A5032720687- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- RNA modifications and cancer
- RNA Research and Splicing
- Monoclonal and Polyclonal Antibodies Research
- Cell Adhesion Molecules Research
- Cancer-related gene regulation
- Protease and Inhibitor Mechanisms
- Cerebrovascular and genetic disorders
- Bacteriophages and microbial interactions
- Metalloenzymes and iron-sulfur proteins
- Circular RNAs in diseases
- Advanced biosensing and bioanalysis techniques
- Bioactive natural compounds
- GABA and Rice Research
- Cancer-related Molecular Pathways
- Peptidase Inhibition and Analysis
- Cancer Cells and Metastasis
- vaccines and immunoinformatics approaches
- Cancer Research and Treatments
- Esophageal Cancer Research and Treatment
- Biosensors and Analytical Detection
- Biochemical effects in animals
- Autophagy in Disease and Therapy
- Cancer, Hypoxia, and Metabolism
Nanjing Drum Tower Hospital
2015-2022
Nanjing Medical University
2020
Nanjing University
2014
Although many of the recently approved genomically targeted therapies have improved outcomes for patients in non–small-cell lung cancer (NSCLC) with adenocarcinoma, little is known about genomic alterations that drive squamous cell (SCC) and development effective SCC a promising area to be further investigated. Discoidin domain receptor 2 (DDR2), novel tyrosine kinases respond several collagens involved tissue repair, primary metastatic progression. Expression DDR2 mRNA was analyzed 54...
Changes in expression of long non-coding RNAs (lncRNAs) plasma exosomes can be useful for diagnosis cancer patients. Here, we conducted a four-stage study to identify exosome lncRNAs with diagnostic potential esophageal squamous cell carcinoma (ESCC). First, lncRNA profiles were examined ESCC patients, esophagitis and healthy controls using RNA sequencing. Differentially expressed from the profile then evaluated by qRT-PCR large cohort controls. Expression levels NR_039819, NR_036133,...
Background: MicroRNAs (miRNAs) have been demonstrated to play crucial roles in the initiation and development of non-small cell lung cancer (NSCLC). However, further investigation specific role miR-126 NSCLC is still required. Methods: An analysis expression was carried out using Gene Expression Omnibus (GEO) database, a literature review also performed. The differentially expressed genes (DEGs) three mRNA datasets, GSE18842, GSE19804, GSE101929, from GEO were identified. Following...
α1-antitrypsin (AAT) has been recognized to be associated with lung adenocarcinoma metastasis. However, the mechanisms by which AAT promotes tumor metastasis remain investigated. Herein, we first examined expression in a panel of formalin-fixed paraffin-embedded tissues from 88 patients undergoing curative resection, using immunohistochemical methods. Lung high showed significantly shorter overall survival compared those low Kaplan-Meier method (P=0.008). High was also identified as an...
Metastasis-associated lung adenocarcinoma transcript 1 (malat1) is an oncogenic long non-coding RNA (lncRNA) which has been proven to be associated with various types of tumors. Transcription factor specificity protein (SP1) overexpressed in many cancers. Previously, we observed that malat1 expression level regulated by SP1 cancer. In the present study, found transfection construct 5' end fragment M5 enhances stability and transcriptional activity SP1. Various target genes are also...
The resistance of non-small cell lung cancer cells to cisplant is a common clinical phenomenon which could induce poor therapeutic effect and should be difficult problem solved. SIRT1 Noxa expression are associated with the chemotherapy for tumors. present study focused on how influence senstivity dissected potential mechanism involved Noxa.The difference between A549 A549/DDP was detected by real-time quantitative PCR (qRT-PCR) Western blot. targeted siRNA uesed inhibit in A549/DDP, after...
Four and a half Lin-11, Isl-1, Mac-3 (LIM) protein 1 (FHL1) is one of the FHL family, which regarded as tumor suppressor in multiple malignant tumors. In this study, we aimed to explore regulatory effects mechanisms FHL1 on lung cancer cell invasion.In experimental bioinformatics analysis transcripts human adenocarcinomas TCGA database was performed. Quantitative real-time polymerase chain reaction (PCR) performed detect mRNA expression 15 paired tissues their adjacent normal tissues, or...
Lung cancer is the leading cause of cancer-related death worldwide. Overall survival all stages unsatisfactory due to high metastasis and recurrence rates. Recent studies indicated that epithelial-to-mesenchymal transition (EMT) involved in progression cancer. Some reports also indicate HS3ST3B1 angiogenesis proliferation cells. However, its role non-small cell lung (NSCLC) not well known. In this study, we found was significantly up-regulated NSCLC tissues compared with matched normal...
Abstract Objective MiRNAs are considered to be crucial for NSCLC’s initiation and development. have been widely identified in NSCLC. However, the role of miR-126 NSCLC has not fully explained.Methods Expression was evaluated by analyzing common data sets Gene Omnibus(GEO) database reviewing former thesis papers. Three mRNA datasets, GSE18842, GSE19804 GSE101929, from GEO indentify differentially expressed genes (DEG). We prognosed target hsa-miR-126-5p using TargetScan analyzed gene overlap...