<i>Objectives:</i> This study’s objective was to determine the incidence and mortality rate of acute kidney injury (AKI) among hospitalized adult patients in a tertiary metropolitan hospital China, evaluate impact AKI on in-hospital mortality, cost length stay (LOS). <i>Methods:</i> Patients who were admitted Zhongshan Hospital, Fudan University, Shanghai, China between September 1st, 2004 June 30th, 2008 involved. The presence severity assessed using absolute...

The aim of the study was to evaluate risk factors for long-term mortality and progressive chronic kidney disease (CKD) after cardiac surgery in patients with normal preoperative renal function postoperative acute injury (AKI). From April 2009 December 2012, we prospectively enrolled 3245 our hospital. primary endpoints included survival rates secondary endpoint incidence a follow-up period 2 years. Acute staged by KDIGO classification. Progressive CKD defined as GFR ≤ 30 mL/min/1.73 m2 or...

Cardiac surgery-associated acute kidney injury (CSA-AKI) is a common complication with poor prognosis. In order to identify modifiable perioperative risk factors for AKI, which existing scores are insufficient predict, dynamic clinical score allow clinicians estimate the of CSA-AKI from preoperative early postoperative periods needed.A total 7233 cardiac surgery patients in our institution January 2010 April 2013 were enrolled prospectively and distributed into 2 cohorts. Among derivation...

Acute kidney injury (AKI) following cardiac surgery is common and associated with poor patient outcomes. Early risk assessment for development of AKI remains a challenge. The combination urinary tissue inhibitor metalloproteinase 2 (TIMP-2) insulin-like growth factor binding protein 7 (IGFBP7) has been shown to be an excellent predictor surgery, but reported studies are predominately non-Asian populations. Adult patients were prospectively enrolled at Zhongshan hospital in Shanghai, China....

Septic acute kidney injury is one of the most common and life-threatening complications in critically ill patients, there no approved effective treatment. We have shown xenon provides renoprotection against ischemia-reperfusion nephrotoxicity rodents via inhibiting apoptosis. Here, we studied effects preconditioning on septic its mechanism.Experimental animal investigation.University research laboratory.Experiments were performed with male C57BL/6 mice, 10 weeks age, weighing 20-25 g.We...

Background: It is widely accepted that chronic renal failure associated with severe alterations of immune system. However, few studies looked into the alteration in earlier stage kidney disease (CKD) patients. To characterize defect CKD patients, we performed lymphocyte subset analysis and explored its relationship to function this population. Methods: 472 patients were enrolled study. Lymphocyte subsets (CD19+, CD3+, CD3+CD4+, CD3+CD8+, CD56+CD16+) determined by flow cytometry. Clinical...

BACKGROUND Dysnatremia is a risk factor for poor outcomes. We aimed to describe the prevalence and outcomes of various dysnatremia in hospitalized patients. High-risk patients must be identified improve prognosis dysnatremia. MATERIAL AND METHODS This prospective study included all adult admitted consecutively university hospital between October 1, 2014 September 30, 2015. RESULTS All 90 889 were this study. According serum sodium levels during hospitalization, incidence hyponatremia...

Backgrounds Despite the potential therapeutic benefits, cell therapy in renal ischemia-reperfusion (I/R) injury is currently limited by low rates of engraftment after systemic delivery. In this study, we investigate whether locally administration through artery can enhance migration and mesenchymal stem cells (MSCs) ischemic kidney. Methods The model I/R was induced 45 min occlusion left pedicle right nephrectomy rat. Followed reperfusion, graded doses CM-Dil labeled MSCs were implanted via...

Background Sepsis-induced acute kidney injury (S-AKI) is a common complication in critically ill patients. Therefore, reliable biomarkers for predicting S-AKI outcomes are necessary. Serum cell-free DNA (cfDNA) circulating extracellular fragment used as noninvasive screening tool many diseases, including sepsis. This study aimed to investigate the prognostic value of cfDNA patients and its relationship with some other parameters.Methods A total 89 admitted intensive care unit (ICU) from June...

