A5013185839- Quantum Chromodynamics and Particle Interactions
- Nuclear physics research studies
- Organic and Molecular Conductors Research
- Dental Trauma and Treatments
- Pharmacy and Medical Practices
- Quantum, superfluid, helium dynamics
- High-Energy Particle Collisions Research
- dental development and anomalies
- Magnetism in coordination complexes
- Acoustic Wave Resonator Technologies
- Biochemical and Molecular Research
- Dental Implant Techniques and Outcomes
- Antibiotics Pharmacokinetics and Efficacy
- Cold Atom Physics and Bose-Einstein Condensates
- Cancer therapeutics and mechanisms
- Gut microbiota and health
- Polymer Surface Interaction Studies
- Marine Biology and Environmental Chemistry
- Pharmacological Effects of Natural Compounds
- Glycosylation and Glycoproteins Research
- HIV/AIDS drug development and treatment
- Food Quality and Safety Studies
- Characterization and Applications of Magnetic Nanoparticles
- Oral and Craniofacial Lesions
- Tea Polyphenols and Effects
Shinonoi General Hospital
2022-2024
Tokyo Dental College
2020-2024
Nitobe Memorial Nakano General Hospital
2019
Tsurumi University
2019
Junshin Gakuen University
2015-2018
Sapporo Kosei General Hospital
2017
Yamato Municipal Hospital
2016
Jichi Medical University
2016
Uji Hospital
2015
Iwate Prefectural Kamaishi Hospital
2007-2014
The dehydroepiandrosterone (DHEA) concentration decreases with age. There is evidence that DHEA has a protective effect against age-related disorders, including cardiovascular disease. Accordingly, we examined the of supplementation (25 mg/d) on endothelial function, insulin sensitivity, and fibrinolytic activity in 24 men hypercholesterolemia (mean age, 54 ± 1 yr). All subjects were enrolled randomized, double-blind study. Flow-mediated dilation brachial artery after transient occlusion,...
Barnacles are a unique sessile crustacean that attach irreversibly and firmly to foreign underwater surfaces. Its biological adhesive is peculiar extracellular multi-protein complex. Here we characterize one of the two major proteins, 52 kDa protein found in barnacle cement Cloning cDNA revealed has no homolog nonredundant database. The primary structure consists four long sequence repeats. process dissolving at joint animal by various treatments was monitored order obtain insight into...
Barnacles are unique marine sessile crustaceans and permanently attach to various foreign surfaces during most of their lifespan. The protein complex secreted from body used calcareous shell almost all in water has long fascinated us because we have limited technology with which materials water. Unraveling the mechanism underwater attachment by barnacles is thus important for interface science, understanding biology physiology barnacles, development prevent fouling. Previous studies...
Barnacle attachment to various foreign materials in water is guided by an extracellular multiprotein complex. A 19 kDa cement protein was purified from the Megabalanus rosa cement, and its cDNA cloned sequenced. The gene expressed only basal portion of animal, where histologically identified gland located. sequence showed no homology other known proteins databases, indicating that it a novel protein. Agreement between molecular mass determined MS weight estimated indicated bears...
The aim of this study was to investigate the effects rooibos tea as a natural source wide scale antioxidants on prevention and treatment oxidative stress in streptozotocin-induced diabetic rats. Expected significant changes biochemical parameters characteristic for experimental state were found plasma tissues eight weeks after single dose streptozotocin application. Administration aqueous alkaline extracts (or N-acetyl-L-cysteine comparison) rats did not affect markers status (glucose,...
The barnacle relies for its attachment to underwater foreign substrata on the formation of a multiprotein complex called cement. 20 kDa cement protein is component Megabalanus rosa cement, although specific function in has not, until now, been known. recombinant form expressed bacteria was purified soluble under physiological conditions, and confirmed retain almost same structure as that native protein. Both from adhesive layer were characterized. This revealed abundant Cys residues, which...
An underwater bioadhesive generally comprises a multiprotein complex that provides molecular basis for self-assembly. We report here new class of self-assembling peptide inspired by 20 kDa barnacle cement protein. Studies on the chemically synthesized 24-residue have revealed (1) it underwent irreversible self-assembly upon addition salt, (2) was started at salt concentration close to seawater with noncovalent intermolecular interactions, (3) self-assembled material resembled macroscopic...
We investigated the promoting effect of medium chain fatty acid salts such as sodium caprylate, caprate (Na C10) and laurate on rat nasal absorption insulin. Further, we studied possible mechanism by in terms hemolytic activity, osmotic pressure, chelating inhibition leucine aminopeptidase activity. Na C10 exhibited strongest insulin among these salts. The was very rapid reaching maximum immunoreactive level within 5 min its optimum concentration about 1%. amount absorbed after a...
Interaction of nalidixic acid with aluminum ion was revealed by spectrophotometric study. Stoichiometry the acid-aluminum complex estimated to be 3 1 method continuous variations. The interaction further supported an increase in solubility drug increasing concentration ion, a decrease (carbon tetrachloride/acetate buffer, pH3.3) partition coefficient aqueous layer, and permeation rate through cellulose membrane presence donor compartment. nalidixate anion magnesium calcium ions also shown...
