A5023272919- Stress Responses and Cortisol
- Hormonal and reproductive studies
- Hypothalamic control of reproductive hormones
- Neuroscience of respiration and sleep
- Circadian rhythm and melatonin
- Salivary Gland Disorders and Functions
- Neuroendocrine regulation and behavior
- Obstructive Sleep Apnea Research
- Sexual Differentiation and Disorders
- Cannabis and Cannabinoid Research
- Chronic Kidney Disease and Diabetes
- Biochemical effects in animals
- COVID-19 Clinical Research Studies
- Nutritional Studies and Diet
- Oral microbiology and periodontitis research
- Advanced Glycation End Products research
- Estrogen and related hormone effects
- COVID-19 and healthcare impacts
- Cancer Genomics and Diagnostics
- Cancer Research and Treatments
- Acute Kidney Injury Research
- Advanced biosensing and bioanalysis techniques
- Phytoestrogen effects and research
- Long-Term Effects of COVID-19
- Single-cell and spatial transcriptomics
Comenius University Bratislava
2015-2024
University Hospital Bratislava
2012-2024
Czech Academy of Sciences, Institute of Physiology
2004-2021
Slovak Academy of Sciences
2014-2016
Biomedical Research Center of the Slovak Academy of Sciences
2005-2016
Max Planck Institute for Molecular Biomedicine
2013
Biomed Research Institute
2009
Abstract Background Covid-19 is a disease with high morbidity and mortality among elderly residents of long-term care facilities (LTCF). During an outbreak SARS-CoV-2 infection in the LTCF effective screening tool essential to identify patients at risk for severe disease. We explored role interleukin 6 (IL-6) as predictor during one Slovakia. Methods conducted retrospective data analysis cases COVID-19, diagnosed Slovakia between April 11, 2020, May 5, 2020. Within 24 h after diagnosis...
Brain oxytocin regulates a variety of social and affiliative behaviors affects also learning memory. However, mechanisms its action at the level neuronal circuits are not fully understood. The present study tests hypothesis that molecular factors required for memory formation synaptic plasticity, including brain‐derived neurotrophic factor, neural growth nestin, microtubule‐associated protein 2 (MAP2), synapsin I, enhanced by central administration oxytocin. We investigated whether enhances...
Summary In the fight against recent COVID‐19 pandemics, testing is crucial. Nasopharyngeal swabs and real‐time RT‐PCR are used for detection of viral RNA. The collection saliva non‐invasive, pain‐free does not require trained personnel. An alternative to loop‐mediated isothermal amplification coupled with reverse transcription (RT‐LAMP) that easy perform, quick a thermal cycler. aim this study was test whether SARS‐CoV‐2 RNA can be detected directly in using RT‐LAMP. We have tested 16 primer...
Salivary TBARS are a potential marker of oxidative stress in the oral cavity. Previous studies have found increased levels salivary various diseases. The aim this study was to assess variability both genders.Saliva samples from thirty-eight healthy volunteers (18F & 20M) were collected every day during 30 period. measured spectrophotometrically using high-throughput 96-well plate method. Time series analysis performed standard statistical methods.Repeated measures ANOVA showed significant...
Introduction : Salivary TBARS are a potential marker of oxidative stress in the oral cavity. Previous studies have found increased levels salivary various diseases. The aim this study was to assess variability both genders. Subjects & Methods Saliva samples from thirty-eight healthy volunteers (18F 20M) were collected every day during 30 period. measured spectrophotometrically using high-throughput 96-well plate method. Time series analysis performed standard statistical methods. Results...
Background:Cronobacter spp. is an opportunistic pathogen causing rare but dangerous cases of meningitis, sepsis and urinary tract infection. Phage therapy overcomes antibiotic resistance represents alternative approach to standard antimicrobial treatment. There are no published studies on the use phages against Cronobacter in vivo. The aim our study was prove effects isolated Cronobacter-specific renal colonization a model infection mice.Material/Methods:Urinary induced by transurethral...
Several recent studies have shown that liver injury is associated with the release of DNA from hepatocytes. This stimulates innate immunity and induces sterile inflammation, exacerbating damage. Similar mechanisms been described for acute renal injury. Deoxyribonuclease degrades cell-free can potentially prevent some induced tissue study analyzed effects thioacetamide-induced hepatorenal on plasma in rats. Plasma both nuclear mitochondrial origin was higher thioacetamide-treated animals....
Background. Thiobarbituric reacting substances (TBARS) are markers of lipoperoxidation. The best‐known specific TBARS is malondialdehyde (MDA). Results from our previous studies have shown that can be measured in saliva and increased patients with gingivitis. Whether MDA the main altered parodontal status unknown. Aim. To observe relationship between TBARS, number epithelial cells saliva. Subjects & Methods. In Study I plasma samples 15 (8F, 7M) suffering inflammatory periodontal...
Infradian rhythms of sex hormones in women are important several physiological and pathophysiological processes. Detailed analyses these difficult due to problems with sampling. Salivary levels steroids widely used when repeated sampling is needed. However, a description variation during the menstrual cycle daily lacking. In our study salivary testosterone, estradiol progesterone were measured samples collected by 17 young healthy (21,2+/-0,7 years) one cycle. Sex steroid determined using...
Abstract Aims For decades, Slovakia has maintained a prominent place in mortality rates from cardiovascular diseases among European Union ( EU ‐27) countries. Determination of skin autofluorescence serves as an estimate tissue accumulation advanced glycation end products—substances accumulating tissues and body fluids that play pathophysiological role age‐related their complications, such diabetes. Methods In 1385 apparently healthy Slovakian subjects aged few days old to 77 years, was...
Decreased renal function due to chronic kidney disease (CKD) is associated with anxiety and cognitive decline. Although these mental disorders are often obvious in late stage patients, they might be unnoticeable or neglected early stages of the CKD development. Associations between dysfunction have been indicated by studies performed mainly patients undergoing dialysis, which itself represents a stress decreased quality life. However, experimental causal scarce. Our aim was investigate...
Sex and gender matter in all aspects of life. Humans exhibit sexual dimorphism anatomy, physiology, but also pathology. Many the differences are due to sex chromosomes and, thus, genetics, other endocrine factors such as hormones, some social origin. Over past decades, huge number scientific studies have revealed striking human brain with remarkable behavioral cognitive consequences. Prenatal postnatal testosterone influence structures functions, respectively. Cognitive include especially...