A5091640818- Bone Metabolism and Diseases
- Diet and metabolism studies
- Bone health and osteoporosis research
- Vitamin D Research Studies
- Adipose Tissue and Metabolism
- Natural Antidiabetic Agents Studies
- Diabetes Treatment and Management
- Pancreatic function and diabetes
- Curcumin's Biomedical Applications
- Metabolism, Diabetes, and Cancer
- Anesthesia and Pain Management
- Estrogen and related hormone effects
- Hormonal and reproductive studies
- Liver Disease Diagnosis and Treatment
- Chemical Reactions and Isotopes
- Plant-based Medicinal Research
- Phytochemical Studies and Bioactivities
- Phytochemistry and biological activities of Ficus species
- TGF-β signaling in diseases
- Berberine and alkaloids research
- Coffee research and impacts
- Metabolism and Genetic Disorders
- Neuroendocrine regulation and behavior
- Pharmacological Effects and Toxicity Studies
- Neuroscience and Neuropharmacology Research
Medical University of Silesia
2014-2025
Górnośląskie Centrum Medyczne
2011
Diabetes increases bone fracture risk. Trigonelline, an alkaloid with potential antidiabetic activity, is present in considerable amounts coffee. The aim of the study was to investigate effects trigonelline on experimental diabetes-induced disorders rat skeletal system. Effects (50 mg/kg p.o. daily for four weeks) were investigated three-month-old female Wistar rats, which, two weeks before start administration, received streptozotocin (60 i.p.) or after nicotinamide (230 i.p.). Serum...
It is believed that apple fruits contain components with health-promoting effects, including some antidiabetic activity. One of the most known compounds phloridzin, a glucoside phloretin. Phloridzin and phloretin were reported to exert favorable skeletal effects in estrogen-deficient rats mice. The aim study was investigate phloridzin on musculoskeletal system type 2 diabetes induced by high-fat diet (HFD) streptozotocin (STZ). experiments performed mature female Wistar rats, divided into...
Scope Trigonelline (1‐methylpyridinium‐3‐carboxylate), an alkaloid present in coffee and fenugreek seed, has been reported to exhibit phytoestrogenic activity. The aim of the study was investigate effects trigonelline on bone mechanical properties rats with normal estrogen level deficiency (developing osteoporosis). Methods results experiments were performed 3‐month‐old nonovariectomized ovariectomized (estrogen‐deficient) Wistar rats, divided into control receiving (50 mg/kg p.o. daily) for...
The results of epidemiological, clinical, and in vivo vitro experimental studies on the effect opioid analgesics bone are inconsistent. aim present study was to investigate morphine (an agonist receptors), buprenorphine (a partial μ receptor κ antagonist), naloxone antagonist receptors) skeletal system female rats vivo. experiments were carried out 3-month-old Wistar rats, divided into two groups: nonovariectomized (intact; NOVX) ovariectomized (OVX) rats. bilateral ovariectomy performed 7...
There is a great interest in substances of plant origin, which may exert health-promoting activities diabetes and its complications. Previous studies suggested that diosgenin favorably affect both glucose metabolism osteoporosis. The aim the study was to investigate effects on skeletal disorders induced by experimental type 1 (T1D) rats. experiments were performed 3-month-old female rats, divided into three groups: I – healthy control II streptozotocin-induced diabetic III rats receiving...
Diabetes may lead to the development of osteoporosis. Coffee drinking, apart from its health benefits, is taken into consideration as an osteoporosis risk factor. Data human and animal studies on coffee caffeine bone effects are inconsistent. The aim study was investigate at a moderate dose skeletal system rats in two models experimental diabetes induced by streptozotocin. Effects administered orally (20 mg/kg aily for four weeks) were investigated three-month-old female Wistar rats, which,...
Sodium-glucose cotransporter 2 (SGLT2) inhibitors are a new class of antidiabetic drugs, acting by inhibiting the reabsorption glucose in kidneys. They turned out to improve cardiovascular and renal outcomes not only patients with type diabetes but also nondiabetic patients. At present, they more widely used without diabetes. Since there were concerns that SGLT2 may increase fracture risk diabetes, aim study was examine effect dapagliflozin canagliflozin on musculoskeletal system...
Although postmenopausal osteoporosis often occurs concurrently with diabetes, little is known about interactions between estrogen deficiency and hyperglycemia in the skeletal system. In present study, effects of on development biochemical, microstructural, mechanical changes induced by streptozotocin-induced diabetes mellitus (DM) rat system were investigated. The experiments carried out nonovariectomized (NOVX) ovariectomized (OVX) control diabetic mature female Wistar rats. Serum levels...
The gut microbiota plays an important role in maintaining homeostasis, including that of the skeletal system. Antibiotics may affect system directly or indirectly by influencing microbiota. Probiotic bacteria have been reported to favorably bones conditions estrogen deficiency. aim this study was investigate effects azithromycin (AZM) administered alone with probiotic (Lactobacillus rhamnosus; LR) on estrogen-deficient rats. experiments were carried out mature rats divided into five groups:...
Background: Histamine H 1 receptor antagonists are widely used in the treatment of allergic diseases. receptors expressed on bone cells and histamine takes part regulation metabolism. Loratadine is often prescribed to children. Purpose: The aim present study was investigate effects loratadine skeletal system young rats. Material methods: (0.5, 5, 50 mg/kg p.o. daily) administered for 4 weeks male Wistar rats, 6-week-old at start experiment. Bone mass, mass mineral, calcium, phosphorus...
Multidirectional health-promoting activities of some plant-derived substances make them candidates for drugs used in diabetes and its complications such as osteoporosis. Berberine is a compound which both antidiabetic antiosteoporotic effects have been documented. The aim the study was to investigate berberine on skeletal disorders induced by experimental type 1 rats. experiments were performed 3-month-old female rats, divided into three groups: I - healthy control II diabetic III rats...
Searchable abstracts of presentations at key conferences on calcified tissues ISSN 2052-1219 (online)
Searchable abstracts of presentations at key conferences on calcified tissues ISSN 2052-1219 (online)
Searchable abstracts of presentations at key conferences on calcified tissues ISSN 2052-1219 (online)