A5016871640- Nanoparticle-Based Drug Delivery
- Nanoplatforms for cancer theranostics
- RNA Interference and Gene Delivery
- Natural product bioactivities and synthesis
- Graphene and Nanomaterials Applications
- Multiple Myeloma Research and Treatments
- Characterization and Applications of Magnetic Nanoparticles
- Phytochemistry and Biological Activities
- Advanced biosensing and bioanalysis techniques
- Advanced Nanomaterials in Catalysis
- Advancements in Transdermal Drug Delivery
- Toxin Mechanisms and Immunotoxins
- Advanced Drug Delivery Systems
- Cancer, Hypoxia, and Metabolism
- Lanthanide and Transition Metal Complexes
- Plant-based Medicinal Research
- Phytochemistry and Bioactive Compounds
- Flavonoids in Medical Research
- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer Mechanisms and Therapy
- Pharmacological Effects of Natural Compounds
- PI3K/AKT/mTOR signaling in cancer
- Cancer therapeutics and mechanisms
- Glycosylation and Glycoproteins Research
- Parkinson's Disease Mechanisms and Treatments
Southeast University
2016-2025
State Key Laboratory of Digital Medical Engineering
2016-2025
Zhejiang University
2024-2025
Jingning County People's Hospital
2025
Nanjing Tech University
2023-2024
Nanjing University
2024
Huazhong University of Science and Technology
2024
Changsha University
2023
Xi’an Jiaotong-Liverpool University
2022
Sun Yat-sen University
2018-2021
Breast cancer develops from local tissue but is characterized by a distinct metastatic pattern involving regional lymph nodes and distant organs, which the primary cause of high mortality in breast patients. Herein, optimal docking nanoparticles (NPs) composed laurate-functionalized Pt(IV) prodrug (Pt(lau)), human serum albumin (HSA), lecithin were predicted computational modeling, prepared nanoprecipitation, validated fluorescence spectroscopy. As macrophages have been reported to be...
Aim: Investigated the self-assembly and characterization of novel antifouling polyethylene glycol (PEG)-coated iron oxide nanoparticles as nanoprobes for magnetic resonance imaging (MRI) contrast agent. Method: Monodisperse oleic acid-coated superparamagnetic cores are synthesized by thermal decomposition oleate. The behavior between PEG-lipid conjugates in water their characteristics confirmed transmission electron microscope, X-ray diffraction, thermogravimetric analysis, Fourier transform...
Iron oxide nanoparticles (IONPs) are chemically inert materials and have been mainly used for imaging applications drug deliveries. However, the possibility whether they can be as therapeutic drugs themselves has not yet explored. We reported here that Fe2O3 (NPs) protect hearts from ischemic damage at animal, tissue cell level. The cardioprotective activity of NPs requires integrity is dependent upon their surface charges molecules were integrated into nanoparticles. Also, showed no...
Abstract: Natural polyelectrolyte multilayers of chitosan (CHI) and alginate (ALG) were alternately deposited on doxorubicin (DOX)-loaded poly (lactic-co-glycolic acid) (PLGA) nanoparticles (NPs) with layer by self-assembly to control drug release for antitumor activity. Numerous factors which influenced the multilayer growth nano-colloidal particles studied: concentration, NaCl concentration temperature. Then regime CHI/ALG was elucidated. The coated NPs characterized transmission electron...
Ophiopogonin B (OP-B) is a bioactive component of Radix Ophiopogon Japonicus, which often used in Chinese traditional medicine to treat pulmonary disease. However, whether or not OP-B has any potential antitumor activity been reported. Here, we show that the non-small cell lung cancer (NSCLC) lines NCI-H157 and NCI-H460 treated with grow more slowly accumulate vacuoles their cytoplasm compared untreated control cells. Flow cytometric analysis showed cells were arrested G0/G1 phase. Nuclear...
Nanostructured functional materials have demonstrated their great potentials in medical applications, attracting increasing attention because of the opportunities cancer therapy and treatment other ailments. This article reviews problems recent advances development magnetic NPs for drug delivery.
SOD-like activity of CeO2 nanoparticles (Ce NPs) is driven by Ce3+/Ce4+, high oxidative stress can oxidize Ce3+ to reduce the ratio inactivating SOD Ce NPs. Herein, we found Au@Ce NPs, assembled Au NPs and exhibited high-performance mimetic enzyme even upon oxidation H2O2. supported nano-Au acquire electrons from through enhanced localized surface plasmon resonance (LSPR), maintaining stability Ce3+/Ce4+ activity. Meanwhile, retained peroxidase function catalase function. As a result,...
Nanomedicine-enhanced immunogenic cell death (ICD) has attracted considerable attention for its great potential in cancer treatment. Even though polyethylene glycol (PEG) is widely recognized as the gold standard surface modification of nanomedicines, some shortcomings associated with this PEGylation, such hindered endocytosis and accelerated blood clearance phenomenon, have been revealed recent years. Notably, polysarcosine (PSar) a highly biocompatible polymer can be finely synthesized by...
Chemotherapy-induced myelosuppression (CIM) significantly impairs hematopoiesis. Trilaciclib (TC), originally developed for oncology application, is the only FDA-approved CDK4/6 inhibitor CIM, which effectively protects bone marrow cells by inhibiting their proliferation. In this study, a series of TC derivatives were designed and synthesized as inhibitors (CDK4/6i) alleviating CIM. Among these, 42 displayed potent inhibitory activity (IC50 = 11 nM), lower cytotoxicity (CC50 > 100 μM) showed...
Purpose The objective of this study is to offer a thorough overview the clinical and pathological characteristics, potential pathogenic genes, treatment modalities, prognoses cohort Chinese individuals diagnosed with Fibro-adipose Vascular Anomaly (FAVA). This aims advance comprehension specific medical condition. Methods A total 15 cases FAVA patients admitted our center between June 2015 December 2023 were included in study. Clinical symptoms, laboratory tests, imaging findings, data...
To investigate the effects of anti-ABCG2 monoclonal antibodies (mAbs) in combination with paclitaxel iron oxide nanoparticles (PTX-NPs) on CD138(-)CD34(-) multiple myeloma (MM) cancer stem cells (CSCs) JJN3 cells.PTX-NPs were prepared using hydrophobic interaction polyoxypropylene chain and oleic acid surface NPs targeted to ABCG2 transporter overexpressing MM CSCs mAbs.The data showed that have strong drug resistance tumorigenicity compared non-MM CSCs. PTX-NPs combined mAbs led a...
Previous reports from our team revealed the significant potential advantage of Mn-Zn ferrite nanoparticles (NPs) in magnetic resonance imaging (MRI), whereas anisotropic NPs reportedly increased blood circulation time nanocarriers. Thus, displayed a huge cancer synchronous diagnosis and treatment, that is, enhanced MRI observation was performed simultaneously when drug-targeted delivery therapy applied to tumor. Here, we developed three shaped (Mn0.63Zn0.37Fe2O4) MNPs used as theranostic...
Poly (ADP-ribose) polymerase-1 (PARP-1) is a potential target for the discovery of chemosensitizers and anticancer drugs. Amentoflavone (
One major obstacle for successful application of nanoparticles in medicine is its potential nanotoxicity on the environment and human health. In this study, we evaluated cytotoxicity effect dimercaptosuccinic acid-coated iron oxide (DMSA-Fe2O3) using cultured aortic endothelial cells (HAECs). Our results showed that DMSA-Fe2O3 culture medium could be absorbed into HAECs, dispersed cytoplasm. The HAECs was dose-dependent, concentrations no more than 0.02 mg/ml had little toxic which were...