A5060523108- Ferroptosis and cancer prognosis
- Cardiac pacing and defibrillation studies
- Exercise and Physiological Responses
- Mechanical Failure Analysis and Simulation
- Cardiovascular Function and Risk Factors
- MicroRNA in disease regulation
- Dialysis and Renal Disease Management
- Sleep and related disorders
- Human-Animal Interaction Studies
- Alcohol Consumption and Health Effects
- Mechanical stress and fatigue analysis
- Nerve injury and regeneration
- Effects of Environmental Stressors on Livestock
- Heart Failure Treatment and Management
- Neurogenesis and neuroplasticity mechanisms
- Gout, Hyperuricemia, Uric Acid
- Fatigue and fracture mechanics
- Epigenetics and DNA Methylation
- Extracellular vesicles in disease
- Single-cell and spatial transcriptomics
- Immune cells in cancer
- Birth, Development, and Health
- Supramolecular Self-Assembly in Materials
Zhongshan Hospital
2021-2025
Fudan University
2021-2025
Shanghai Institute of Hematology
2025
Shanghai Blood Center
2022-2025
Sichuan University
2025
Ministry of Agriculture and Rural Affairs
2024
Civil Aviation Flight University of China
2024
Shanghai Medical Information Center
2021-2022
Abstract Microenvironment mechanics plays a vital role in regulating morphogenesis and immune response after injury, but their exploration has been hindered by the fragile mechanical strength oxidative physiological environment spinal cord injury (SCI). Here, we engineered self-assembly hydrogels of enantiomeric peptides with neural tissue-matching properties to persistently manipulate cellular membrane tension mechanotransduction through stereo conformational recognition consequent protein...
Aging is a known driver of chronic kidney disease (CKD), yet the genetic mechanisms linking these two conditions remain unclear. This study aims to explore role CD8+ central memory T (TCM) cells and their associated gene expression in interaction between aging CKD. Peripheral blood samples from young controls, elderly individuals, CKD patients were analyzed using single-cell RNA sequencing investigate immune cell populations. Expression quantitative trait loci (eQTL) Mendelian randomization...
Abstract The link between ferroptosis, a form of cell death mediated by iron and acute kidney injury (AKI) is recently gaining widespread attention. However, the mechanism crosstalk cells in pathogenesis progression remains unexplored. In our research, we performed non-negative matrix decomposition (NMF) algorithm on single-cell RNA sequencing data based specifically focusing ferroptosis-associated genes. Through combination with pseudo-time analysis, cell–cell interaction analysis SCENIC...
Abstract Aims Heart failure (HF) is a common complication and the leading cause of mortality in maintenance haemodialysis (MHD) patients. Few studies have investigated heart with preserved ejection fraction (HFpEF), which known to affect majority The objective this study explore prevalence, clinical profiles, diagnosis, risk factors prognosis MHD patients HFpEF. Methods results Four hundred thirty‐nine haemodialyzsed for over 3 months were enrolled evaluated HF according European Society...
Abstract When an aircraft was performing flight tasks, it found that one connecting bolt of No. 3 main wheel missing during the short stop inspection. The uses 148 ups and downs this time, use time is significantly lower than normal. It inferred high probability its fracture not caused by long-term use, speculated reason related to quality itself. Material analysis showed there were no obvious abnormalities in material, slight scratches near bolt. fatigue position located at transition arc...
Clear cell renal carcinoma (ccRCC) is the most predominate pathological subtype of carcinoma, causing a recurrence or metastasis rate as high 20% to 40% after operation, for which effective prognostic signature urgently needed. The mRNA and miRNA profiles ccRCC specimens were collected from Cancer Genome Atlas. MiRNA-pair risk score (miPRS) each pair was generated validated by univariate multivariate Cox proportional hazards regression analysis. Functional enrichment performed, immune cells...