A5074426546- Advanced Glycation End Products research
- Chronic Kidney Disease and Diabetes
- Natural Antidiabetic Agents Studies
- Dialysis and Renal Disease Management
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Diet, Metabolism, and Disease
- Biochemical effects in animals
- Acute Kidney Injury Research
- Adipokines, Inflammation, and Metabolic Diseases
- Alcohol Consumption and Health Effects
- Blood Pressure and Hypertension Studies
- Renal Diseases and Glomerulopathies
- Birth, Development, and Health
- Diet and metabolism studies
- Eicosanoids and Hypertension Pharmacology
- Fatty Acid Research and Health
- Vitamin D Research Studies
- Renin-Angiotensin System Studies
- Diabetes Management and Research
- Obesity, Physical Activity, Diet
- Adipose Tissue and Metabolism
- Gout, Hyperuricemia, Uric Acid
- Liver Disease Diagnosis and Treatment
- Electrolyte and hormonal disorders
- Diabetes and associated disorders
Comenius University Bratislava
2016-2025
Faculty (United Kingdom)
2018
John Radcliffe Hospital
2017-2018
Institute of Materials and Machine Mechanics of the Slovak Academy of Sciences
2018
Slovak Academy of Sciences
2018
Slovak Medical University
2004-2017
University of Pavol Jozef Šafárik
2017
NILU
2009
Krankenhaus St. Elisabeth und St. Barbara
2007-2009
RWTH Aachen University
2007
Industrial processing of infant formulas (IFs) induces the formation Maillard products, namely N ɛ ‐(carboxymethyl)lysine (CML). CML content is expected to be several times higher in IFs than fresh human breast milk. To elucidate whether absorbed from into bloodstream, concentration plasma and urine were analyzed 6‐month‐old infants (34 fed 25 exclusively with IFs) 56 samples milk 16 commercial IFs. We found that contain amounts compared mother's (median: 70‐fold; range: 28‐ 389‐fold), was...
In obesity, the combined effects of enhanced food consumption, oxidative stress and microinflammation could augment advanced glycation end products (AGEs) accumulation in plasma. We compared plasma concentrations AGEs soluble receptor for (sRAGE) relation to markers stress, renal function obese lean children/adolescents.In 18 apparently healthy children/adolescents (7 females/11 males; age: 5-18 years; body mass index, BMI: 27.3+/-3.3 kg/m2) controls (10 females/8 4-17 years, 22.4+/-2.1...
Application of electricity for pain treatment dates back to thousands years BC. The Ancient Egyptians and later the Greeks Romans recognized that electrical fishes are capable generating electric shocks relief pain. In 18th 19th centuries these natural producers were replaced by man-made devices. This happened in following phases. first was application static currents (called Franklinism), which produced a friction generator. Christian Kratzenstein apply it medically, followed shortly...
The aim of this study was to investigate the effects rooibos tea as a natural source wide scale antioxidants on prevention and treatment oxidative stress in streptozotocin-induced diabetic rats. Expected significant changes biochemical parameters characteristic for experimental state were found plasma tissues eight weeks after single dose streptozotocin application. Administration aqueous alkaline extracts (or N-acetyl-L-cysteine comparison) rats did not affect markers status (glucose,...
Introduction Infant formula-feeding is associated with reduced insulin sensitivity. In rodents and healthy humans, advanced glycation end product (AGE)-rich diets exert diabetogenic effects. comparison human breast-milk, infant formulas contain high amounts of AGEs. We assessed the role AGEs in infant-formula-consumption-associated resistance. Methods Total plasma levels Nε-(carboxymethyl)lysine (CML), AGEs-associated fluorescence (λex = 370 nm/λem 445 nm), soluble adhesion molecules,...
Oxidative stress markers are usually measured in plasma, a stable environment for biomarkers. Blood collection is invasive, but the use of alternative biofluids limited, due to high variability. In this study, we aimed establish reference values oxidative urine and saliva adult, healthy mice identify some sources Samples were obtained from 41 female 37 male CD-1 strain, aged 95-480 days, weighing 21-55 grams. Reference ranges TBARS (thiobarbituric acid reactive substances), AOPP (advanced...
Abstract Conditions predisposing to metabolic syndrome (MetS) are associated with increased oxidative stress and inflammation. We studied, in vegetarians ( n = 90) omnivores 46), the impact of dietary regimen on occurrence MetS risk factors (RFs: BMI, blood pressure, glucose metabolism lipid profile) relation status (advanced glycation end products (AGEs), advanced oxidation protein (AOPPs), malondialdehyde, ferric reducing ability plasma, vitamins A, E, C, β‐carotene superoxide dismutase...
Interaction of advanced glycation end products (AGEs) with their specific cell-surface receptor for AGEs (RAGE) induces production reactive oxygen species, pro-diabetic, pro-inflammatory, and pro-atherogenic responses. The metabolic syndrome (Metsy) imposes a high risk development cardiovascular disease unequivocally predisposes the non-diabetics to type 2 diabetes mellitus. aim study was investigate association between circulating soluble RAGE (sRAGE), Nε-(carboxymethyl)lysine (CML) or...