Yigang Tong
A5045599780- Bacteriophages and microbial interactions
- Genomics and Phylogenetic Studies
- Microbial infections and disease research
- Viral Infections and Vectors
- SARS-CoV-2 and COVID-19 Research
- Antibiotic Resistance in Bacteria
- Mosquito-borne diseases and control
- Viral gastroenteritis research and epidemiology
- Animal Virus Infections Studies
- Influenza Virus Research Studies
- Plant Virus Research Studies
- RNA and protein synthesis mechanisms
- Respiratory viral infections research
- Virus-based gene therapy research
- Viral Infections and Outbreaks Research
- Microbial Community Ecology and Physiology
- Monoclonal and Polyclonal Antibodies Research
- COVID-19 Clinical Research Studies
- Animal Disease Management and Epidemiology
- Infections and bacterial resistance
- CRISPR and Genetic Engineering
- Advanced biosensing and bioanalysis techniques
- Aquaculture disease management and microbiota
- Hepatitis B Virus Studies
- SARS-CoV-2 detection and testing
Beijing University of Chemical Technology
2018-2025
Zhejiang University
2024
Hubei University of Arts and Science
2024
Xiangyang Central Hospital
2024
Fudan University
2023-2024
Institute of Microbiology
2014-2023
Jiamusi University
2023
Academy of Military Medical Sciences
2010-2022
Beijing Technology and Business University
2022
University of British Columbia
2004-2021
The ongoing outbreak of viral pneumonia in China and across the world is associated with a new coronavirus, SARS-CoV-21. This has been tentatively seafood market Wuhan, China, where sale wild animals may be source zoonotic infection2. Although bats are probable reservoir hosts for SARS-CoV-2, identity any intermediate host that have facilitated transfer to humans unknown. Here we report identification SARS-CoV-2-related coronaviruses Malayan pangolins (Manis javanica) seized anti-smuggling...
Cross-species transmission of viruses from wildlife animal reservoirs poses a marked threat to human and health
Elevated levels of β-site APP cleaving enzyme 1 (BACE1) were found in the brain some sporadic Alzheimer's disease (AD) patients; however, underlying mechanism is unknown. BACE1 cleaves β-amyloid precursor protein (APP) to generate amyloid β (Aβ), a central component neuritic plaques AD brains. Nuclear factor-kappa B (NF-κB) signalling plays an important role gene regulation and implicated inflammation, oxidative stress apoptosis. In this report we that both NF-κB p65 significantly increased...
Abstract This article summarises the activities of Bacterial Viruses Subcommittee International Committee on Taxonomy for period March 2021−March 2022. We provide an overview new taxa proposed in 2021, approved by Executive Committee, and ratified vote Significant changes to taxonomy bacterial viruses were introduced: paraphyletic morphological families Podoviridae , Siphoviridae Myoviridae as well order Caudovirales abolished, a binomial system nomenclature species was established. In...
Abstract The ongoing outbreak of viral pneumonia in China and beyond is associated with a novel coronavirus, provisionally termed 2019-nCoV. This has been tentatively seafood market Wuhan, China, where the sale wild animals may be source zoonotic infection. Although bats are likely reservoir hosts for 2019-nCoV, identity any intermediate host facilitating transfer to humans unknown. Here, we report identification 2019-nCoV related coronaviruses pangolins ( Manis javanica ) seized...
Chikungunya virus (CHIKV) is an arthropod-borne of the family Togaviridae that transmitted to humans by Aedes spp. mosquitoes. Its genome comprises a 12 kb single-strand positive-sense RNA. In present study, we report patterns synonymous codon usage in 141 CHIKV genomes calculating several indices and applying multivariate statistical methods. Relative (RSCU) analysis showed preferred codons were G/C A-ended. A comparative RSCU between its hosts are mixture coincidence antagonism. Similarity...
