A5013530647- Genomics and Phylogenetic Studies
- Gut microbiota and health
- PI3K/AKT/mTOR signaling in cancer
- Microbial Community Ecology and Physiology
- Cancer-related gene regulation
- Microbial Natural Products and Biosynthesis
- Liver Disease Diagnosis and Treatment
- Cancer-related Molecular Pathways
- Tryptophan and brain disorders
- Diet and metabolism studies
- RNA modifications and cancer
- RNA Research and Splicing
- Alzheimer's disease research and treatments
- Autophagy in Disease and Therapy
- HER2/EGFR in Cancer Research
- Epigenetics and DNA Methylation
- Diet, Metabolism, and Disease
- Glycosylation and Glycoproteins Research
- Endoplasmic Reticulum Stress and Disease
- Mitochondrial Function and Pathology
- Peptidase Inhibition and Analysis
- Cancer-related molecular mechanisms research
- Galectins and Cancer Biology
- Protease and Inhibitor Mechanisms
- Chronic Myeloid Leukemia Treatments
Nara Women's University
2016-2025
Keio University
2022-2025
University of Palermo
2023
Vall d'Hebron Hospital Universitari
2023
Nanzan University
2022
University of Belgrade
2021
University of the Ryukyus
1996-2020
Satou Hospital
2018
Osaka University
1991-2015
Symbiosis International University
2014
Several pharmacological agents acting on monoamine neurotransmission are used for the management of mental illnesses. Regulation PI3K/AKT and GSK3 pathways may constitute an important signaling center in subcellular integration synaptic neurotransmission. The also modulate neuronal cell proliferation, migration, plasticity. There evidences to suggest that inflammation neuron contributes pathology depression. Inflammatory activation loss glial elements, which consistent with pathological...
Nonalcoholic fatty liver disease (NAFLD) is the most common form of pathologies and associated with obesity metabolic syndrome, which represents a range diseases an increased risk type 2 diabetes. Molecular mechanisms underlying how to make transition from simple nonalcoholic steatohepatitis (NASH) are not well understood. However, accumulating evidence indicates that deregulation phosphatidylinositol 3-kinase (PI3K)/AKT pathway in hepatocytes molecular event dysfunctions including obesity,...
Malignant tumors are heterogeneous diseases characterized by uncontrolled cell proliferation, invasion, and/or metastasis. In particular, cancer stem cells within these might be responsible for the invasiveness and property of recurrence malignancies. It has been reported that matrix metalloproteases (MMPs) tissue inhibitors metalloproteinases (TIMPs) could contribute to development tumor invasiveness. Remarkably, specific MMPs can drive malignant phenotype counting acquisition feature, in...
The mutant c-erbB-2 protein with Glu instead of Val-659 exhibited transforming activity in NIH 3T3 cells. This showed enhanced tyrosine kinase vitro and autophosphorylation at Tyr-1248 located proximal to the carboxyl terminus. Enhanced phosphorylation several cellular proteins was detected cells expressing Glu-659 protein. Introduction an additional mutation ATP-binding site (Lys-753 Met) this resulted abolition its ability. These data indicate that potential is closely correlated elevated...
Ten pale-pink- and pale-yellow-pigmented, Gram-negative, non-motile, rod-shaped, chemoheterotrophic bacteria designated strains YM20-087T, YM21-151, MN1-741T, YM27-120T, YM26-010T, YM24-184, YM20-122, A4T-83T, A5J-41-2T A5J-40 were isolated from various marine environments subjected to a polyphasic taxonomic investigation. Phylogenetic analyses based on 16S rRNA gene sequences indicated that these isolates belonged the phylum 'Verrucomicrobia' (subdivision 1) represented three independent...