A5100374464- Infant Nutrition and Health
- Neonatal Respiratory Health Research
- Gut microbiota and health
- Congenital Anomalies and Fetal Surgery
- Clinical Nutrition and Gastroenterology
- Organ Transplantation Techniques and Outcomes
- Tissue Engineering and Regenerative Medicine
- Cardiac Ischemia and Reperfusion
- Anesthesia and Neurotoxicity Research
- Food composition and properties
- Extracellular vesicles in disease
- Digestive system and related health
- MicroRNA in disease regulation
- Pediatric Hepatobiliary Diseases and Treatments
- Circular RNAs in diseases
- Immune Response and Inflammation
- Pancreatic function and diabetes
- Liver Disease and Transplantation
- Probiotics and Fermented Foods
- Polysaccharides Composition and Applications
- Congenital gastrointestinal and neural anomalies
- Clostridium difficile and Clostridium perfringens research
- Cardiac, Anesthesia and Surgical Outcomes
- Diabetes and associated disorders
- Respiratory Support and Mechanisms
SickKids Foundation
2016-2025
Hospital for Sick Children
2016-2025
University of Toronto
2016-2025
Air Force Medical University
2012-2025
Xijing Hospital
2012-2025
GlaxoSmithKline (United States)
2023-2025
Jinan Maternity And Care Hospital
2025
Southwest Medical University
2025
Union Hospital
2021-2025
Huazhong University of Science and Technology
2011-2025
Journal Article Nutrition Intervention Trials in Linxian, China: Supplementation With Specific Vitamin/Mineral Combinations, Cancer Incidence, and Disease-Specific Mortality the General Population Get access William J. Blot, Blot National InstituteBethesda, Md. Correspondence to : Ph.D., Biostatistics Branch, Division of Etiology, Institute, 6130 Executive Blvd., Rockville, MD 20852 Search for other works by this author on: Oxford Academic PubMed Google Scholar Jun-Yao Li, Li Chinese Academy...
Rationale: Lung fibroblasts are key mediators of fibrosis resulting in accumulation excessive interstitial collagen and extracellular matrix, but their origins not well defined.Objectives: We aimed to elucidate the contribution lung epithelium–derived via epithelial–mesenchymal transition (EMT) intratracheal bleomycin model.Methods: Primary type II alveolar epithelial cells were cultured from Immortomice exposed transforming growth factor-β1 epidermal factor. Cell fate reporter mice that...
Necrotizing enterocolitis (NEC) is characterized by intestinal injury and impaired mucin synthesis. We recently showed that breast milk exosomes from rodents promote cell viability, epithelial proliferation, stem activity, but whether they also affect mucus production unknown. Therefore, the aim of this study was to investigate effects bovine milk-derived on goblet expression in experimental NEC delineate potential underlying mechanisms action. Exosomes were isolated ultracentrifugation...
Abstract Background Despite emerging evidence on the therapeutic potential of mesenchymal stem cells (MSCs) for liver fibrosis, underlying mechanisms remain unclear. At present, MSC-derived exosomes (MSC-EXOs) are widely accepted as crucial messengers intercellular communication. This study aimed to explore effects MSC-EXOs fibrosis and identify action MSC-EXOs. Methods Carbon tetrachloride was used induce a model, which intravenously administered with MSCs or assess treatment efficacy. The...
Nicotiana tabacum and benthamiana are widely used models in plant biology research. However, genomic studies of these species have lagged. Here we report the chromosome-level reference genome assemblies for N. with an estimated 99.5% 99.8% completeness, respectively. Sensitive transcription start termination site sequencing methods were developed accurate gene annotation tabacum. Comparative analyses revealed evidence parental origins chromosome structural changes, leading to hybrid...
<ns4:p>Necrotizing enterocolitis is a devastating intestinal disease affecting preterm infants. In spite of ongoing research and advancement in neonatal care, mortality remains high, especially infants with advanced disease. The mechanism development, the progression injury, management remain areas controversy. this review, we examine our current understanding disease, its epidemiology, risk factors associated development pathophysiology. We also describe new emerging highlighting potential...
