A5025361514- Functional Brain Connectivity Studies
- Advanced MRI Techniques and Applications
- Transcranial Magnetic Stimulation Studies
- Advanced Neuroimaging Techniques and Applications
- EEG and Brain-Computer Interfaces
- Parkinson's Disease Mechanisms and Treatments
- Neural and Behavioral Psychology Studies
- Metabolism and Genetic Disorders
- Mental Health Research Topics
- Epilepsy research and treatment
- Lipoproteins and Cardiovascular Health
- Neural dynamics and brain function
- Dialysis and Renal Disease Management
- Education, Psychology, and Social Research
- Erythrocyte Function and Pathophysiology
- Adipose Tissue and Metabolism
- Vitamin D Research Studies
- Neurological disorders and treatments
- Adipokines, Inflammation, and Metabolic Diseases
- Diet and metabolism studies
- Hormonal Regulation and Hypertension
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Vitamin C and Antioxidants Research
- Liver Disease Diagnosis and Treatment
- Neurological and metabolic disorders
Masaryk University
2014-2024
Central European Institute of Technology – Masaryk University
2015-2024
Central European Institute of Technology
2015-2024
St. Anne's University Hospital Brno
2021-2024
University Hospital Brno
2023
Slovak Medical University
2007-2021
Sokolovská Uhelná (Czechia)
2021
Slovak University of Technology in Bratislava
2020
Slovenské Elektrárne (Slovakia)
2018
Brno University of Technology
2011-2012
Transcranial direct current stimulation combined with cognitive training (tDCS-cog) represents a promising approach to combat decline among healthy older adults and patients mild impairment (MCI). In this 5-day-long double-blinded randomized trial, we investigated the impact of intensified tDCS-cog protocol involving two trains per day on working memory (WM) enhancement in 35 amnestic multidomain MCI patients. Specifically, focused improve WM tasks relying top-down attentional control...
Diabetes increases bone fracture risk. Trigonelline, an alkaloid with potential antidiabetic activity, is present in considerable amounts coffee. The aim of the study was to investigate effects trigonelline on experimental diabetes-induced disorders rat skeletal system. Effects (50 mg/kg p.o. daily for four weeks) were investigated three-month-old female Wistar rats, which, two weeks before start administration, received streptozotocin (60 i.p.) or after nicotinamide (230 i.p.). Serum...
Interaction of advanced glycation end products (AGEs) with their specific cell-surface receptor for AGEs (RAGE) induces production reactive oxygen species, pro-diabetic, pro-inflammatory, and pro-atherogenic responses. The metabolic syndrome (Metsy) imposes a high risk development cardiovascular disease unequivocally predisposes the non-diabetics to type 2 diabetes mellitus. aim study was investigate association between circulating soluble RAGE (sRAGE), Nε-(carboxymethyl)lysine (CML) or...
We examined effects of theta burst stimulation (TBS) applied over two distinct cortical areas (the right inferior frontal gyrus and the left superior parietal lobule) on Stroop task performance in 20 young healthy subjects. Neural underpinnings behavioral effect were tested using fMRI. A single session intermittent TBS lobule induced certain cognitive speed enhancement significantly increased resting-state connectivity dorsal attention network. This is an exploratory study that prompts...
Many cognitive functions, including working memory, are processed within large-scale brain networks. We targeted the right frontoparietal network (FPN) with one session of transcranial direct current stimulation (tDCS) in an attempt to modulate speed a visual memory task (WMT) 27 young healthy subjects using double-blind crossover design. further explored neural underpinnings induced changes by performing resting-state fMRI prior and immediately after each main focus on interaction between...
AimTo estimate the impact of high fat diet and estrogen deficiency on oxidative antioxidative status in liver ovariectomized rats, as well ameliorating effect physical activity or consumption functional food containing bioactive compounds with properties damage rat liver.MethodsThe study was conducted from November 2012 to April 2013. Liver determined by lipid peroxidation levels expressed terms thiobarbituric acid reactive substances (TBARS), while catalase (CAT), glutathione peroxidase...
