A5087718520- Acute Kidney Injury Research
- Dialysis and Renal Disease Management
- Chronic Kidney Disease and Diabetes
- Alcohol Consumption and Health Effects
- Gout, Hyperuricemia, Uric Acid
- Renal Diseases and Glomerulopathies
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Parathyroid Disorders and Treatments
- MRI in cancer diagnosis
- Central Venous Catheters and Hemodialysis
- Advanced Neuroimaging Techniques and Applications
- Cardiac Arrest and Resuscitation
- Sepsis Diagnosis and Treatment
- Diet, Metabolism, and Disease
- Inflammatory Biomarkers in Disease Prognosis
- Case Reports on Hematomas
- Fetal and Pediatric Neurological Disorders
- Muscle and Compartmental Disorders
- Liver Disease Diagnosis and Treatment
- Magnesium in Health and Disease
- Autopsy Techniques and Outcomes
- Cardiac, Anesthesia and Surgical Outcomes
- Advanced MRI Techniques and Applications
- Potassium and Related Disorders
- Trauma and Emergency Care Studies
Shanghai Medical Information Center
2021-2023
Shanghai Institute of Hematology
2014-2023
Fudan University
2012-2023
Zhongshan Hospital
2013-2023
The First Affiliated Hospital, Sun Yat-sen University
2011-2023
Sun Yat-sen University
2011-2023
Shanghai Blood Center
2014-2022
Shanghai Medical College of Fudan University
2014-2022
Zhongshan Hospital of Xiamen University
2021
Shanghai Clinical Research Center
2019
ABSTRACT Background This study aimed to characterize the temporal trends of chronic kidney disease (CKD) burden in China during 1990–2019, evaluate their age, period and cohort effects, predict for next 10 years. Methods Data were obtained from Global Burden Disease (GBD) 2019 study. Join-point regression model was used estimate average annual percentage change (AAPC) CKD prevalence mortality, age-period-cohort analysis effects. We extended autoregressive integrated moving (ARIMA) 2020–2029....
Background Because chronic kidney disease (CKD) is a worldwide problem, accurate pathological and functional evaluation required for planning treatment follow‐up. Intravoxel incoherent motion diffusion‐weighted imaging (IVIM‐DWI) can assess both capillary perfusion tissue diffusion may be helpful in evaluating renal function pathology. Purpose To evaluate alterations CKD by applying IVIM‐DWI. Study Type Prospective study. Subjects In all, 72 patients who biopsy 20 healthy volunteers. Field...
Abstract Background Cardiac surgery‐associated acute kidney injury (CSA‐AKI) is a well‐recognized complication with an ominous outcome. Hypothesis Bayesian networks (BNs) not only can reveal the complex interrelationships between predictors and CSA‐AKI, but predict individual risk of CSA‐AKI occurrence. Methods During 2013 2015, we recruited 5533 eligible participants who underwent cardiac surgery from tertiary hospital in eastern China. Data on demographics, clinical laboratory information...
Background Chronic kidney disease (CKD) is a worldwide health problem, precise functional and pathological assessment beneficial to better treatment. Diffusion kurtosis imaging (DKI) can evaluate non‐Gaussian diffusion may help assess renal pathology function. Purpose To alterations in CKD using DKI compared with diffusion‐weighted (DWI). Study Type Prospective study. Population 70 patients 20 healthy volunteers. Field Strength 1.5 T. Assessment All participants underwent DKI, apparent...
// Na Liu 1 , Liuqing Xu Yingfeng Shi Lu Fang Hongwei Gu Hongrui Wang Xiaoqiang Ding 2 and Shougang Zhuang 1, 3 Department of Nephrology, Shanghai East Hospital, Tongji University School Medicine, 200120, China Division Zhongshan Fudan University, 200032, Rhode Island Hospital Brown Providence, RI 02903, USA Correspondence to: Zhuang, email: szhuang@lifespan.org Ding, ding.xiaoqiang@zs-hospital.sh.cn Keywords: hyperuricemic nephropathy, ERK1/2, TGF-β/Smad signaling pathway, urate...
Purpose: Acute kidney injury (AKI) is a prominent risk factor for the development of chronic disease (CKD). To date, related mechanism and effective therapy have not been rigorously explored. The present study aims to investigate reno-protection hydrogen-rich saline (HRS) against ischemia/reperfusion (IR)-induced AKI. Methods: Adult male C57 mice were randomly allocated into three groups: Sham, IR, IR+HRS. Renal IR model was generated via 35 min occlusion bilateral pedicles, then,...
Background: A few studies have shown that urinary kidney injury molecule-1 (uKIM-1) levels are increased in acute (AKI); however, the correlation between uKIM-1 and histological tubular injury, which is considered to be gold standard for evaluating renal damage predicting prognosis, still unclear. We performed this study determine whether predicted value of correlated with KIM-1 (tKIM-1) expression tissue AKI patients.Methods: This retrospective recruited 14 healthy individuals 27...
