A5087331143- Salivary Gland Disorders and Functions
- Oral microbiology and periodontitis research
- Acute Kidney Injury Research
- Advanced Glycation End Products research
- Dialysis and Renal Disease Management
- Organ Donation and Transplantation
- Chronic Kidney Disease and Diabetes
- Biochemical effects in animals
- Hormonal and reproductive studies
- Renal Transplantation Outcomes and Treatments
- Urinary Tract Infections Management
- Stress Responses and Cortisol
- Vitamin C and Antioxidants Research
- Cancer Genomics and Diagnostics
- Diet, Metabolism, and Disease
- Pregnancy and preeclampsia studies
- Hypothalamic control of reproductive hormones
- Organ Transplantation Techniques and Outcomes
- Atrial Fibrillation Management and Outcomes
- Renal and related cancers
- Adipose Tissue and Metabolism
- Reproductive System and Pregnancy
- Oral Health Pathology and Treatment
- Neuroendocrine regulation and behavior
- Obstructive Sleep Apnea Research
Comenius University Bratislava
2015-2025
University Library in Bratislava
2020-2022
Washington University in St. Louis
2021
Institute of Normal and Pathological Physiology of the Slovak Academy of Sciences
2020
Slovak Academy of Sciences
2014-2016
University of South Bohemia in České Budějovice
2014-2016
Biomedical Research Center of the Slovak Academy of Sciences
2016
Salivary markers of oxidative stress and antioxidant status represent promising tool for the research oral diseases. One criteria is validation these biomarkers from perspective confounding modifying factors.To examine effect circadian rhythm, tooth-brushing ascorbic acid treatment on selected salivary carbonyl stress, status.Whole unstimulated saliva samples were collected 19 healthy participants three times during a day, before after tooth-brushing, administration vitamin C (250 mg)....
BACKGROUND: Salivary markers of oxidative stress and antioxidant status represent promising tool for the research oral diseases. One criteria is validation these biomarkers from perspective confounding modifying factors. AIM: To examine effect circadian rhythm, tooth-brushing ascorbic acid treatment on selected salivary carbonyl stress, status. SUBJECTS AND METHODS: Whole unstimulated saliva samples were collected 19 healthy participants three times during a day, before after tooth-brushing,...
Salivary oxidative stress markers represent a promising tool for monitoring of oral diseases. Saliva can often be contaminated by blood, especially in patients with periodontitis. The aim our study was to examine the impact blood contamination on measurement salivary markers. samples were collected from 10 healthy volunteers and artificially (final concentration 0.001–10%). Next, saliva 12 gingivitis control before after dental hygiene treatment. Markers measured all samples. Advanced...
Periodontitis is a chronic disease with complex etiology that includes bacterial colonization, excessive inflammation, and oxidative stress. The hormone melatonin has antioxidant properties might contribute to alleviating conditions by reducing aim of this study was analyze the effect exogenous on periodontitis in an animal model as well patients periodontitis.In rats ligature-induced periodontitis, administered drinking water for two weeks. In human study, treatment-resistant were asked...
Urinary tract infections (UTI) are common types of bacterial infection in children. UTI treatment is aimed to prevent complications including hypertension, proteinuria, and progression chronic kidney disease. Activated neutrophils release chromatin-based structures associated with antimicrobial proteins called neutrophil extracellular traps (NETs). We describe the role NET-associated markers children as well NETs formation a mouse model UTI.Markers DNA (ecDNA), myeloperoxidase (MPO)...
Abstract Chronic kidney disease (CKD) is associated with chronic low-grade inflammation, but the primary factors triggering this inflammation remain unclear. Extracellular or cell-free DNA (exDNA) originates from virtually all tissues, being released during cell death, and stimulates innate immune system. Our study was designed as an observational, cross-sectional cohort of children CKD (both before after transplantation) controls to analyze associations between exDNA, markers cardiovascular...
Background : Previous studies have shown that salivary thiobarbituric acid reactive substances are related to the periodontal status in adults. Such an analysis has not been done on children yet. The aim of our study was analyze markers oxidative stress relation and dental children. Methods 82 consecutive pediatric patients assessed. oral hygiene index (OHI), papillary bleeding (PBI) caries (CI) were assessed as clinical parameters. Markers antioxidant measured whole saliva samples. Results...
Cancer is a risk factor for venous thromboembolism (VTE) and plasma d-dimer (DD) tissue (TF) are established VTE associated markers. Circulating tumor cells (CTCs) with the of in metastatic breast cancer. This study aimed to correlate CTCs, blood coagulation urokinase plasminogen activator (uPA) system primary cancer (PBC) patients. prospective included 116 PBC patients treated by surgery. CTCs were detected quantitative RT-PCR assay expression epithelial (CK19) or epithelial-mesenchymal...
Kidney disease is a worldwide health and economic burden, with rising prevalence. The search for biomarkers earlier more effective screening monitoring needed. Oxidative stress has been linked to both, acute kidney injury (AKI) chronic (CKD). aim of our study was investigate whether the concentrations systemic markers oxidative antioxidant status are affected by AKI CKD, identify potential biomarkers. In adult male Wistar rats, induced bilateral nephrectomy, CKD 5/6 nephrectomy. Blood...
Oxidative stress markers are usually measured in plasma, a stable environment for biomarkers. Blood collection is invasive, but the use of alternative biofluids limited, due to high variability. In this study, we aimed establish reference values oxidative urine and saliva adult, healthy mice identify some sources Samples were obtained from 41 female 37 male CD-1 strain, aged 95-480 days, weighing 21-55 grams. Reference ranges TBARS (thiobarbituric acid reactive substances), AOPP (advanced...
Type 1 pili have long been considered the major virulence factor enabling colonization of urinary bladder by uropathogenic Escherichia coli (UPEC). The molecular pathogenesis pyelonephritis is less well characterized, due to previous limitations in preclinical modeling kidney infection. Here, we demonstrate a recently developed mouse model that beyond infection, type also are critical for establishment ascending pyelonephritis. Bacterial mutants lacking pilus adhesin (FimH) were unable...
Background:Cronobacter spp. is an opportunistic pathogen causing rare but dangerous cases of meningitis, sepsis and urinary tract infection. Phage therapy overcomes antibiotic resistance represents alternative approach to standard antimicrobial treatment. There are no published studies on the use phages against Cronobacter in vivo. The aim our study was prove effects isolated Cronobacter-specific renal colonization a model infection mice.Material/Methods:Urinary induced by transurethral...