Abstract Many methods applied to data acquired by various imaging modalities have been evaluated for their benefit in localizing lesions magnetic resonance (MR) negative epilepsy patients. No approach has proven be a stand‐alone method with sufficiently high sensitivity and specificity. The presented study addresses the potential of automated fusion results individual presurgical evaluation. We collected electrophysiological, MR, nuclear from 137 patients pharmacoresistant...
Enhancing cognitive functions through noninvasive brain stimulation is of enormous public interest, particularly for the aging population in whom processes such as working memory are known to decline. In a randomized double-blind crossover study, we investigated acute behavioral and neural aftereffects bifrontal frontoparietal transcranial direct current (tDCS) combined with visual (VWM) training on 25 highly educated older adults. Resting-state functional connectivity (rs-FC) analysis was...
Abstract The objective was to determine the optimal combination of multimodal imaging methods (IMs) for localizing epileptogenic zone (EZ) in patients with MR-negative drug-resistant epilepsy. Data from 25 focal epilepsy (age 30 ± 10 years, 16M/9F) who underwent surgical resection EZ and 110 healthy controls 31 9 years; 56M/54F) were used evaluate IMs based on 3T MRI, FDG-PET, HD-EEG, SPECT. Patients successful outcomes and/or positive histological findings evaluated. From 38 calculated per...
Hypovitaminosis D associates with obesity, insulin resistance, hypertension, and dyslipoproteinemia. We asked whether the presence of multiple cardiometabolic risk factors, which particular combination, exerts additive negative effects on 25(OH)D3 levels; levels associate markers inflammation oxidative stress.In non-diabetic medication-free adults central obesity (waist-to-height ratio > 0.5); elevated blood pressure (systolic BP≥130 mm Hg and/or diastolic BP ≥85 Hg); increased atherogenic...
Verbal communication relies heavily upon mutual understanding, or common ground. Inferring the intentional states of our interaction partners is crucial in achieving this, and social neuroscience has begun elucidating intra- inter-personal neural processes supporting such inferences. Typically, however, neuroscientific paradigms lack reciprocal to-and-fro characteristic communication, offering little insight into way these operate online during real-world interaction. In present study, we...
Summary Data of 52 patients, 29 women and 23 men aged 32–68 years (mean age 47 years) with essential hypertension, participating in three open therapeutic trials either enalapril, lisinopril, or perindopril were evaluated to assess the effects angiotensin-converting enzyme (ACE) inhibition on glucose lipid metabolism. The 75-g oral tolerance test (oGTT) was performed, plasma insulin levels, as well total cholesterol, high-density lipoprotein (HDL)-cholesterol, triglycerides levels determined...
Diabetes may lead to the development of osteoporosis. Coffee drinking, apart from its health benefits, is taken into consideration as an osteoporosis risk factor. Data human and animal studies on coffee caffeine bone effects are inconsistent. The aim study was investigate at a moderate dose skeletal system rats in two models experimental diabetes induced by streptozotocin. Effects administered orally (20 mg/kg aily for four weeks) were investigated three-month-old female Wistar rats, which,...
Drug-resistant epilepsy is a diagnostic and therapeutic challenge, mainly in patients with negative MRI findings. State-of-the-art imaging methods complement standard protocols new information help epileptologists to increase the reliability of their decisions. In this study, we investigate whether arterial spin labeling (ASL) perfusion can localize epileptogenic zone (EZ). To that end, developed an image processing method detect EZ as area hypoperfusion relative contralateral unaffected...
<i>Background:</i> Guidelines recommend regular measurements of the delivered hemodialysis dose Kt/V. Nowadays, automatic non-invasive online are available as alternatives to conventional method with blood sampling, laboratory analysis, and calculation. <i>Methods:</i>In a prospective clinical trial, three different methods determining dialysis were simultaneously applied: Kt/V<sub>Dau</sub> (conventional Daugirdas’ formula), Kt/V<sub>OCM</sub>...
BACKGROUND: Vitamin D plays a role in protecting against chronic degenerative diseases.Slovak adults present one of the highest cardiovascular mortality rates among 27 EU countries.OBJECTIVES: We asked whether 25(OH)D 3 status apparently healthy medication-free Slovaks deteriorates upon ageing, and presence cardiometabolic risk factors.METHODS: studied impact blood pressure, overweight/obesity, smoking, physical activity on levels determined using RIA method 578 (5-81 years old)...