies assessed effects of individual and multiple ions simultaneously on metabolic outcomes, due to methodological limitation.By combining advanced ionomics mutual information, a quantifying measurement for dependence between two random variables, we investigated associations ion modules/networks with overweight/obesity, syndrome (MetS) type 2 diabetes (T2DM) in 976 middle-aged Chinese men women. Fasting plasma were measured by inductively coupled mass spectroscopy. Significant modules...
Abstract Though cardiovascular diseases (CVDs) and gastrointestinal disorders (GIDs) are different associated with organs, they highly correlated clinically. Importantly, in Traditional Chinese Medicine (TCM), similar treatment strategies have been applied both diseases. However, the etiological mechanisms underlying them remain unclear. Here, an integrated systems pharmacology approach is presented for illustrating molecular correlations between CVDs GIDs. Firstly, we identified pairs of...
BACKGROUND Diverting stoma (DS) is routinely proposed in intersphincteric resection for ultralow rectal cancer, but it associated with increased stoma-related complications and economic burden. Appropriate patient selection operative strategies to avoid formation need further elucidation. AIM To select patients who may not require DS. METHODS This study enrolled 505 consecutive patients, including 84 underwent stoma-free (SF) resection. After matching, were divided into SF (n = 78) DS...
Retinitis pigmentosa (RP) is a type of inherited retinal degeneration (IRD) that typically leads to vision loss in individuals working age. Currently, over 100 genes and loci, as well 1000 individual variants, have been identified relation RP. The aim this study was investigate the genetic distribution characteristics Chinese patients with RP, describe analyze features high-frequency variant from RPGR gene. A total 69 diagnosed RP 36 families were included study. Blood samples collected, DNA...
Dorsal root ganglion (DRG) neurons, which are sensitive to oxidative stress due their anatomical and structural characteristics, play a complex role in the initiation progression of diabetic bladder neuropathy. We investigated hypothesis that antioxidant antiapoptotic effects CGRP may be partly related expression Nrf2 HO-1, via phosphatidylinositol 3-kinase (PI3K)/AKT pathway, thus reducing apoptosis responses. This study shows activates PI3K/AKT thereby inducing increased HO-1 resulting...
We report the genetic analysis of a Chinese family with autosomal dominant non-syndromic progressive sensorineural hearing loss. Taking advantage next-generation high-throughput DNA sequencing technology, we combined whole exome capture Sanger direct sequencing. A novel missense mutation in coagulation factor C homolog (COCH) gene was identified consanguineous family. This seventh exon (c.889G>A; p.C162Y) COCH is most probably disease-causing and it segregates disease. The not found single...
Abstract Neuroinflammation is characterized by the elaborated inflammatory response repertoire of central nervous system tissue. The limitations current treatments for neuroinflammation are well-known side effects in clinical trials monotherapy. Drug combination therapies promising strategies to overcome compensatory mechanisms and off-target effects. However, discovery synergistic drug combinations from herb medicines rare. Encouraged successfully applied cases we move on investigate...
Prostatic cancer (PCa) is a leading cause of related death in males and often regarded as kind androgen-sensitive cancer. Artesunate (ART), semi-synthetic derivative the Chinese herb Artemisia annua, such an anti-cancer agent. However, effects mechanism ART on PCa cells remains unclear. The study aims to elaborate involvement androgen receptor (AR) anti-prostatic artesunate (ART). 22rvl were used vivo vitro, viability apoptosis conducted using...
// Cuiping Yang 1, * , Fei Xiong 2, Jun Dou Xue 3 Xi Zhan 4 Fangfang Shi 5 Miao Li 1 Songyan Wu Shouhua Luo 2 Tianzhu Zhang Yu Ji Ming Ning Gu Department of Pathogenic Biology and Immunology, School Medicine & Collaborative Innovation Center Suzhou NanoScience Technology, Southeast University, Nanjing 210009, China Biological Science Medical Engineering 210096, Hematology, Affiliated First Hospital, 210006, The for Vascular Inflammatory Diseases, Pathology, University Maryland Medicine,...
Background: The present study aimed to use the targeted capture and sequencing technique diagnose adult hereditary spherocytosis (HS). These results were compared with clinical features laboratory examinations explore diagnosis of HS. Methods: Whole blood data from ten patients HS collected. Genomic DNA was extracted, a library prepared. Exomes HS-related genes encoding red cell membrane skeleton protein captured sequenced. Bioinformatics analyses carried out throughout 1000 Genomes Project,...
Objectives The present work evaluated preventive effect of curcumin on cisplatin‐induced bladder cystopathy. Methods Fifteen female rats were divided into (i) Control group administered with physiological saline solution for 5 days; (ii) Cis‐P injected cisplatin (6 mg/kg); and (iii) Cis‐Cur given mg/kg) consecutive days. function was measured by means urodynamic analysis. Furthermore, hematoxylin‐eosin staining Masson trichrome performed morphological cell apoptosis through terminal...
Diabetic cystopathy (DCP) is one of the most common complications diabetes mellitus (DM). A previous study reported that caffeine may improve bladder dysfunction in rats with DM. The aim present was to investigate mechanisms behind capacity for function Sprague Dawley were divided into four groups: control, caffeine, DM and plus treatment (DM + caffeine). Bladder measured by urodynamic analyses. levels nerve growth factor (NGF), brain‑derived neurotrophic (BDNF) calcitonin gene‑related...
Abstract Hereditary spherocytosis (HS) is often misdiagnosed due to lack of specific diagnostic methods. Our study summarized clinical characteristics and described the workflow for mild moderate HS in Chinese individuals, using data from 20 adults, 8 whom presented a familial history HS. We used scanning electron microscopy (SEM) diagnose observed reduced eosin maleimide fluorescence activity (5.50 mean channel (MCF) units) 10 cases HS, which differed significantly when compared with normal...
Abstract Rationale: Anti-glomerular basement membrane disease (anti-GBM disease) is a rare small vessel vasculitis caused by autoantibodies directed against the glomerular and alveolar membranes. Anti-GBM usually monophasic illness relapse after effective treatment. This article reports case of coexistence recurrent anti-GBM T-cell large granular lymphocytic (T-LGL) leukemia. Patient concerns: A 37-year-old man presented with hematuria, edema, acute kidney injury for 2 months. Diagnosis: was...
Aims To examine the protective effects of caffeine in rats with diabetes mellitus (DM) by using urodynamics. Methods Female Sprague‐Dawley ( n = 24) were divided into four groups: control group, DM + (5 mg/kg/day), and (10 mg/kg/day). was induced streptozotocin (STZ). Cystometric studies conducted on all rats. After 8 weeks treatment caffeine, urodynamic parameters, including bladder capacity, residual urine volume, voiding time, peak pressure, measured. Results had a higher capacity...
To study survivin gene expression in APL cells and to explore its correlation with clinical manifestations. PML/RARα mRNA were analysed using RT-PCR. By treatment of ATRA, the NB4 gradually decreased time was almost undetectable 72th hour. Survivin expressed 67% 36 cases (de novo relapse patients) fusion expression. However, 22 remission stage patients without expression, 36%. The positive rate de groups, L-type obviously higher than those period groups significantly lower acute leukemia...
SPLUNC1 (Short palate, lung and nasal epithelium clone1) protein is an abundant secretory product of epithelia present throughout the conducting airways. Although its function still not fully known, most studies have focused on defensive effect in infection human airways potential to serve as a molecular marker for cancer. In this study, we further evaluated expression patients with disease explore role cancer or tuberculosis at level. We generated panel antibodies by using from eukaryotic...