A5016828111- Cardiac Fibrosis and Remodeling
- Acute Kidney Injury Research
- Tissue Engineering and Regenerative Medicine
- Viral Infections and Immunology Research
- Orthopaedic implants and arthroplasty
- Coronary Interventions and Diagnostics
- Endoplasmic Reticulum Stress and Disease
- interferon and immune responses
- Acute Myocardial Infarction Research
- Cancer, Hypoxia, and Metabolism
- Trypanosoma species research and implications
- RNA Research and Splicing
- Sepsis Diagnosis and Treatment
- Cardiac and Coronary Surgery Techniques
- Genetic Associations and Epidemiology
- Alcohol Consumption and Health Effects
- Cardiomyopathy and Myosin Studies
- Mesenchymal stem cell research
- Cardiovascular Function and Risk Factors
- Vascular Procedures and Complications
- Atherosclerosis and Cardiovascular Diseases
- Heat shock proteins research
- Autophagy in Disease and Therapy
- Inflammatory Biomarkers in Disease Prognosis
- Congenital heart defects research
Zhongshan Hospital
2012-2025
Fudan University
2012-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2025
The First Affiliated Hospital, Sun Yat-sen University
2012-2024
Sun Yat-sen University
2012-2024
Shanghai Institute of Hematology
2021-2024
Mitochondrial aldehyde dehydrogenase-2 (ALDH2) has been characterized as an important mediator of endogenous cytoprotection in the heart. This study was designed to examine role ALDH2 knockout (KO) regulation cardiac function after endoplasmic reticulum (ER) stress. Wild-type (WT) and KO mice were subjected a tunicamycin challenge, echocardiographic property examined. Protein levels six items—78 kDa glucose-regulated protein (GRP78), phosphorylation eukaryotic initiation factor 2 subunit α...
Bone-marrow-derived mesenchymal stem cells (BM-MSCs) were found to markedly increase atherosclerotic lesion size. The aim of this paper was investigate whether BM-MSCs contribute vascular remodeling and calcification after balloon injury in hyperlipidemic rats. Labeled the rats injury. Comparing group, transferred significantly triggered negative remodeling, characterized by changes index (<mml:math...
Dilated cardiomyopathy (DCM) is characterized by left ventricular dilation and cardiac fibrosis. Emerging evidence indicated that endothelial‑to‑mesenchymal transition (Endo‑MT) a crucial event during organ This study was performed to clarify whether Endo‑MT contributed the progression of fibrosis in DCM. Cardiac samples from patients with DCM control were obtained. The presence endothelial markers, cluster differentiation (CD)31 vascular (VE)‑cadherin, mesenchymal α smooth muscle actin...
Background: Whether the role of plasma heat shock protein 70 (HSP70) in acute myocardial infarction (AMI) is protective or detrimental remains debated, and relationship between HSP70 total occlusion elusive. Methods: A 112 patients with primary diagnosis AMI 52 chronic coronary syndrome (CCS) were enrolled into study. Plasma level was determined by ELISA on day 1 7 after onset examined before angiography CCS. Peak NT-proBNP, high-sensitivity C-reactive (CRP), troponin T (cTnT), left...
Guide extension catheters (GEC) are widely applied to cope with insufficient backup support in complex percutaneous coronary intervention (PCI). In the study, we aim evaluate feasibility and safety a novel 5-4F tapered GEC used lesion. The single-center retrospective study enrolled total of 615 patients, whom 5F or Expressman was facilitate PCI procedure. Demographic procedural data were collected. 295 patients 320 patients. average age 63.6 ± 11.0 years 81.6% male. Severe calcification...
To test whether olmesartan ameliorates cardiac diastolic dysfunction in spontaneously hypertensive rats (SHRs) through calcineurin pathway.Twenty-four male SHRs of 6 months were divided into saline- (n = 12) and olmesartan-treated groups. Age-matched WKY served as controls. Saline (10 mL·kg·d) or the same volume liquor (2.5 mg·kg·d) was administered by gavage for 3 months. Heart rate, systolic blood pressure, structure, function histological studies determined. Expression downstream NFAT3...
Background: Atherosclerosis threatens cardiovascular health, which is featured by abnormal lipid metabolism and chronic inflammation in arterial wall. Queuine tRNA-Ribosyltransferase 1 (QTRT1) , an enzyme responsible for tRNA modification at the wobble base. Research Questions: It unclear whether function of QTRT1 involved non-cancer cells tissues, especially mainly orchestrated liver. Aims: We aimed to explore role deficiency hyperlipidemia, liver steatosis atherosclerosis. Methods:...
ABSTRACT Aims Despite the tremendous improvement in therapeutic medication and intervention for coronary atherosclerotic disease (CAD), residual risks remain. Exome sequencing enables identification of rare variants susceptibility genes early‐onset (EOCAD) with well‐controlled conventional risk factors. Methods We performed whole‐exome subjects who had no factors, defined as higher body mass index, smoking, hypertension dyslipidemia, screened from 1950 patients EOCAD (age ≤ 45 years, at...
The aim of this study was to clarify the efficacy early goal-directed renal replacement therapy (GDRRT) for treatment cardiorenal syndrome (CRS) patients after acute decompensated heart failure (ADHF).In retrospective, observational study, we enrolled 54 in GDRRT group and 63 late group. Baseline characteristics, clinical data at initiation time, outcome were collected several parameters compared analyzed between 2 groups.The urine volume time higher than that (1,060.3 ± 332.1 vs. 300.5...
Abstract Background: Endothelial-to-mesenchymal transition (Endo-MT) is associated with myocardial fibrosis in dilated cardiomyopathy (DCM). induced by coxsackievirus B3 (CVB3) cardiac microvascular endothelial cells (CMVECs). Bone morphogenetic protein 7 (BMP7) significantly inhibits Endo-MT and the progression of fibrosis. The study was aimed to investigate effect underlying mechanism BMP7 on induce CVB3 infection vivo. Methods: BALB/c mice were intraperitoneally injected viral myocarditis...
<h3>Objectives</h3> To investigate if calcineurin pathway is involved in cardiac fibroblasts proliferation, transdifferentiation and apoptosis induced by mechanical stretch. <h3>Methods</h3> Primary from 1- to 2-day-old Sprague-Dawley rats were isolated trypsinization purified differential anchoring velocity technology. The cultured cells of passage 2-3 divided into: control group, stretch group (MS group), siRNA + (CaN-siRNA MS FK506 (FK506 overexpression (CaN-overex group). Calcineurin...
Mitochondrial aldehyde dehydrogenase-2 (ALDH2) has been characterized as an important mediator of endogenous cytoprotection in the heart. This study was designed to examine role knockout (KO) pathogenesis heart underwent endoplasmic reticulum (ER) stress induction. Wild-type (WT) and ALDH2 KO mice were subjected tunicamycin challenge echocardiographic examination performed. Protein levels GRP78, p-eIF2α, CHOP, phosphorylation Akt, p47phox NADPH oxidase, 4-hydroxynonenal determined by Western...