A5000610407- Kruppel-like factors research
- Cancer-related gene regulation
- Epigenetics and DNA Methylation
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- RNA modifications and cancer
- Peptidase Inhibition and Analysis
- Cancer-related molecular mechanisms research
- Crystallization and Solubility Studies
- Cancer Mechanisms and Therapy
- X-ray Diffraction in Crystallography
- Ovarian cancer diagnosis and treatment
- Bladder and Urothelial Cancer Treatments
- Genetic factors in colorectal cancer
- Urinary and Genital Oncology Studies
- Liquid Crystal Research Advancements
- Cell Adhesion Molecules Research
- Helicobacter pylori-related gastroenterology studies
- MicroRNA in disease regulation
- Cancer Cells and Metastasis
- Genetic Syndromes and Imprinting
- Transplantation: Methods and Outcomes
- Advanced Optical Imaging Technologies
- Molecular Biology Techniques and Applications
- Neuroendocrine Tumor Research Advances
- Medical Imaging and Pathology Studies
Nankai University
2025
Nanjing Medical University
2014-2023
Soochow University
2023
University of Science and Technology Beijing
2023
C-Com Satellite Systems (Canada)
2023
Nanjing University
2005-2015
Nanjing Maternity and Child Health Care Hospital
2015
Pudong New Area People's Hospital
2015
Indiana University – Purdue University Indianapolis
2013
Indiana University School of Medicine
2013
Renal cell carcinoma (RCC) associated with Xp11.2 translocation is uncommon, characterized by several different translocations involving the TFE3 gene. We assessed utility of break-apart fluorescence in situ hybridization (FISH) establishing diagnosis for suspected or unclassified cases negative equivocal immunostaining analyzing 24 renal cancers FISH and comparing molecular findings results cathepsin K same tumors. Ten tumors were originally diagnosed as RCC on basis positive...
(−)-Epigallocatechin gallate (EGCG) and curcumin are two naturally derived agents that have been widely investigated worldwide. They exhibit their anti-tumor effects in many types of cancers. In the current study, effect combination on non-small cell lung cancer (NSCLC) cells was investigated. The results revealed at low concentrations, EGCG strongly enhanced cycle arrest. Flow cytometry analysis showed were arrested G1 S/G2 phases. Two main related proteins cyclin D1 B1 significantly...
Abstract The present study elucidates the potential role of Trop2 in tumor invasion and promotion epithelial‐mesenchymal transition (EMT) when binding β‐catenin GC. promoting EMT GC cells was examined by a variety experimental assays. Moreover, underlying molecular mechanism studied vivo vitro expression relation to metastasis status detected IHC 248 cases tissues 86 matched adjacent tissues. promoted induces Meanwhile, elevated protein levels mesenchymal markers were also found...
Background: CD10 is a cell surface metalloproteinase expressed by variety of normal types, including lymphoid precursor cells, germinal center B lymphocytes and some epithelial cells. Although accumulating data indicate that expression stromal cells involved in colorectal carcinogenesis it novel prognostic factor breast carcinoma, CD10-positive their correlation with invasion metastasis have not been studied gastric carcinoma. The aim this study was to immunohistochemically investigate the...
Proteolysis targeting chimera (PROTAC) is emerging as a promising medicinal modality, which has aroused widespread interest among the field of pharmaceutical manufacturing in recent years. ARV-471 an orally active PROTAC estrogen receptor degrader against breast cancer, leads to ubiquitylation and subsequent degradation receptors via proteasome. In this study, we developed highly sensitive liquid chromatography tandem mass spectrometry method (LLOQ = 0.5 ng/mL) for measurement rat plasma....
Abstract The conversion of flue gas CO 2 into high‐value chemicals via multicomponent reactions (MCRs) offers the advantages atom economy, bond‐formation efficiency and product complexity. However, because competition between reaction sequences pathways among substrates, efficient synthesize desired is a great challenge. Herein, porous noble‐metal‐free framework ( Cu‐TCA) was synthesized, which can highly effectively catalyze by modulating pathways. pores with size 6.5 Å×6.5 Å in Cu‐TCA...