Abstract In contrast to the many reports of successful real-world cases personalized bacteriophage therapy (BT), randomized controlled trials non-personalized products have not produced expected results. Here we present outcomes a retrospective observational analysis first 100 consecutive BT difficult-to-treat infections facilitated by Belgian consortium in 35 hospitals, 29 cities and 12 countries during period from 1 January 2008 30 April 2022. We assessed how often positive clinical...
Abstract Cepharanthine is a secondary metabolite isolated from Stephania . It has been reported that it anti-conronaviruses activities including severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Here, we assemble three genomes ( S. japonica , yunnanensis and cepharantha ), propose the cepharanthine biosynthetic pathway, assess antiviral potential of compounds involved in pathway. Among genomes, near telomere-to-telomere assembly with one remaining gap, have chromosome-level...
Early and precise detection identification of various pathogens are essential for epidemiological monitoring, disease management, reducing the prevalence clinical infectious diseases. Traditional pathogen techniques, which include mass spectrometry, biochemical tests, molecular testing, culture-based methods, limited in application time-consuming. Next generation sequencing (NGS) has emerged as an technology identifying pathogens. NGS is a cutting-edge method with high throughput that can...
We developed a dynamic forecasting model for Zika virus (ZIKV), based on real-time online search data from Google Trends (GTs). It was designed to provide disease (ZVD) surveillance and detection Health Departments, predictive numbers of infection cases, which would allow them sufficient time implement interventions. In this study, we found strong correlation between Zika-related GTs the cumulative reported cases (confirmed, suspected total cases; p<0.001). Then, used in ZIKV epidemics 12...
A novel Ebola virus (EBOV) first identified in March 2014 has infected more than 25,000 people West Africa, resulting 10,000 deaths. Preliminary analyses of genome sequences 81 EBOV collected from to June Guinea and Sierra Leone suggest that the originated an independent transmission event its natural reservoir followed by sustained human-to-human infections. It been reported variation might have effect on efficacy sequence-based detection candidate therapeutics. However, only limited viral...
The codon usage patterns of viruses reflect the evolutionary changes that allow them to optimize their survival and adapt fitness external environment and, most importantly, hosts. Here we report genotype-specific Zika virus (ZIKV) strains from current previous outbreaks. Several common traits were noted in ZIKV coding sequences, indicating independent origins a ancestor. overall influence natural selection was more profound than mutation pressure, acting on specific set viral genes...
During 2014-2015, an outbreak of Ebola virus disease (EVD) swept across parts West Africa. No approved antiviral drugs are available for treatment currently. A retrospective clinical case series was performed EVD patients in Sierra Leone-China Friendship Hospital. Patients with confirmed were sequentially enrolled and treated either World Health Organization (WHO)-recommended supportive therapy (control group) from 10 to 30 October, or WHO-recommended plus favipiravir (T-705) 1 November...
Animal models are critical to understand disease and develop countermeasures for the ongoing epidemics of Zika virus (ZIKV). Here we report a non-human primate model using 2016 contemporary clinical isolate ZIKV. Upon subcutaneous inoculation, rhesus macaques developed fever viremia, with robust excretion ZIKV RNA in urine, saliva, lacrimal fluid. Necropsy two infected animals revealed that systematic infections involving central nervous system visceral organs were established at acute...
The presence of hepatitis B virus (HBV) covalently closed circular DNA (cccDNA) and the permanent integration HBV into host genome confers risk viral reactivation hepatocellular carcinoma. Nucleoside/nucleotide analogues alone have little or no capacity to eliminate replicative templates consisting cccDNA integrated DNA. Recently, CRISPR/Cas9 technology has been widely applied as a promising genome-editing tool, HBV-specific CRISPR-Cas9 systems were shown effectively mediate disruption....
The Marburg virus (MARV) has a negative-sense single-stranded RNA genome, belongs to the family Filoviridae, and is responsible for several outbreaks of highly fatal hemorrhagic fever. Codon usage patterns viruses reflect series evolutionary changes that enable shape their survival rates fitness toward external environment and, most importantly, hosts. To understand evolution MARV at codon level, we report comprehensive analysis synonymous in genomes. Multiple approaches statistical methods...