A5115604570- Coronary Interventions and Diagnostics
- Cardiac Imaging and Diagnostics
- Acute Myocardial Infarction Research
- Trigeminal Neuralgia and Treatments
- Botulinum Toxin and Related Neurological Disorders
- Nuclear Receptors and Signaling
- Facial Nerve Paralysis Treatment and Research
- Cardiovascular Function and Risk Factors
- Advanced MRI Techniques and Applications
- Cardiac Fibrosis and Remodeling
- Antiplatelet Therapy and Cardiovascular Diseases
- Cardiomyopathy and Myosin Studies
- Atherosclerosis and Cardiovascular Diseases
- Lipoproteins and Cardiovascular Health
- Macrophage Migration Inhibitory Factor
- Cerebrovascular and Carotid Artery Diseases
- MicroRNA in disease regulation
- Metabolomics and Mass Spectrometry Studies
- Cardiac Ischemia and Reperfusion
- Cardiac Valve Diseases and Treatments
- Cardiovascular Issues in Pregnancy
- Cancer-related molecular mechanisms research
- Gut microbiota and health
- Circular RNAs in diseases
- Image Enhancement Techniques
The First Affiliated Hospital, Sun Yat-sen University
2014-2025
Zhongshan Hospital
2016-2025
Fudan University
2016-2025
Sun Yat-sen University
2014-2025
Longhua Hospital Shanghai University of Traditional Chinese Medicine
2023-2025
Shanghai University of Traditional Chinese Medicine
2023-2025
Nanjing University of Chinese Medicine
2020-2025
National Clinical Research Center for Digestive Diseases
2023-2025
University of Shanghai for Science and Technology
2024-2025
Shanghai Center for Brain Science and Brain-Inspired Technology
2023-2025
The mechanisms underlying ageing-induced vascular remodelling remain unclear. This study investigates the role and of cytoplasmic deacetylase sirtuin 2 (SIRT2) in remodelling.
Recombinant granulocyte colony-stimulating factor (G-CSF), with a direct repair effect on injured cardiomyocytes against myocardial infarction ischemia-reperfusion-injury (IRI), displays poor owing to the limited cardiac targeting efficacy. There are almost no reports of nanomaterials that deliver G-CSF IRI site. Herein, we propose way protect by constructing one layer nitric oxide (NO)/hydrogen sulfide (H2S) nanomotors its outside. NO/H2S specific chemotactic ability high expression...
Cardiovascular disease (CVD), principally heart and stroke, is the leading cause of death for both males females in developed countries. Aspirin most widely used tested antiplatelet drug CVD, it proven to be cornerstone therapy treatment prevention CVD clinical trials various populations. In acute coronary syndrome, thrombotic Kawasaki's disease, use aspirin can decrease mortality recurrence cardiovascular events. As secondary prevention, believed effective stable angina, revascularization,...
Although non-optimum ambient temperature is a major non-traditional risk factor for acute myocardial infarction, there no prior knowledge on whether could differentially affect infarction with obstructive coronary artery disease (MI-CAD) and non-obstructive arteries (MINOCA). Using the Chinese Cardiovascular Association database-Chest Pain Center Registry, nationwide, time-stratified, case-crossover investigation was conducted from 2015 to 2021. Meteorological data were obtained an...
Early diagnosis and treatment effectiveness of early-onset coronary artery disease (EOCAD) are crucial, non-invasive predictive biomarkers needed for young adults. We aimed to evaluate the usefulness triglyceride-glucose (TyG) index, a novel marker insulin resistance, in identifying CAD patients predicting their risk developing target lesion failure (TLF).We recruited EOCAD (luminal narrowing ≥ 70%) controls free from < 30%), both aged 45 years or younger, 38 hospitals China between 2017...
Abstract Background Indobufen is widely used in patients with aspirin intolerance East Asia. The OPTION trial launched by our cardiac center examined the performance of indobufen based dual antiplatelet therapy (DAPT) after percutaneous coronary intervention (PCI). However, vast majority acute syndrome (ACS) and were excluded. We aimed to explore this question a real-world population. Methods Patients enrolled ASPIRATION registry grouped according DAPT strategy that they received PCI....
Traumatic brain injury (TBI) can induce intestinal inflammatory response and mucosal injury. Antioxidant transcription factor nuclear erythroid 2-related 2 (Nrf2) has been shown in our previous studies to prevent oxidative stress gut after TBI. The objective of this study was test whether tert-butylhydroquinone (tBHQ), an Nrf2 inducer, protect against TBI-induced mice. Adult male ICR mice were randomly divided into three groups: (1) sham + vehicle group, (2) TBI (3) tBHQ group (<mml:math...
The limited availability and high cost of 7 Tesla (7T) structural MRI hinder its widespread application despite superior imaging quality. This study introduces a High Frequency-Generative Adversarial Network (HF-GAN) to predict three-dimensional 7T-equivalent (P7T) images from standard 3T scans, offering cost-effective alternative. HF-GAN was trained on paired 7T data validated external datasets, including STRATIFY/ESTRA (N=671) ADNI2 (N=643), covering psychiatric neurodegenerative...
Background: It remains unclear how rapidly the collateral circulation regresses after percutaneous coronary intervention (PCI) of chronic total occlusion (CTO). This study aimed to investigate short-term changes myocardial perfusion in predominant donor vessel successful CTO PCI. Methods: A 68 patients who underwent single-photon emission computerized tomography (SPECT) assessment before and within 24–72 hours PCI were retrospectively included into this study. The flow reserve (CFR)...
BACKGROUND: Arrhythmogenic right ventricular cardiomyopathy (ARVC) is an inherited heart disease characterized by irregular rhythms and dysplasia. Sequence variations in desmosomal protein-encoding genes are linked to ARVC development. Effective treatments for lacking. Whereas mRNA-based therapies have shown efficacy humans, their therapeutic potential cardiomyopathies remains unclear. METHODS: Whole-exome sequencing identified a novel DSC2 sequence variation causing autosomal recessive...
Aging is characterized by gradual structural and functional changes in the body over time, with intervertebral disc degeneration (IVDD) representing a key manifestation of spinal aging major contributor to low back pain (LBP). This study utilized bioinformatics machine learning approaches identify aging-related biomarkers associated IVDD whole blood samples. By analyzing GEO datasets alongside databases such as GeneCards, HAGR, AgeAnno, we identified 15 differentially expressed genes...
To determine the relationship of retinal microcirculatory responses to cognitive function following yoga training in patients with Parkinson's disease (PD). Twenty diagnosed PD were recruited, and imaging was successful on 17 (age 71.8 ± 7.2 years old, nine females). Retinal capillary perfusion density (CPD) imaged using optical coherence tomography angiography (OCTA), blood flow (RBF) a imager (RFI). All participated three 1-hour YogaCue or Hatha classes per week for 24 consecutive weeks....