A5050740286- Testicular diseases and treatments
- Cancer Cells and Metastasis
- Sarcoma Diagnosis and Treatment
- Neuroblastoma Research and Treatments
- Cancer Immunotherapy and Biomarkers
- Cancer Genomics and Diagnostics
- Gut microbiota and health
- Inflammatory Biomarkers in Disease Prognosis
- Cancer Diagnosis and Treatment
- Bladder and Urothelial Cancer Treatments
- Metastasis and carcinoma case studies
- Cancer Treatment and Pharmacology
- Epigenetics and DNA Methylation
- Glioma Diagnosis and Treatment
- Renal cell carcinoma treatment
- Ovarian cancer diagnosis and treatment
- Multiple Myeloma Research and Treatments
- Histone Deacetylase Inhibitors Research
- Urologic and reproductive health conditions
- Pancreatic and Hepatic Oncology Research
- Cancer-related cognitive impairment studies
- Cancer, Hypoxia, and Metabolism
- Multiple and Secondary Primary Cancers
- Neutropenia and Cancer Infections
- Probiotics and Fermented Foods
Comenius University Bratislava
2016-2025
National Institute of Cardiovascular Diseases
2012-2025
Biomedical Research Center of the Slovak Academy of Sciences
2019-2024
Cancer Research Institute of the Slovak Academy of Sciences
2013-2024
Cancer Institute (WIA)
2014-2024
Slovak Medical University
2005-2023
National Cancer Institute
2007-2022
National Institute of Oncology
2022
Slovak Academy of Sciences
2012-2021
Národný Onkologický Ústav
2016-2020
Abstract Introduction Circulating tumor cells (CTCs) represent an independent predictor of outcome in patients with metastatic breast cancer (MBC). We assessed the prognostic impact CTCs according to different first-line systemic treatments, and explored their potential predictive value MBC patients. Methods retrospectively evaluated 235 newly diagnosed patients, treated at University Texas MD Anderson Cancer Center. All had a baseline CTC assessment performed CellSearch ® . Progression-free...
Currently, there is extensive information about circulating tumor cells (CTC) and their prognostic value; however, little known other characteristics of these cells. In this prospective study, we assessed the gene transcripts epithelial-to-mesenchymal transition-inducing transcription factors (EMT-TF) cancer stem cell (CSC) features in patients with HER2(+) metastatic breast (MBC). Epithelial were enriched from peripheral blood mononuclear (PBMC) using antibody-coated anti-CD326 antibody...
Epithelial cancer cells are likely to undergo epithelial-mesenchymal transition (EMT) prior entering the peripheral circulation. By undergoing EMT, circulating tumor (CTCs) lose epithelial markers and may escape detection by conventional methods. Therefore, we conducted a pilot study investigate mRNA transcripts of EMT-inducing transcription factors (TFs) in from blood (PB) patients with primary breast (PBC). PB mononuclear were isolated 52 stages I-III PBC 30 healthy donors (HDs)...
Traditional factors currently used for prognostic stratification do not always adequately predict treatment response and disease evolution in advanced breast cancer patients. Therefore, the use of blood-based markers, such as circulating tumor cells (CTCs), represents a promising complementary strategy monitoring. In this retrospective study, we explored role CTC counts predictors patients with limited metastatic dissemination.A total 492 who had count assessed by CellSearch prior to...
Inflammatory breast cancer (IBC) is the most insidious form of locally advanced cancer; about a third patients have distant metastasis at initial staging. Emerging evidence suggests that host factors in tumor microenvironment may interact with underlying IBC cells to make them aggressive. It unknown whether immune associated play role this scenario transiently promote epithelial mesenchymal transition (EMT) these cells. We hypothesized soluble secreted by activated can induce an EMT and thus...
Circulating tumor cells (CTC) are an independent prognostic factor in metastatic breast cancer patients (MBC). However, CTC undetectable one third of patients. The aim this study was to assess the factors MBC without detectable CTC. This retrospective included 292 evaluated between January 2004 and December 2007. were enumerated before started a new line treatment using CellSearch™. Overall survival (OS) calculated from date measurement estimated by Kaplan-Meier product limit method. not...
Circulating tumor cells (CTCs) play a crucial role in dissemination and are prognostic primary metastatic breast cancer. Peripheral blood (PB) immune contribute to an unfavorable microenvironment for CTC survival. This study aimed correlate CTCs with the PB T-cell immunophenotypes functions of patients inflammatory cancer (IBC).This included 65 IBC treated at MD Anderson Cancer Center. was obtained from prior starting new line chemotherapy enumeration by CellSearch(®), T cell phenotype...
We evaluated systemic immune-inflammation index (SII) and its association with patient outcome in germ-cell tumours (GCTs).Two independent cohorts of patients were analysed; the discovery set (n=171) from a single institution validation (n=181) previously included study evaluating PD-L1 GCTs. The SII was calculated using platelet (P), neutrophil (N) lymphocyte (L) counts before chemotherapy correlated survival regression analyses Kaplan-Meier method.In cohort, associated poor risk clinical...
// Michal Chovanec 1, 2, 7, * , Zuzana Cierna 3, Viera Miskovska 4 Katarina Machalekova 5 Daniela Svetlovska 6 Kalavska 8 Rejlekova 7 Stanislav Spanik Karol Kajo Pavel Babal 9 Jozef Mardiak Mego 1 2nd Department of Oncology, Comenius University, Faculty Medicine & National Cancer Institute, Bratislava, Slovak Republic 2 Translational Research Unit, 3 Pathology, Medicine, 1st St. Elisabeth Medical University Clinical Trials, Academy Sciences, Hospital with Policlinics Skalica, a.s., M-CH and...
Cytokines are involved in cancer invasion and metastasis. Circulating tumor cells (CTCs) play key role dissemination an independent survival predictor breast patients. The aim of this study was to assess correlation between CTCs plasma cytokines primary (PBC) This included 147 chemotherapy naïve PBC Peripheral blood mononuclear (PBMC) were depleted hematopoetic using RossetteSep™ negative selection kit. RNA extracted from CD45-depleted PBMC interrogated for expression EMT (Twist1, Snail1,...
Abstract Germ cell tumours predominantly of the testis ((T)GCTs) are remarkably chemotherapy sensitive. However, a small proportion patients fail to be cured with cisplatin‐based combination chemotherapy. miR‐371a‐3p is new liquid biopsy biomarker for (T)GCTs. The aim this study was evaluate clinical utility plasma level in starting systemic Patients were included before first cycle (N = 180) and second 101) line chemotherapy, treated between July 2010 May 2017. Plasma levels measured...
We retrospectively evaluated the correlation between a baseline measurement of circulating tumor cells (CTCs) and inflammation-based scores in patients with metastatic breast cancer (MBC).The optimal value as neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte (PLR), monocyte-lymphocyte (MLR) systemic immune-inflammation index (SII) to predict survival was determined compared CTC <5 or ⩾5 per 7.5 ml blood.In overall population 516 women MBC, CTCs correlated peripheral blood monocytes (p =...