A5043511757- SARS-CoV-2 and COVID-19 Research
- Gut microbiota and health
- COVID-19 Clinical Research Studies
- Circular RNAs in diseases
- MicroRNA in disease regulation
- Viral gastroenteritis research and epidemiology
- Diet and metabolism studies
- COVID-19 epidemiological studies
- COVID-19 Impact on Reproduction
- Tryptophan and brain disorders
- Acute Lymphoblastic Leukemia research
- Plant Ecology and Soil Science
- Viral Infections and Immunology Research
- Respiratory viral infections research
- Clostridium difficile and Clostridium perfringens research
- Long-Term Effects of COVID-19
- Environmental and Agricultural Sciences
- Bacterial biofilms and quorum sensing
- RNA Research and Splicing
- Chronic Myeloid Leukemia Treatments
- Mosquito-borne diseases and control
- Viral Infections and Vectors
- interferon and immune responses
- Eosinophilic Esophagitis
- Immune responses and vaccinations
Xinqiao Hospital
2019-2025
Army Medical University
2018-2025
Sichuan Agricultural University
2024-2025
Liaoning Academy of Agricultural Sciences
2025
University of Hong Kong
2018-2024
Chinese University of Hong Kong
2023-2024
Wenzhou Medical University
2017-2024
Hunan Institute of Mental Health
2022-2024
Hunan University
2022-2024
Shandong University
2024
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was reported from China in January, 2020. SARS-CoV-2 is efficiently transmitted person to and, months, has caused more than 82 000 laboratory-confirmed cases of disease 2019 (COVID-19) and 2800 deaths 46 countries. The total number surpassed that the 2003 severe (SARS-CoV). Although both COVID-19 (SARS) manifest as pneumonia, associated with apparently efficient transmission, fewer diarrhoea, increased mental confusion, a lower...
Abstract Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an emerging that has resulted in more than 000 laboratory-confirmed cases including over 145 deaths. Although SARS-CoV-2 and SARS-CoV share a number of common clinical manifestations, appears to be highly efficient person-to-person transmission frequently causes asymptomatic or presymptomatic infections. However, the underlying mechanisms confer these viral characteristics high transmissibility infection...
Recent studies show that exosomes are involved in intercellular communication and abundant circular RNAs (circRNAs) present within exosomes. However, whether these exosomal circRNAs contribute to tumor invasion metastasis remains unclear, as do their associated mechanisms. Quantitative reverse transcription-polymerase chain reaction (qRT-PCR) was used measure the expression levels of circ-IARS 85 pancreatic ductal adenocarcinoma (PDAC) tissues, plasma exosomes, Hs 766 T, T-L2 human...
Coronavirus tropism is predominantly determined by the interaction between coronavirus spikes and host receptors. In this regard, coronaviruses have evolved a complicated receptor-recognition system through their spike proteins. Spikes from highly related can recognize distinct receptors, whereas of distant employ same cell-surface molecule for entry. Moreover, broad range molecules in addition to receptors thereby augment attachment or The receptor Middle East respiratory syndrome...
Clinical manifestations of coronavirus disease 2019 (COVID-19) vary from asymptomatic virus shedding, nonspecific pharyngitis, to pneumonia with silent hypoxia and respiratory failure. Dendritic cells macrophages are sentinel for innate adaptive immunity that affect the pathogenesis severe acute syndrome (SARS) Middle East (MERS). The interplay between SARS-CoV-2 these cell types remains unknown. We investigated infection host responses monocyte-derived dendritic (moDCs) (MDMs) infected by...
Abstract National-based prospective surveillance of all-age patients with acute diarrhea was conducted in China between 2009‒2018. Here we report the etiological, epidemiological, and clinical features 152,792 eligible enrolled this analysis. Rotavirus A norovirus are two leading viral pathogens detected patients, followed by adenovirus astrovirus. Diarrheagenic Escherichia coli nontyphoidal Salmonella bacterial pathogens, Shigella Vibrio parahaemolyticus . Patients aged <5 years had...
Abstract Understanding the factors that contribute to efficient SARS-CoV-2 infection of human cells may provide insights on transmissibility and pathogenesis, reveal targets intervention. Here, we analyze host viral determinants essential for in both lung epithelial ex vivo tissues. We identify heparan sulfate as an important attachment factor infection. Next, show sialic acids present ACE2 prevent spike/ACE2-interaction. While SARS-CoV is substantially limited by acid-mediated restriction...
Abstract Background Modification of the gut microbiota has been reported to reduce incidence type 1 diabetes mellitus (T1D). We hypothesized that shifts might also have an effect on cognitive functions in T1D. Herein we used a non-absorbable antibiotic vancomycin modify streptozotocin (STZ)-induced T1D mice and studied impact microbial changes performances its potential gut-brain neural mechanism. Results found exposure disrupted microbiome, altered host metabolic phenotypes, facilitated...
Nicotiana tabacum and benthamiana are widely used models in plant biology research. However, genomic studies of these species have lagged. Here we report the chromosome-level reference genome assemblies for N. with an estimated 99.5% 99.8% completeness, respectively. Sensitive transcription start termination site sequencing methods were developed accurate gene annotation tabacum. Comparative analyses revealed evidence parental origins chromosome structural changes, leading to hybrid...