To analyze the predictive value of postoperative percent fluid overload (PFO) renal replacement therapy (RRT) for acute kidney injury (AKI) patients after cardiac surgery. Data from 280 surgery between 2005 January and 2012 April were collected retrospective analyses. A receiver operating characteristic (ROC) curve was used to compare values cumulative PFO at different times 90-day mortality. The before RRT initiation 7.9% ± 7.1% median 6.1%. in intensive care unit (ICU) higher death group...

The hepatocyte growth factor (HGF) target pathway plays pivotal renoprotective roles after acute kidney injury. Syndecan-1 (SDC-1) serves as the coreceptor for HGF. Shedding of SDC-1 is involved in various pathological processes. Thus, we hypothesized that ischemia/reperfusion injury induced shedding, and inhibiting shedding would protect against by potentiating activation HGF receptor mesenchymal epithelial transition (c-Met).Expression its sheddases were observed kidneys sham (I/R) mice....

Abstract Background The commonly used recommended criteria for renal recovery are not unequivocal. This study compared five different definitions of in order to evaluate long-term outcomes cardiac surgery associated acute kidney injury (CSA-AKI). Methods Patients who underwent between April 2009 and 2013 were enrolled divided into (AKI) non-AKI groups. primary endpoint was 3-year major adverse events (MAEs) including death, new dialysis progressive chronic disease (CKD). We complete...

Abstract C hina has a large population and bears heavy burden of kidney diseases. Acute injury ( AKI ) is increasingly prevalent in associated with severe morbidity mortality. The inadequacies early diagnosis management remain the major challenges to hinese nephrologists. There an urgent need for nationwide, or even global effort increase awareness devastating effects , develop professional preventive strategies, as well achieve intervention. In this article, we review increasing incidence...

Endothelial dysfunction and chronic inflammatory process are prevalent in patients with end-stage renal disease (ESRD) on maintenance hemodialysis (HD). The aim of this study was to evaluate the acute short-term effects online hemodiafiltration (OL-HDF) versus conventional HD endothelial function inflammation. A prospective, randomized, crossover trial. Twenty stable ESRD undergoing treatments were randomly assigned a 1:1 ratio OL-HDF both for 2 weeks (either followed by or HD). Markers such...

The aim of the study was to explore associations between elevated red cell distribution width (RDW) and acute kidney injury (AKI) in patients undergoing cardiac surgery (CS-AKI). Preoperative, intraoperative postoperative data 10,274 surgery, including demographic data, were prospectively collected from January 2009 December 2014. Propensity score matching used on basis clinical characteristics preoperative variables. An RDW defined as difference 24 h after latest before surgery. A total...

To explore the association of body mass index (BMI) with risk developing acute kidney injury after cardiac surgery (CS-AKI) and for AKI requiring renal replacement therapy (AKI-RRT) surgery.Clinical data 8,455 patients undergoing surgery, including demographic preoperative, intraoperative, postoperative were collected. Patients divided into underweight (BMI <18.5), normal weight (18.5≤ BMI <24), overweight (24≤ <28), obese ≥28) groups. The influence on CS-AKI incidence, duration hospital,...

ObjectivesCumulative fluid overload may influence acute kidney injury (AKI) diagnosis due to the dilution effect. The authors hypothesized a small increase of early postoperative serum creatinine (SCr) adjusted for balance might have superior discrimination ability in subsequent AKI prediction.DesignRetrospective analyses.SettingA single-center study university hospital.ParticipantsThe comprised 1,016 adult patients who underwent elective isolated or combined valve surgery...

Acute kidney injury (AKI) is a common complication after cardiac surgery, and preoperative renal dysfunction an important risk factor. Proteinuria indicates structural damage, but there are few studies on proteinuria the of AKI surgery in patients with dysfunction. This study aimed to elucidate whether can predict dysfunction.Patients stages 3-4 chronic disease (CKD) who underwent were included this retrospective study. was defined according KDIGO criteria. The association between CKD...

Elevated serum uric acid (sUA) is usually associated with a high occurrence of acute ischemic stroke (AIS) in the general population. The aim this study to evaluate role sUA AIS among hemodialysis (HD) patients.We followed up 226 HD patients for 18 months from January 2009 June 2010. parameters included demographic characteristics, duration HD, sUA, albumin, and other parameters. Logistic regression was performed function SUC levels AIS.A total 43 suffered AIS. By univariate logistic...