A5101968260- Medical Imaging and Pathology Studies
- Metastasis and carcinoma case studies
- Phytochemical compounds biological activities
- Peptidase Inhibition and Analysis
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Dementia and Cognitive Impairment Research
- Lung Cancer Treatments and Mutations
- Maternal Mental Health During Pregnancy and Postpartum
- Colorectal Cancer Treatments and Studies
- CAR-T cell therapy research
- Cancer Research and Treatments
- Polyomavirus and related diseases
- Intensive Care Unit Cognitive Disorders
- Health disparities and outcomes
- Cancer Cells and Metastasis
- Cancer-related gene regulation
- Genomics, phytochemicals, and oxidative stress
- Cancer Mechanisms and Therapy
- Tuberous Sclerosis Complex Research
- Fungal Biology and Applications
- Sleep and related disorders
- Stress Responses and Cortisol
- Blood Pressure and Hypertension Studies
- Kruppel-like factors research
- Paraquat toxicity studies and treatments
Shaoxing Second Hospital
2025
Southeast University
2021-2023
Nanjing Medical University
2019-2021
Linyi People's Hospital
2020
Zhongda Hospital Southeast University
2020
To identify and evaluate risk factors for psychiatric disorders in pediatric patients with tuberous sclerosis complex (TSC).We recruited 121 children TSC from the Hangzhou Children's Hospital between April 2021 December 2023. Four clinical scales were used to screen diagnose comorbidities of TSC: autism behavior checklist, SNAP-IV scale, self-rating anxiety depression scales. Risk related each disorder analyzed using univariate multivariate regression analyses.Comorbid found 70 (57.85%)...
Abstract Sulfonylurea receptor 1 (SUR1) is the regulatory subunit of ATP-sensitive potassium channels (KATP channels) and antidiabetic drugs, such as glibenclamide, which induce insulin secretion in pancreatic β cells. However, expression role SUR1 cancer are unknown. In this study, we found that was elevated human non–small cell lung carcinoma (NSCLC) tissues lines. silencing suppressed growth NSCLC cells, while overexpression promoted growth. Targeting with glibenclamide growth, cell-cycle...
Abstract The aim of this study is to examine the effect cordyceps acid (CA) on lung cancer in mice. A animal model was established by inoculating cells under armpit nude mental state, body weight, and tumor growth mice were recorded detail. levels Nrf‐2/HO‐1/NLRP3/NF‐κB pathway apoptosis tissues detected Western blot analysis immunohistochemical methods. Our results show that CA inhibited regulating signal. In summary, has an obvious inhibiting via regulation
Lung cancer is the leading cause of cancer-related deaths. EGFR tyrosine kinase inhibitors, such as erlotinib, were approved for non-small cell lung carcinoma patients with mutations. However, acquired resistance these inhibitors has not been fully clarified. Therefore, clarifying mechanism and developing new rationales to overcome drug are urgently needed.A pair erlotinib sensitive resistant cells was used identify key molecules in mediating resistance. Loss- or gain-of-function study...
Circulating cancer cells (CTCs) can serve as a non-invasive liquid biopsy and provide opportunities for early diagnosis evaluation. However, the value of CTCs or prognosis small pulmonary nodules (SPNs) is unclear. Fifty-three patients diagnosed with SPNs diameter less than 30 mm by CT examination were enrolled in study. The CTC numbers, features, serum tumor marker concentrations, histopathological characteristics analyzed. Centromere probe 8 (CEP8) was used identification. numbers...
Background: AEG-1 has been proven to be tumor enhancer in gastric cancer. However, its mechanism not yet fully clarified. Methods: Gain-of-function and loss-of-function experiments were conducted determine the role of eIF4E AEG-1-induced growth cancer cells xenografts a nude mouse model. Western blot analysis SRB assay used protein expression levels survival cell numbers. Results: Silencing inhibited parallel with decreased cyclin D1 expression; however, overexpression promoted increased...
Background: To investigate the characterizations of CT (computed tomography) and MRI (magnetic resonance imaging) in patients with carotid atherosclerosis. Methods: A retrospective analysis was performed on medical records 264 atherosclerosis underwent Linyi Central Hospital, Linyi, China from January 2010 to 2016. Among them, 142 ischemic stroke were experimental group (test group), another 122 control group. The lumen stenosis degree, plaque fibrous cap status, calcification information...
Abstract Background Circulating cancer cells (CTCs) provide opportunities for early diagnosis and evaluation of stage as a more acceptable non-invasive liquid biopsy. The advanced development use CTCs or prognosis just started in recent years. Methods Fifty three patients, diagnosed SPNs with diameter less than 30 mm by CT examination, was enrolled statistical analysis based on their level, examination features, serum tumor marker concentrations, histopathological characteristics. Centromere...
Abstract Background: Circulating cancer cells (CTCs) provide opportunities for early diagnosis and evaluation of stage as a more acceptable non-invasive liquid biopsy. The advanced development use CTCs or prognosis just started in recent years. Methods: Fifty three patients, diagnosed SPNs with diameter less than 30 mm by CT examination, was enrolled statistical analysis based on their level, examination features, serum tumor marker concentrations, histopathological characteristics....
Abstract Anti-tumor immune therapy has achieved great success. Antibody drugs targeting PD1/PD-L1 have brought significant benefits for cancer patients. In the post-PD1/PD-L1 era, many novel targets tumor-related modulation been discovered, and tremendous efforts put to develop new biologics these targets. There is an urgent need a high-throughput functional system that mimics tumor microenvironment screen antibodies. Equipped with expertise in immunology cell biology, KYinno generated panel...