A5100359984- Cancer-related molecular mechanisms research
- Advanced biosensing and bioanalysis techniques
- Cervical Cancer and HPV Research
- RNA modifications and cancer
- Monoclonal and Polyclonal Antibodies Research
- RNA Interference and Gene Delivery
- Virus-based gene therapy research
- RNA Research and Splicing
- AI in cancer detection
- MicroRNA in disease regulation
- Lymphoma Diagnosis and Treatment
- Signaling Pathways in Disease
- Colorectal Cancer Screening and Detection
- Cell Adhesion Molecules Research
- Immune Cell Function and Interaction
- Rheumatoid Arthritis Research and Therapies
- Heat shock proteins research
- Cerebrovascular and genetic disorders
- Circular RNAs in diseases
- Ecology and Vegetation Dynamics Studies
- Phagocytosis and Immune Regulation
- vaccines and immunoinformatics approaches
- Moyamoya disease diagnosis and treatment
- PI3K/AKT/mTOR signaling in cancer
- Animal Genetics and Reproduction
Jilin Province Tumor Hospital
2025
Southeast University
2014-2023
Shandong First Medical University
2022
Shandong Provincial QianFoShan Hospital
2018-2021
Shandong University
2018-2021
Sun Yat-sen University
2021
Hangzhou Dianzi University
2020-2021
Harbin Medical University
2020
Second Affiliated Hospital of Harbin Medical University
2020
Nanjing University
2006-2020
Human intestinal microbes can mediate development of arthritis - Studies indicate that certain bacterial nucleic acids may exist in synovial fluid (SF) and could be involved arthritis, although the underlying mechanism remains unclear. To characterize potential SF acids, we used 16S rRNA gene amplicon sequencing to assess acid communities 15 tissue (ST) 110 samples from 125 patients with rheumatoid (RA) 16 ST 42 58 osteoarthritis (OA). Our results showed an abundant diversity these clinical...
Bacterial antitumor therapy has great application potential given its unique characteristics, including genetic manipulation, tumor targeting specificity and immune system modulation. However, the nonnegligible side effects limited efficacy of clinical treatment limit their biomedical applications. Engineered bacteria for therapeutic applications ideally need to avoid accumulation in normal organs possess potent activity. Here, we show that macrophage-mediated tumor-targeted delivery...
Abstract The long noncoding RNA antisense in the INK4 locus (ANRIL) plays a critical role development of atherosclerosis. However, precise effect ANRIL on endothelial dysfunction remains unclear. In this study, we investigated expression patients with coronary artery disease and elucidated molecular mechanism underlying its effect. was detected blood plasma 111 patients. We analysed correlation between markers. also examined regulation dysfunction. levels were increased acute syndrome. is...
Innate DNA repair mechanisms play a critical role in protecting skin keratinocytes from UV mutagenesis and cancer development. We hypothesized that individuals who develop frequent cancers may harbor germline defects genes have increased predisposition to internal malignancies. enrolled 61 patients with unusually basal cell carcinoma (BCC) development, seen at Stanford Hospital Clinics January 2005 until December 2015, for analysis of 29 genes. In parallel, case-control retrospective review...
Abstract Aim Long noncoding RNAs (lncRNAs) are key mediators with a wide range of pathophysiological functions, but their role in human hepatocellular carcinoma (HCC) is still unclear. Methods An unbiased microarray study evaluated novel lncRNA, HClnc1, that linked to the development HCC. In vitro cell proliferation assays and an vivo xenotransplanted HCC tumor model were performed determine its followed by antisense oligo‐coupled mass spectrometry identify HClnc1‐interacting proteins. To...
Metastasis-associated lung adenocarcinoma transcript 1 (malat1) is an oncogenic long non-coding RNA (lncRNA) which has been proven to be associated with various types of tumors. Transcription factor specificity protein (SP1) overexpressed in many cancers. Previously, we observed that malat1 expression level regulated by SP1 cancer. In the present study, found transfection construct 5' end fragment M5 enhances stability and transcriptional activity SP1. Various target genes are also...
Objective The contribution of activating transcription factor 6α (ATF6α) in rheumatoid arthritis (RA) pathogenesis, especially on fibroblast-like synoviocytes (FLSs), has been suggested by its sensitivity to inflammatory stimulus. However, the exact role and therapeutic potential ATF6α RA remains be fully elucidated. Methods expression was determined joint tissues FLS, gain-of-function loss-of-function analyses were applied evaluate biological roles FLSs. A murine collagen-induced (CIA)...
Polyethylenimine (PEI) has been known as an efficient gene carrier with the highest cationic charge potential. High transfection efficiency of PEI, along its cytotoxicity, strongly depends on molecular weight. To enhance delivery and minimize we have synthesized small cross-linked PEI biodegradable linkages evaluated their efficiencies in vitro. In this study, branched a weight 800 Da was by diacrylate [1,4-butanediol or ethyleneglycol dimethacrylate (EGDMA)] for 2-6 h. The vitro plasmid DNA...
High-risk human papillomavirus (HPV) infection was one of the first step in process carcinogenesis cervical cancers. The expression viral oncoprotein E7 essential this by inactivating tumor suppressor proteins RB, addition to interacting with other host proteins. LncRNA MALAT1 found be altered cancer tissues, suggesting an important role tumorigenesis. Moreover, also overexpressed HPV16 positive cell lines dependent manner. To explore mechanism involved up-regulation, deletion mutant E7∆N...
In this study, a releasable disulfide carbonate linker is used to prepare disulfide-containing crosslinked polyethyleneimines (PEI-SS-CLs) for gene delivery. ESI-MS analysis shows that after being incubated with 1,4-dithio-DL-threitol (DTT), the degradable linkages in polyethyleneimine (PEI) derivatives undergo bond cleavage followed by intramolecular cyclization and of neighboring carbamate bond. Moreover, it observed thiol/polyanions trigger release DNA from polyplexes via reductive...
PAX5, a member of the paired box gene family transcription factors, is B-cell-specific activator protein that plays important roles during B lymphopoiesis. Two putative PAX5 binding sites in human GINS1 promoter region were identified. EMSA, ChIP and luciferase assay showed functions as positive factor for expression. Furthermore, coordinated expression was observed mice cells under physiological conditions LPS stimulation situations. A similar pattern also DLBCL cell lines...
P66Shc is partially localised within the mitochondrial fraction. It primarily related to generation of reactive oxygen species and apoptosis. Based on previous studies, we hypothesize that in retina, p66Shc may exist affect development diabetic retinopathy. The purpose this study was investigate expression retinal streptozotocin-induced (SD) rats, which provide a pathway pathogenesis retinopathy.Reverse transcription-polymerase chain reaction (RT-PCR) western blot were used detect mRNA...