A5034456496- Muscle Physiology and Disorders
- Developmental Biology and Gene Regulation
- Venomous Animal Envenomation and Studies
- Congenital heart defects research
- Rabies epidemiology and control
- Adipose Tissue and Metabolism
- Muscle metabolism and nutrition
- Tissue Engineering and Regenerative Medicine
- Marine Invertebrate Physiology and Ecology
- TGF-β signaling in diseases
- Wnt/β-catenin signaling in development and cancer
- High Altitude and Hypoxia
- Neurogenetic and Muscular Disorders Research
- Metabolism and Genetic Disorders
- Cardiomyopathy and Myosin Studies
- Diet and metabolism studies
- Genetic Neurodegenerative Diseases
- Hedgehog Signaling Pathway Studies
- Mesenchymal stem cell research
- Animal Genetics and Reproduction
- Neonatal Respiratory Health Research
- Genetics and Physical Performance
- RNA Research and Splicing
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Head and Neck Cancer Studies
University of Reading
2016-2025
MRC Weatherall Institute of Molecular Medicine
2023-2024
University of Oxford
2001-2024
Nokia (United States)
2024
John Radcliffe Hospital
2024
North Memorial Health Care
2018-2023
International Spine, Pain & Performance
2022
Centers for Disease Control and Prevention
2022
Centers for Disease Control and Prevention
2022
University of Freiburg
2015-2021
Abstract Molecular studies of squamous cell carcinoma the head and neck (HNSCC) have demonstrated multiple genetic abnormalities such as activation various oncogenes (Ras, Myc, epidermal growth factor receptor, cyclin D1), tumor suppressor gene inactivation (TP53 p16), loss heterozygosity at numerous chromosomal locations. Despite these observations, accurate reliable biomarkers that predict patients highest risk for local recurrence yet to be defined. In an effort identify expression...
The lack of myostatin promotes growth skeletal muscle, and blockade its activity has been proposed as a treatment for various muscle-wasting disorders. Here, we have examined two independent mouse lines that harbor mutations in the gene, constitutive null (Mstn(-/-)) compact (Berlin High Line, BEH(c/c)). We report that, despite larger muscle mass relative to age-matched wild types, there was no increase maximum tetanic force generation, but when expressed function size (specific force),...
The mechanisms underpinning the regenerative capabilities of mesenchymal stem cells (MSC) were originally thought to reside in their ability recognise damaged tissue and differentiate into specific cell types that would replace defective cells. However, recent work has shown molecules produced by MSCs (secretome), particularly those packaged extracellular vesicles (EVs), rather than themselves are responsible for repair.Here we have a secretome from adipose-derived (ADSC) is free exogenous...
Satellite cells represent the stem cell population of adult skeletal muscle. The molecular mechanisms that control proliferation satellite are not well understood. In this study, we show in response to injury, myofibres activate Wnt ligand transcription and a reporter line is sensitive canonical Wnt-signalling pathway. Activated on isolated cultured robust expression activated-beta-catenin (Act-beta-Cat), key downstream transcriptional coactivator signalling. We provide evidence family...
Myostatin, a member of the TGF-beta family, has been identified as powerful inhibitor muscle growth. Absence or blockade myostatin induces massive skeletal hypertrophy that is widely attributed to proliferation population fiber-associated satellite cells have principle source new tissue during growth and regeneration. Postnatal proposed basis for therapeutic strategies combat loss in genetic acquired myopathies. But this approach, according accepted mechanism, would raise threat premature...
Lateral Patella dislocations are common injuries seen in the active and young adult populations. Our study focus was to evaluate medial patellofemoral ligament (MPFL) injury patterns associated knee pathology using Magnetic Resonance Imaging studies.MRI studies taken at one imaging site between January, 2007 2008 with final diagnosis of patella dislocation were screened for this study. Of 324 cases that found, 195 patients lateral patellar traumatic enough cause bone bruises on femoral...
Orthophosphate (P(i)) is an essential but limiting macronutrient for plant growth. Extensive soil P reserves exist in the form of organic (P(o)), which unavailable root uptake until hydrolysed by secretory acid phosphatases (APases). The predominant purple APase (PAP) isozymes secreted roots P(i)-deficient (-P(i)) Arabidopsis thaliana were recently identified as AtPAP12 (At2g27190) and AtPAP26 (At5g34850). present study demonstrated that exogenous P(o) compounds such glycerol-3-phosphate or...
In vertebrates, body musculature originates from somites, whereas head muscles originate the cranial mesoderm. Neck are located in transition between these regions. We show that chick occipital lateral plate mesoderm has myogenic capacity and gives rise to large neck thorax. present molecular genetic evidence not only have a unique origin, but additionally display distinct temporal development, forming later than any other muscle group described date. further report muscles, found of animal,...
While constant basal levels of macroautophagy/autophagy are a prerequisite to preserve long-lived podocytes at the filtration barrier, MTOR regulates same time podocyte size and compensatory hypertrophy. Since is known generally suppress autophagy, apparently independent regulation these two key pathways glomerular maintenance remained puzzling. We now report that long-term genetic manipulation activity does in fact not influence high autophagy either vitro or vivo. Instead we present data...
Administration of extracellular vesicles derived from amniotic fluid stem cells regenerates underdeveloped fetal lungs in rodents.
Antimicrobial peptides have been developed based on plant-derived molecular scaffolds for the treatment of infectious diseases. Chenopodin is an abundant seed storage protein in quinoa, Andean plant with high nutritional and therapeutic properties. Here, we used computer- physicochemical-based strategies designed four derived from primary structure Chenopodin. Two reproduce natural fragments 14 amino acids Chenopodin, named Chen1 Chen2, two engineered same length were sequence. The...
Abstract Embryonic muscle growth requires a fine balance between proliferation and differentiation. In this study we have investigated how is achieved during chick development. Removal of ectoderm from trunk somites results in the down-regulation Pax-3 expression cell division myogenic precursors halted. This initially leads to an up-regulation MyoD burst terminal differentiation but further arrested. Locally applied bone morphogenetic protein-4 (BMP-4) mimics effect stimulates which...
ABSTRACT Tbx-2, Tbx-3, Tbx-4 and Tbx-5 chick genes have been isolated and, like the mouse homologues, are expressed in limb regions. Tbx-2 Tbx-3 anterior posterior domains wings legs, as well throughout flank. Of particular interest, however, Tbx-5, which is wing flank but not leg, Tbx-4, very strongly leg wing. Grafts of tissue to give rise toe-like or wing-like digits respectively. Expression stable when grafted wing, expression leg. Induction either extra legs from by applying FGF-2...
Protein tyrosine kinases (PTKs) have been implicated in the development of many common human tumours including melanoma. Previously we isolated PTK gene sequences expressed normal melanocytes. Here examined expression 9 these genes cell lines derived from defined stages melanoma progression, by Northern blotting and some cases immunoblotting. We also tested cells 2 animal models particular as well uncultured biopsies metastatic The receptor kinase family members found melanocytes, PTK7/CCK-4...