Infection by highly pathogenic coronaviruses results in substantial apoptosis. However, the physiological relevance of apoptosis pathogenesis coronavirus infections is unknown. Here, with a combination vitro, ex vivo, and vivo models, we demonstrated that protein kinase R-like endoplasmic reticulum (PERK) signaling mediated proapoptotic signals Middle East respiratory syndrome (MERS-CoV) infection, which converged intrinsic pathway. Inhibiting PERK or both alleviated MERS vivo. Severe acute...
The outbreak of coronavirus disease 2019 (COVID-19), which is caused by severe acute respiratory syndrome 2 (SARS-CoV-2), has posed a serious threat to global public health. mechanism pathogenesis and the host immune response SARS-CoV-2 infection are largely unknown. In present study, we applied quantitative proteomic technology identify quantify ubiquitination changes that occur in both virus Vero E6 cells during infection. By applying label-free, liquid chromatography with tandem mass...
Cyclic dimeric guanosine monophosphate (c-di-GMP) serves as a bacterial second messenger that modulates various processes including biofilm formation, motility, and host-microbe symbiosis. Numerous studies have conducted comprehensive analysis of c-di-GMP. However, the mechanisms by which certain environmental signals such iron control intracellular c-di-GMP levels are unclear. Here, we show regulates in Pseudomonas aeruginosa modulating interaction between an iron-sensing protein, IsmP,...
Childhood obesity is linked to maternal smoking during pregnancy. Gut microbiota may partially mediate this association and could be potential targets for intervention; however, its role understudied. We included 1,592 infants from the Canadian Healthy Infants Longitudinal Development Cohort. Data on environmental exposure lifestyle factors were collected prenatally throughout first three years. Weight outcomes measured at one years of age. Stool samples 3 12 months analyzed by sequencing V4...
Abstract Cells that sustain double-strand breaks (DSB) can develop genomic instability, which contributes to carcinogenesis, and agents cause DSBs are considered potential carcinogens. We looked for evidence of acid-induced DNA damage, including DSBs, in benign Barrett's epithelial (BAR-T) cell lines vitro patients with esophagus vivo. In BAR-T cells, we also explored the mechanisms underlying damage. exposed cells acid presence a fluorescent probe reactive oxygen species (ROS) or absence...
The objective of this study was to evaluate the effects number freeze-thaw (F-T) cycles on moisture migration, protein degradation, microstructure and quality in Litopenaeus vannamei. samples with different F-T were determined by low-field nuclear magnetic resonance (LF-NMR), imaging (MRI) scanning electron microscopy (SEM), combined sodium dodecyl sulphate polyacrylamide gel electrophoresis (SDS-PAGE), texture properties analysis (TPA), color difference, polyphenol oxidase (PPO) activity,...
Circular RNAs (circRNAs) are an integral component of the host competitive endogenous RNA (ceRNA) network. These noncoding characterized by their unique splicing reactions to form covalently closed loop structures and play important regulatory roles in cells. Recent studies showed that circRNA expressions were perturbed viral infections circRNAs might serve as potential antiviral targets. We investigated ceRNA network changes biological relevance human lung adenocarcinoma epithelial (Calu-3)...
Highlights•Genetic inactivation of Ezh2 or Eed cooperates with NRASQ61K in leukemogenesis•Inactivation enhances a stem-cell-related transcriptional program•Inactivation results increased STAT3 activation via Y705 phosphorylationSummaryEarly T cell precursor acute lymphoblastic leukemia (ETP-ALL) is an aggressive subtype ALL distinguished by stem-cell-associated and myeloid programs. Inactivating alterations Polycomb repressive complex 2 components are frequent human ETP-ALL, but their...
This manuscript has been withdrawn as it was submitted without the full consent of all authors. Therefore, authors do not wish this work to be cited reference for project. If you have any questions, please contact corresponding author.
Besides prominent respiratory involvement, gastrointestinal manifestations are commonly reported in Coronavirus Disease 2019 (COVID-19) patients. We compared infection of ex vivo human intestinal tissues by SARS-CoV-2 and SARS-CoV with respect to their replication kinetics immune activation profile.Human were obtained from patients while undergoing surgical operations at Queen Mary Hospital, Hong Kong. Upon removal, the immediately processed infected or SARS-CoV. Replication determined...
Abstract Background Previous studies of primarily Western populations have reported contrasting associations dairy consumption with certain cancers, including a positive association prostate cancer and inverse colorectal premenopausal breast cancers. However, there are limited data from China where rates levels differ importantly those in populations. Methods The prospective Kadoorie Biobank study recruited ~0.5 million adults ten diverse (five urban, five rural) areas across during...
Abstract Background Diabetic cardiomyopathy (DCM) is one of leading causes diabetes-associated mortality. The gut microbiota-derived branched-chain amino acids (BCAA) have been reported to play a central role in the onset and progression DCM, but potential mechanisms remain elusive. Results We found type 1 diabetes (T1D) mice had higher circulating BCAA levels due reduced degradation ability microbiota. Excess decreased hepatic FGF21 production by inhibiting PPARα signaling pathway thereby...
ObjectivesRespiratory and intestinal tract are two primary target organs of SARS-CoV-2 infection. However, detailed characterization the host-virus interplay in infected human lung epithelial cells is lacking.MethodsWe utilized immunofluorescence assays, flow cytometry, RT-qPCR to delineate virological features innate immune response host against infection prototype cell lines representing (Calu3) (Caco2) epithelium when compared with SARS-CoV.ResultsLung were significantly more susceptible...