Abstract Sulfonylurea receptor 1 (SUR1) is the regulatory subunit of ATP-sensitive potassium channels (KATP channels) and antidiabetic drugs, such as glibenclamide, which induce insulin secretion in pancreatic β cells. However, expression role SUR1 cancer are unknown. In this study, we found that was elevated human non–small cell lung carcinoma (NSCLC) tissues lines. silencing suppressed growth NSCLC cells, while overexpression promoted growth. Targeting with glibenclamide growth, cell-cycle...
Reactive stromal changes in prostate cancer (PCa) are likely involved the emergence of castration-resistant PCa (CRPC). This study was designed to investigate patients with clinically advanced and analyze their prognostic significance. Prostate needle biopsies obtained from 148 before castration therapy were analyzed by Masson trichrome staining immunohistochemical analysis vimentin desmin. stroma grading inversely correlated Gleason score. Stroma grade (Masson stain 82.8% vs 45.6%, P <...
The purpose of this study was to investigate the expression HNF-1β in various types epithelial ovarian cancers and discuss its utilization diagnosis clear cell carcinoma (OCCC). This designed detect proteins 27 OCCCs, 35 high-grade serous carcinomas, 21 endometrioid adenocarcinomas, 10 mucinous 2 transitional 13 metastatic Krukenberg tumors by EnVision immunohistochemical system. Twenty-three (85.2%) OCCCs showed diffuse moderate strong nuclear staining for HNF-1β. In cancers, detected 1...
Abstract Gastric cancer is the third leading cause of cancer‐related deaths worldwide, and patients with lymph node, peritoneal distant metastasis have a poor prognosis. Overexpression Astrocyte‐elevated gene‐1 (AEG‐1) has been reported to be correlated progression gastric cancer. However, its mechanisms are quite unclear. In this study, we found that elevated expression AEG ‐1 was in human tissues. Moreover, gain‐ or loss‐of‐function ‐1, respectively, promoted suppressed...
BACKGROUND The relevance of c-Met expression as a prognostic or predictive clinical indicator in chemotherapy-resistant breast cancer remains unknown. aims this study were to investigate the tissues and its association with type II topoisomerase (TOPO II), including patients who received neoadjuvant chemotherapy (NAC), resistance vitro cell lines. MATERIAL AND METHODS Tissue samples from 255 cancer, matched adjacent normal tissue, used tissue microarrays (TMAs). protein levels determined...
Metanephric adenoma is a rare, benign renal neoplasm with occasional misdiagnosis. However, its molecular characterization not fully understood.In this study, we use the hybrid capture-based Next-Generation Sequencing to sequence panel of 295 well-established oncogene or tumor suppressor genes in 28 cases MA patients China. Novel clinicopathological markers associated mitogen-activated protein kinase (MAPK) pathway metanephric were detected by immunohistochemistry.It was found that except...
High frequency of MNNG HOS transforming (MET) exon 14 skipping mutation (MET 14Δ) has been reported in pulmonary sarcomatoid carcinomas (PSCs). However, the frequencies differ greatly. Our study aims to investigate MET alterations and correlations among 14Δ, amplification, protein overexpression a large cohort PSCs. were detected 124 surgically resected PSCs by using Sanger sequencing, fluorescent situ hybridization (FISH), immunohistochemistry (IHC) respectively. 14Δ was identified 9 (7.3%)...
Abstract Background Early lung cancer detection remains a clinical challenge for standard diagnostic biopsies due to insufficient tumor morphological evidence. As epigenetic alterations precede changes, expression of certain imprinted genes could serve as actionable biomarkers malignant lesions. Results Using the previously established quantitative chromogenic gene in situ hybridization (QCIGISH) method, elevated aberrant allelic GNAS , GRB10 SNRPN and HM13 was observed cancers over benign...