A5065533886- Renal Diseases and Glomerulopathies
- Chronic Kidney Disease and Diabetes
- Renal and related cancers
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Liver Disease Diagnosis and Treatment
- Renin-Angiotensin System Studies
- Liver physiology and pathology
- Complement system in diseases
- Nitric Oxide and Endothelin Effects
- Systemic Sclerosis and Related Diseases
- Platelet Disorders and Treatments
- Acute Kidney Injury Research
- Cell Adhesion Molecules Research
- Systemic Lupus Erythematosus Research
- Angiogenesis and VEGF in Cancer
- Liver Disease and Transplantation
- Renal and Vascular Pathologies
- Macrophage Migration Inhibitory Factor
- Muscle and Compartmental Disorders
- RNA Research and Splicing
- Abdominal vascular conditions and treatments
- Connective Tissue Growth Factor Research
- Vasculitis and related conditions
- Renal cell carcinoma treatment
- IL-33, ST2, and ILC Pathways
RWTH Aachen University
2014-2024
Universitätsklinikum Aachen
2007-2023
RELX Group (United States)
2020
Westfälische Hochschule
2010-2017
FH Aachen
2003-2013
University Hospital Leipzig
2012
Medical College of Wisconsin
2010
Augusta-Kranken-Anstalt
2010
University of Bonn
2004-2007
Slovak Medical University
2007
VEGF165, the most abundant isoform in man, is an angiogenic cytokine that also regulates vascular permeability. Its function renal glomerulus, where it expressed visceral epithelial and mesangial cells, unknown. To assess role of VEGF165 glomerular disease, we administered a novel antagonist — high-affinity, nuclease-resistant RNA aptamer coupled to 40-kDa polyethylene glycol (PEG) normal rats with mesangioproliferative nephritis, passive Heymann nephritis (PHN), or puromycin aminonucleoside...
Glomerulonephritis (GN) is a major cause of renal failure. This study sought to determine whether intrarenal injection rat mesenchymal stem cells (MSC) can preserve function in progressive model GN. Early GN (day 10), fluorescently labeled MSC localized more than 70% glomeruli, ameliorated acute failure, and reduced glomerular adhesions. Fifty days later, proteinuria had progressed controls 40 +/- 25 mg/d but stayed low MSC-treated rats (13 4 mg/d; P < 0.01). Renal on day 60 the group was...
<h3>Abstract</h3> Drug intake is known to be under the influence of social context. We have recently shown that presence a peer influences drug in both rats and humans. Whether or not acoustic communications between peers play role during cocaine sucrose self-administration (SA) was investigated here, using playback ultrasonic vocalizations (USV) at 50- 22-kHz, conveying respectively positive negative internal affective states adult rats. To assess neurobiological substrate potential USV on...
Renal fibrosis is the final common pathway of most progressive renal diseases. C5 was recently identified as a risk factor for liver fibrosis. This study investigated role in development tubulointerstitial by (1) induction wild-type and C5(-/-) mice unilateral ureteral ligation (UUO) (2) investigation effects C5a receptor antagonist (C5aRA) UUO. In mice, when compared with controls, markers (Sirius Red, type I collagen, fibronectin, alpha-smooth muscle actin, vimentin, infiltrating...
Kidney diseases impart a vast burden on affected individuals and the overall health care system. Progressive loss of renal parenchymal cells functional decline following injury are often observed. Notch-1 -2 receptors crucially involved in nephron development contribute to inflammatory kidney diseases. We specifically determined participation receptor Notch-3 tubulointerstitial responses. Here we show by heat map analyses that transcripts up-regulated human A similar response was...
Pathologic proliferation of mesangial and parietal epithelial cells (PECs) is a hallmark various glomerulonephritides. Macrophage migration inhibitory factor (MIF) pleiotropic cytokine that mediates inflammation by engagement receptor complex involving the components CD74, CD44, CXCR2, CXCR4. The proliferative effects MIF may involve CD74 together with coreceptor PEC activation marker CD44. Herein, we analyzed local glomerular MIF/CD74/CD44 signaling in MIF, CD44 were upregulated glomeruli...
Skeletal muscle wasting is commonly associated with chronic kidney disease (CKD), resulting in increased morbidity and mortality. However, the link between function remains poorly understood. Here, we took a complementary interorgan approach to investigate skeletal CKD. We identified production elevated blood levels of soluble pro-cachectic factors, including activin A, directly linking experimental human CKD programs. Single-cell sequencing data expression A specific cell populations...
Abstract. Glomerular mesangial cell proliferation and/or matrix accumulation characterizes many progressive renal diseases. Rats with mesangioproliferative glomerulonephritis were treated from day 3 to 7 after disease induction a high-affinity oligonucleotide aptamerantagonist against platelet-derived growth factor-B chain (PDGF-B). In comparison nephritic rats that received vehicle or scrambled aptamer, treatment the PDGF-B aptamer led significant reduction of changes, glomerular...
Parietal epithelial cells (PECs) of the renal glomerulus contribute to formation both cellular crescents in rapidly progressive GN and sclerotic lesions FSGS. Subtotal transgenic ablation podocytes induces FSGS but effect specific PECs is unknown. Here, we established an inducible mouse allow subtotal PECs. Proteinuria developed during doxycycline-induced fully reversed 26 days after termination doxycycline administration. The was focal, with only 30% glomeruli exhibiting histologic changes;...
In vitro studies identified Y-box-binding protein (YB)-1 as a key regulator of inflammatory mediators. this study, we observed increased levels secreted YB-1 in sera from sepsis patients. This led us to investigate the vivo role murine models acute peritonitis following LPS injection, sterile renal inflammation unilateral ureteral obstruction, and experimental pyelonephritis. injection enhanced de novo secretion into urine peritoneal fluid LPS-treated mice. Furthermore, could demonstrate...
The role of IL-6 signaling in renal diseases remains controversial, with data describing both anti-inflammatory and proinflammatory effects. can act via classic signaling, engaging its two membrane receptors gp130 receptor (IL-6R). Alternatively, trans-signaling requires soluble IL-6R (sIL-6R) to on IL-6R-negative cells that express gp130. Here, we characterize the pathways crescentic nephritis. Patients nephritis had significantly elevated levels serum urine. Similarly, nephrotoxic...