In order to verify whether vitamin E improves the cognitive impairment induced through aging, aged rats fed a E-supplemented diet had their learning and memory functions assessed in comparison with normal using Morris water maze test. Although showed very poor ability concerning place of platform apparatus, learned marked speed only 5 trials. After old animals maximum ability, they were kept atmosphere for 48 h without trial followed by an assessment function same apparatus. The...
Summary The aim of this study was to investigate the usage tooth autotransplantation in dental clinics which offer treatment and evaluate its practicality. Participating dentists were requested provide information on transplantations they had undertaken from 1 January 1990 31 December 2010. A total 614 teeth 552 patients (37 dentists) ranging age 17 79 (mean age: 44·1) examined. Cumulative survival rate mean time calculated using Kaplan–Meier method, log rank test used for analysis factors....
The authors tested the hypothesis that low‐salt diet education by nutritionists would lower blood pressure ( BP ) levels in treated hypertensive patients. amount of urinary salt excretion and clinic, home, ambulatory values at baseline 3 months were measured 95 patients with hypertension. After randomization to a nutritional group (E group, n=51) or control (C n=44), C received conventional salt‐restriction E intensive aimed restriction 6 g/d nutritionists. From end study, 24‐hour sodium was...
Insulin resistance leads to the onset of medical conditions such as type 2 diabetes, and its development is associated with alteration in gut microbiota. Although it has been demonstrated that supplementation prebiotics modulates microbiota, limited evidence available for effects on insulin resistance, especially humans. We investigated prebiotic effect 1-kestose fasting concentration obesity-prone humans rats. In preliminary study using rats, hyperinsulinemia induced by high-fat diet was...
In two-dimensional (2D) multiband metals, the interference through chemical potential oscillation (CPO), which is described in text, shown to cause conventionally unexpected frequency components de Haas-van Alphen (dHvA) oscillation; as an example, numerical result for a two-band case shown. Then, we discuss relevance of CPO appearance prohibited dHvA 2D magnetic breakdown (MB) systems, where “the oscillation” means one not permitted standard semiclassical theory incorporates MB. From these,...
Intestinal microbiotas of human subjects and effect antibiotic treatment on them have been reported with cultivation independent methods. However, Japanese fecal not studied enough. We constructed a clone library method to obtain results within 3 d. In this study, intestinal 29 healthy adults, whose samples were collected twice at 5 month intervals from each subject, analyzed our method, using those data as benchmark was evaluated. The fifty-eight assessed based percentages genus level, the...
Studies reveals that plasma leptin levels (LEP) in females are higher than those males, and LEP hypertensive subjects BMI-matched normotensive subjects. To investigate the relationships among LEP, blood pressure (BP) insulin sensitivity, we studied these 133 Japanese males 263 females. were positively correlated with BP, body mass index, fat (FM) homeostasis model assessment (HOMA). Regression analysis which age FM adjusted showed associated BP HOMA. Even adjustment by age, HOMA, still...
Nasal absorption of insulin in rats was enhanced by addition sodium glycyrrhetinate (GA Na), dipotassium glycyrrhizinate (GZ K2), and carbenoxolone (glycyrrhetinic acid hydrogen succinate) disodium salt (GAHS Na2). The latter agent the most effective. On 1% GAHS Na2, plasma immunoreactive levels showed a maximum level 0.75 mU/ml at 15 min glucose were decreased to about 25 mg/dl after nasal administration 10 U/kg insulin. In comparison rates intravenous (i.v.) routes rats, absorptions...
Water-in-oil-in-water (W/O/W) type double emulsions were prepared by two-step emulsification procedures. The structures of W/O/W and the release characteristics cytarabine 5-fluorouracil (5-FU) from studied. ruptured within 24h when sorbitan monooleate (SO-10) or sesquioleate (SO-15) was used as a lipophilic emulsifier. On other hand, in hydrogenated castor oil (HCO-10) peanut still intact after 24h. Therefore, drugs studied HCO-10 oil. very prolonged. enhanced with increase volume inner...
The purpose of our study was to examine the effects job stress factors on oxidative DNA injuries among female workers. levels urinary 8-hydroxydeoxyguanosine (8-OH-dG) were measured along with a survey work conditions and environments. result showed that workers in shift excreted increased 8-OH-dG comparison those who engaged part time (P<0.01). Moreover, nurses marked higher depressive scores significantly than scored lower states. revealed positive correlation between 35-45 age group...
The aim of this study was to investigate the risk factors affecting long-term prognosis autotransplantation third molars with complete root formation in males at dental clinics. Participating dentists were requested provide information on transplantations they had undertaken from 1 January 1990 31 December 2010. Data a total 708 teeth 637 patients collected. After data screening and elimination, participants consisted 183 171 ranging 20 72 years age (mean age, 44·8 years). cumulative...