Alcohol consumption is a major threat to global health. The aim of the present study was explore association between alcohol and chronic kidney disease (CKD) in Chinese population.A total 4664 participants, aged ≥18 years, who participated baseline survey 1997 were followed up 2009 China Health Nutrition Survey (CHNS), recruited current study. Data on obtained using standardized questionnaires, with CKD (defined as eGFR <60 mL/min/1.73 m2) outcome. results showed that 37.3% participants had...
Abstract C hina has a large population and bears heavy burden of kidney diseases. Acute injury ( AKI ) is increasingly prevalent in associated with severe morbidity mortality. The inadequacies early diagnosis management remain the major challenges to hinese nephrologists. There an urgent need for nationwide, or even global effort increase awareness devastating effects , develop professional preventive strategies, as well achieve intervention. In this article, we review increasing incidence...
Abstract Background We aimed to explore the association between long-term drinking behavior change patterns with hyperuricemia (HUA) in Chinese community adults. Methods This study was designed as a community-based unbalanced cohort involving 4127 adults aged 18 ~ 75 years, derived from China Health and Nutrition Survey (CHNS) 1997 2009. Drinking were categorized into: never drinking, quitting continued drinking. The alcoholism, type, frequency of further categorized. applied logistic...
Hyperphosphataemia in patients with advanced chronic kidney disease (CKD) is associated adverse outcomes, including vascular calcification and higher mortality rates. While phosphate lowering an integral aspect of CKD management, the efficacy safety binders a contemporary cohort Chinese haemodialysis (who have different genetics dietary patterns than other populations) has not been previously described. Moreover, sparse data are available on strategies for optimal dose titration when...
The aim of the study was to explore associations between elevated red cell distribution width (RDW) and acute kidney injury (AKI) in patients undergoing cardiac surgery (CS-AKI). Preoperative, intraoperative postoperative data 10,274 surgery, including demographic data, were prospectively collected from January 2009 December 2014. Propensity score matching used on basis clinical characteristics preoperative variables. An RDW defined as difference 24 h after latest before surgery. A total...
To explore the association of body mass index (BMI) with risk developing acute kidney injury after cardiac surgery (CS-AKI) and for AKI requiring renal replacement therapy (AKI-RRT) surgery.Clinical data 8,455 patients undergoing surgery, including demographic preoperative, intraoperative, postoperative were collected. Patients divided into underweight (BMI <18.5), normal weight (18.5≤ BMI <24), overweight (24≤ <28), obese ≥28) groups. The influence on CS-AKI incidence, duration hospital,...
In this study, we applied a composite index of neutrophil-lymphocyte * platelet ratio (NLPR), and explore the significance dynamics perioperative NLPR in predicting cardiac surgery-associated acute kidney injury (CSA-AKI).During July 1st December 31th 2019, participants were prospectively derived from 'Zhongshan Cardiovascular Surgery Cohort'. was determined using neutrophil counts, lymphocyte count at two-time points. Dose-response relationship analyses to delineate non-linear odds (OR)...
<i>Background/Aims:</i> The role of ischemic pretreatment in long-term changes after renal ischemia-reperfusion (I/R) injury remains unknown. In this study, we mainly aimed to investigate the effect pretreatments with different durations on development tubulointerstitial fibrosis and functional impairment following acute I/R. <i>Methods:</i> We established a rat model warm I/R, clamping both pedicles for 40 min followed by reperfusion; experiment was up 10 weeks....
Renal tubulointerstitial fibrosis is the most common pathway of progressive kidney injury, leading to end-stage renal disease. At present, no effective prophylactic treatment method available. This study investigated anti-fibrotic effects total flavonoids (TFs) extracted from leaves Carya Cathayensis in vivo and vitro, explored underlying mechanisms.Anti-fibrotic TFs were measured using a mouse model unilateral ureteral obstruction (UUO) transforming growth factor-β1 (TGF-β1)-treated tubular...
Based on the admission data, we applied XGBoost algorithm to create a prediction model estimate AKI risk in patients with hepatobiliary malignancies and then compare its capacity logistic model.We reviewed clinical data of 7968 589 liver/gallbladder cancer admitted Zhongshan Hospital during 2014 2015. They were randomly divided into training set test set. Data collected from electronic medical record system. LASSO-logistic used develop models, respectively. The performance measures included...
Introduction The question of whether the increased burden chronic kidney disease (CKD) is caused by interaction hyperuricemia and cardiovascular (CVD) risk factors or accelerated aging remains unresolved. purpose this study to better understand effect modification hyperuricemia, risk, age on CKD among Chinese population. Methods This cross-sectional 8243 participants was derived from China Health Nutrition Survey (CHNS) in 2009. Inclusion criteria included ≥18 years, non-pregnancy, no...