A5103192238- Blood Coagulation and Thrombosis Mechanisms
- Traumatic Brain Injury and Neurovascular Disturbances
- Protease and Inhibitor Mechanisms
- Iron Metabolism and Disorders
- Intensive Care Unit Cognitive Disorders
- Hemoglobinopathies and Related Disorders
- Respiratory Support and Mechanisms
- Folate and B Vitamins Research
- Dermatologic Treatments and Research
- Anesthesia and Neurotoxicity Research
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Immune Response and Inflammation
Fudan University
2015-2021
Zhongshan Hospital
2015-2021
Shanghai Blood Center
2015
Septic acute kidney injury is one of the most common and life-threatening complications in critically ill patients, there no approved effective treatment. We have shown xenon provides renoprotection against ischemia-reperfusion nephrotoxicity rodents via inhibiting apoptosis. Here, we studied effects preconditioning on septic its mechanism.Experimental animal investigation.University research laboratory.Experiments were performed with male C57BL/6 mice, 10 weeks age, weighing 20-25 g.We...
Tissue factor pathway inhibitor (TFPI) is a physiological of the tissue (TF)-initiated coagulation pathway. Both circulating and tumor cell-associated TFPI significantly reduce cell-induced activation lung metastasis. However, significance endothelial cell-anchored in cancer biology remains largely unexplored. We generated mice with full-length disruption (including TFPIα TFPIβ isoforms) cells, using Cre-LoxP system gene inactivation (GI) strategy. Experimental pulmonary metastasis models...
As activation of the coagulation system is both a consequence and contributor to acute lung injury (ALI), pulmonary coagulopathy has become potential target for therapeutic intervention in ALI patients. We investigated effects possible mechanisms endothelial cell (EC)-anchored tissue factor pathway inhibitor (TFPI) on lipopolysaccharide (LPS)-induced mice. To assess effect EC-anchored TFPI deletion indices, knockout (cKO) mice were generated. Mice instilled by direct intratracheal injection...
Objective: To study the correlation between expression of angiotensin Ⅱ, Ⅱ type 1 receptor (AT1R), 2 (AT2R) and collagen deposition in human keloid. Methods: The keloid from 19 patients normal skin 13 performed with free transplantation hospitalized our unit May 2014 to January 2015 were obtained. expressions AT1R, AT2R detected by immunohistochemical staining, results semi-quantitatively analyzed scoring. was picrosirius-red percentage total calculated. Data processed t test. content...
This study aimed to investigate the relationship between gene polymorphism of methylenetetrahydrofolate reductase (MTHFR) C677T and left ventricular hypertrophy (LVH) in patients with chronic kidney disease (CKD).A total 763 Chinese CKD undergoing genetic testing were included study. The association MTHFR echocardiographic parameters was analyzed through univariate multivariate analyses.We found a remarkably positive LVH indexes, including interventricular septal thickness (F = 3.8; P .022),...