Scope Necrotizing enterocolitis (NEC) is a leading cause of morbidity and death in preterm infants, occurring more often formula‐fed than breastfed infants. Studies both rats humans show that human milk oligosaccharides (HMOs) lower the incidence NEC, but mechanism underlying such protection currently unclear. Methods Results By extracting HMOs from pooled breastmilk, impact on intestinal mucin levels murine model NEC are investigated. To confirm results, findings validated by exposing...
Abstract Gut microbiota dysbiosis has a significant role in the pathogenesis of metabolic diseases, including obesity. Nuciferine (NUC) is main bioactive component lotus leaf that been used as food China since ancient times. Here, we examined whether anti-obesity effects NUC are related to modulations gut microbiota. Using an obese rat model fed HFD for 8 weeks, show supplementation rats prevents weight gain, reduces fat accumulation, and ameliorates lipid disorders. Furthermore, 16S rRNA...
Abstract Necrotizing enterocolitis (NEC) is a devastating neonatal disease characterized by acute intestinal injury. Intestinal stem cell (ISC) renewal required for gut regeneration in response to The Wnt/β-catenin pathway essential and ISC maintenance. We found that expression, Wnt activity were all decreased both mice with experimental NEC infants active NEC. Moreover, organoids derived from NEC-injured intestine of humans failed maintain proliferation presented more differentiation....
Half of women over the age 50 will experience a fracture related osteoporosis in their lifetime. The common treatment is estrogen replacement therapy, which can cause many side effects. Puerarin as phytoestrogen has been proven to improve postmenopausal osteoporosis. However, mechanisms anti-osteoporosis remain unclear due its low bioavailability. aim this study investigate whether effects puerarin are modulations gut microbiota and focus on mechanism / bone axis. We established...
Administration of extracellular vesicles derived from amniotic fluid stem cells regenerates underdeveloped fetal lungs in rodents.
Despite tremendous progress in the development of mature heart-on-a-chip models, human cell-based models myocardial inflammation are lacking. Here, we bioengineered a vascularized with circulating immune cells to model severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-induced myocarditis. We observed hallmarks disease (COVID-19)-induced inflammation, as presence augmented secretion proinflammatory cytokines, triggered progressive impairment contractile function, and altered...
Abstract We investigated the impact of inflammatory signaling in airway epithelial cells on host defense against Pseudomonas aeruginosa, a major cause nosocomial pneumonia. In mice, instillation P. aeruginosa resulted NF-κB activation lungs that was primarily localized to bronchial epithelium at 4 h, but present variety cell types by 24 h. modulated activity intratracheal delivery adenoviral vectors expressing RelA (AdRelA) or dominant inhibitor before infection. Bacterial clearance enhanced...
Major depressive disorder (MDD) is a common mood disorder. Gut microbiota may be involved in the pathogenesis of depression via microbe-gut-brain axis. Liver vulnerable to exposure bacterial products translocated from gut portal vein and In this study, germ-free mice underwent fecal transplantation MDD patients healthy controls. Behavioral tests verified model. Metabolomics using gas chromatography-mass spectrometry, nuclear magnetic resonance, liquid spectrometry determined influence...
Prebiotics are non-digestible food ingredients that enhance the growth of certain microbes within gut microbiota. Prebiotic consumption generates immune-modulatory effects traditionally thought to reflect microbial interactions gut. However, recent evidence suggests they may also impart direct microbe-independent on host, though mechanisms which currently unclear.Kinome arrays were used profile host intestinal signaling responses prebiotic exposures in absence microbes. Identified pathways...
Abstract Necrotizing enterocolitis (NEC) is a devastating disease of premature infants with high mortality rate, indicating the need for precision treatment. NEC characterized by intestinal inflammation and ischemia, as well derangements in microcirculation. Remote ischemic conditioning (RIC) has emerged promising tool protecting distant organs against ischemia-induced damage. However, effectiveness RIC unknown. To address this gap, we aimed to determine efficacy mechanism action...